FNDC5/Irisin: A New Protagonist in Acute Brain Injury

Tu, Tianqi; Peng, Jianhua; Jiang, Yong

doi:10.1089/scd.2019.0232

Cited by 19 publications

(10 citation statements)

References 127 publications

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“…The distribution of irisin can also be detected in different brain regions and cell groups such as in Purkinje cells in the cerebellum (Varela-Rodríguez et al, 2016), astrocytes in the hippocampus (Piya et al, 2014), neurons in the brain , the hypothalamus (Dun et al, 2013), and even cerebrospinal fluid (CSF) (Aydin et al, 2013). Importantly, irisin has been demonstrated to have pivotal roles in attenuating inflammation, reducing oxidative stress, and alleviating apoptosis, as well as ameliorating mitochondrial dysfunction (Tu et al, 2020). Consequently, the discovery and distribution of irisin has provided a theoretical basis for exploring its effects in many diseases, especially in ischemic stroke.…”

Section: Structure and Distribution Of Irisinmentioning

confidence: 99%

The Neuroprotective Effect of Irisin in Ischemic Stroke

Liu

Zhu

Guo

et al. 2020

Front. Aging Neurosci.

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Irisin is a PGC-1α-dependent myokine that causes increased energy expenditure by driving the development of white adipose tissue into brown fat-like tissue. Exercise can improve irisin levels and lead to its release into the blood. In ischemic stroke, neurons are always sensitive to energy supply; after a series of pathophysiological processes, reactive oxygen species that are detrimental to cell survival via mitochondrial dysfunction are generated in large quantities. As a protein associated with exercise, irisin can alleviate brain injury in the pathogenesis of ischemic stroke. It is thought that irisin can upregulate the levels of brain-derived neurotrophic factor (BDNF), which protects nerve cells from injury during ischemic stroke. Furthermore, the release of irisin into the blood via exercise influences the mitochondrial dynamics crucial to maintaining the normal function of nerve cells. Consequently, we intended to summarize the known effects of irisin during ischemic stroke.

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Section: Structure and Distribution Of Irisinmentioning

confidence: 99%

The Neuroprotective Effect of Irisin in Ischemic Stroke

Liu

Zhu

Guo

et al. 2020

Front. Aging Neurosci.

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“…Besides, irisin performed a protective function on lipid metabolism involving several pathways such as the AMPK-SREBP2 pathway ( Tang et al, 2016 ). It was also antioxidative, anti-inflammatory, and attenuating apoptosis, functioning to alleviate mitochondrial dysfunction ( Mazur-Bialy et al, 2017b ; Tu et al, 2020 ; Zhang et al, 2020 ). Many studies have reported that irisin had neuroprotective functions in AD ( Kim and Song, 2018 ; Lourenco et al, 2019 ; de Freitas et al, 2020 ).…”

Section: Introductionmentioning

confidence: 99%

Effects of the FNDC5/Irisin on Elderly Dementia and Cognitive Impairment

Peng

2022

Front. Aging Neurosci.

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Population aging is an inevitable problem nowadays, and the elderly are going through a lot of geriatric symptoms, especially cognitive impairment. Irisin, an exercise-stimulating cleaved product from transmembrane fibronectin type III domain-containing protein 5 (FNDC5), has been linked with favorable effects on many metabolic diseases. Recently, mounting studies also highlighted the neuroprotective effects of irisin on dementia. The current evidence remains uncertain, and few clinical trials have been undertaken to limit its clinical practice. Therefore, we provided an overview of current scientific knowledge focusing on the preventive mechanisms of irisin on senile cognitive decline and dementia, in terms of the possible connections between irisin and neurogenesis, neuroinflammation, oxidative stress, and dementia-related diseases. This study summarized the recent advances and ongoing studies, aiming to provide a better scope into the effectiveness of irisin on dementia progression, as well as a mediator of muscle brain cross talk to provide theoretical support for exercise therapy for patients with dementia. Whether irisin is a diagnostic or prognostic factor for dementia needs more researches.

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“…Irisin, a hormone-like myokine with neurotrophic effects, has also been reported to induce beneficial effects after stroke, including inhibited post-ischemic inflammation, reduced oxidative stress and improved mitochondrial function [ 14 ]. In fact, decreased concentrations of irisin are associated with poor functional outcome in ischemic stroke [ 15 ].…”

Section: Introductionmentioning

confidence: 99%