Fndc5/irisin deficiency leads to dysbiosis of gut microbiota contributing to the depressive-like behaviors in mice

Liu, Xing; Hu, Qinxue; Xu, Tianhao; Yuan, Qionglan; Hu, Qin; Hu, Na; Sun, Weichao; Bai, Yiping; Liu, Li; Feng, Jianguo; Yi, Qian

doi:10.1016/j.brainres.2023.148537

Cited by 3 publications

(4 citation statements)

References 48 publications

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“…Another study showed increased depressive-and anxietylike behaviors in control and CUMS Fndc5/irisin-knockout mice when compared with their wild-type controls. Furthermore, Fndc5/irisin-knockout mice also showed altered diversity and richness of their gut microbiota, with a decrease in Firmicutes and an increase in Bacteroidetes, as well as a reduction in the relative abundance of Lactobacillus and Bifidobacterium [250]. These findings establish a relationship between irisin produced by muscle during physical exercise, the gut microbiota and mood regulation.…”

Section: Physical Exercise and Gut Microbiotamentioning

confidence: 65%

Major Depressive Disorder and Gut Microbiota: Role of Physical Exercise

Souza,

de Araujo Borba,

Castro de Jesus

et al. 2023

IJMS

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Major depressive disorder (MDD) has a high prevalence and is a major contributor to the global burden of disease. This psychiatric disorder results from a complex interaction between environmental and genetic factors. In recent years, the role of the gut microbiota in brain health has received particular attention, and compelling evidence has shown that patients suffering from depression have gut dysbiosis. Several studies have reported that gut dysbiosis-induced inflammation may cause and/or contribute to the development of depression through dysregulation of the gut–brain axis. Indeed, as a consequence of gut dysbiosis, neuroinflammatory alterations caused by microglial activation together with impairments in neuroplasticity may contribute to the development of depressive symptoms. The modulation of the gut microbiota has been recognized as a potential therapeutic strategy for the management of MMD. In this regard, physical exercise has been shown to positively change microbiota composition and diversity, and this can underlie, at least in part, its antidepressant effects. Given this, the present review will explore the relationship between physical exercise, gut microbiota and depression, with an emphasis on the potential of physical exercise as a non-invasive strategy for modulating the gut microbiota and, through this, regulating the gut–brain axis and alleviating MDD-related symptoms.

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Section: Physical Exercise and Gut Microbiotamentioning

confidence: 65%

Major Depressive Disorder and Gut Microbiota: Role of Physical Exercise

Souza,

de Araujo Borba,

Castro de Jesus

et al. 2023

IJMS

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“…Interestingly, these effects in colitis mice were accompanied by alterations in the biodiversity of the intestinal microbiota, changing the intestinal flora composition between the irisin-treated and control groups to be similar [53]. A study conducted on FNDC5 knockout mice further emphasized the significant role of irisin in preserving a healthy gut microbiome profile [54]. The knockout of the FNDC5 gene leads to a poorer diversity of gut microbiota and changes in microbiota-related metabolites [54].…”

Section: Irisin and The Gut Microbiomementioning

confidence: 99%

“…A study conducted on FNDC5 knockout mice further emphasized the significant role of irisin in preserving a healthy gut microbiome profile [54]. The knockout of the FNDC5 gene leads to a poorer diversity of gut microbiota and changes in microbiota-related metabolites [54]. Moreover, irisin has been shown to ameliorate lipopolysaccharide-induced inflammation in macrophages by MAPK/ERK and PI3K/AKT signaling pathways linked to the pathogenesis of UC and UC-associated colon cancer [55].…”

Section: Irisin and The Gut Microbiomementioning

confidence: 99%

The Role of the Myokine Irisin in the Protection and Carcinogenesis of the Gastrointestinal Tract

Pinkas,

Brzozowski

2024

Antioxidants

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Recently discovered irisin, a member of the myokines family, is a potential mediator of exercise-induced energy metabolism and a factor promoting browning of the white adipose tissue. Recent evidence indicates that this myokine, released from contracting muscles, can mediate the beneficial effects of exercise on health. Irisin may be a potential therapeutic agent against obesity and has been shown to play an important role in the protection of various cells, tissues, and organs due to its anti-inflammatory, antioxidative, and anti-cancer properties. Our aim was to review the recent experimental and clinical studies on irisin and its expression, release into the bloodstream, tissue targets, and potential contribution to the protective effects of exercise in the gastrointestinal tract. Particular emphasis was placed on inflammatory bowel disease, intestinal ischemia/reperfusion injury, periodontitis, and other digestive tract disorders, including carcinogenesis. Overall, irisin holds significant potential as a novel target molecule, offering a safe and therapeutic approach to treating various gastrointestinal diseases.

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“…The endocrine properties of skeletal muscles determine the release of myokines, cytokines, and proteins, exerting systemic effects on various body systems, including the digestive system and the gut microbiota [ 5 ]. For instance, irisin was recently identified as a myokine mostly produced and secreted into the circulation by adipose and skeletal muscle tissue [ 6 ]; the knockout of fibronectin type III domain-containing 5 (Fndc5)/irisin in mice caused altered diversity and richness of gut microbiota [ 7 ]. In return, gut bacteria influence skeletal muscle homeostasis through a multitude of signaling pathways, establishing a bidirectional gut–muscle axis.…”

Section: The Bidirectional Gut–muscle Axismentioning

confidence: 99%

Exploring the Gut Microbiota–Muscle Axis in Duchenne Muscular Dystrophy

Mostosi,

Molinaro,

Saccone

et al. 2024

IJMS

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The gut microbiota plays a pivotal role in maintaining the dynamic balance of intestinal epithelial and immune cells, crucial for overall organ homeostasis. Dysfunctions in these intricate relationships can lead to inflammation and contribute to the pathogenesis of various diseases. Recent findings uncovered the existence of a gut–muscle axis, revealing how alterations in the gut microbiota can disrupt regulatory mechanisms in muscular and adipose tissues, triggering immune-mediated inflammation. In the context of Duchenne muscular dystrophy (DMD), alterations in intestinal permeability stand as a potential origin of molecules that could trigger muscle degeneration via various pathways. Metabolites produced by gut bacteria, or fragments of bacteria themselves, may have the ability to migrate from the gut into the bloodstream and ultimately infiltrate distant muscle tissues, exacerbating localized pathologies. These insights highlight alternative pathological pathways in DMD beyond the musculoskeletal system, paving the way for nutraceutical supplementation as a potential adjuvant therapy. Understanding the complex interplay between the gut microbiota, immune system, and muscular health offers new perspectives for therapeutic interventions beyond conventional approaches to efficiently counteract the multifaceted nature of DMD.

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Fndc5/irisin deficiency leads to dysbiosis of gut microbiota contributing to the depressive-like behaviors in mice

Cited by 3 publications

References 48 publications

Major Depressive Disorder and Gut Microbiota: Role of Physical Exercise

Major Depressive Disorder and Gut Microbiota: Role of Physical Exercise

The Role of the Myokine Irisin in the Protection and Carcinogenesis of the Gastrointestinal Tract

Exploring the Gut Microbiota–Muscle Axis in Duchenne Muscular Dystrophy

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