FNAC of nodular fasciitis mimicking a pleomorphic adenoma: another diagnostic pitfall

Silvanto, Anna; Melly, Lucy; Hannan, S. A.; Kocjan, G

doi:10.1111/j.1365-2303.2009.00706.x

Cited by 9 publications

(3 citation statements)

References 5 publications

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“…[1][2][3] This deceptive histological appearance may result in erroneous diagnoses and inadequate treatment. [4][5][6] Since its initial description by Konwaler et al, 7 the neoplastic nature of NF has been debated. [8][9][10][11] Although a few studies showed evidence that at least a subset of NF were clonal in nature, others were unable to confirm these findings.…”

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confidence: 99%

Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion

Erickson-Johnson

Chou

Evers

et al. 2011

Laboratory Investigation

332

246

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Nodular fasciitis (NF) is a relatively common mass-forming and self-limited subcutaneous pseudosarcomatous myofibroblastic proliferation of unknown pathogenesis. Due to its rapid growth and high mitotic activity, NF is often misdiagnosed as a sarcoma. While studying the USP6 biology in aneurysmal bone cyst and other mesenchymal tumors, we identified high expression levels of USP6 mRNA in two examples of NF. This finding led us to further examine the mechanisms underlying USP6 overexpression in these lesions. Upon subsequent investigation, genomic rearrangements of the USP6 locus were found in 92% (44 of 48) of NF. Rapid amplification of 5 0 -cDNA ends identified MYH9 as the translocation partner. RT-PCR and direct sequencing revealed the fusion of the MYH9 promoter region to the entire coding region of USP6. Control tumors and tissues were negative for this fusion. Xenografts of cells overexpressing USP6 in nude mice exhibited clinical and histological features similar to human NF. The identification of a sensitive and specific abnormality in NF holds the potential to be used diagnostically. Considering the self-limited nature of the lesion, NF may represent a model of 'transient neoplasia', as it is, to our knowledge, the first example of a self-limited human disease characterized by a recurrent somatic gene fusion event.

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confidence: 99%

Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion

Erickson-Johnson

Chou

Evers

et al. 2011

Laboratory Investigation

332

246

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“…NF has a very variable histology (Kong and Cha, 2004) and sometimes, it is histologically very difficult to distinguish NF from an atypical form of granulation tissue (Plaza et al, 2005) or even mimicking a benign tumour (Silvanto et al, 2009). Small needle aspirate may be insufficient for special staining and for further immunohistochemical studies.…”

Section: Discussionmentioning

confidence: 99%

Unusual presentation of nodular fasciitis as a rapidly growing haemorrhagic temporal mass

Jovanović

Čvorović

Milosevic

et al. 2012

Journal of Cranio-Maxillofacial Surgery

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“…Nodular fasciitis is characterized primarily by the presence of spindle cells with appreciable anisonucleosis and multinucleation. 6 Buckling of slender nuclei can be seen in at least some cells in an aspirate from benign nerve sheath tumours. Malignancy usually does not pose a problem as cytological features are obvious.…”

Section: Cytomorphology Of Chondroid Syringomamentioning

confidence: 99%

Cytomorphology of Chondroid Syringoma: Analysis of 20 Cases and Review of Literature

Agrawal¹,

Singh²,

.³

et al. 2019

APALM

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Background: Chondroid syringomas [CS] are interesting skin adnexal tumours. They have a remarkable pleomorphic-adenoma like morphology in the skin. Though the histopathology of the tumour has been described in detail in literature, cytomorphological studies are restricted to case reports and small case series. For diagnosing a CS on cytology, the index of suspicion must be high, clinical evaluation must be thorough and knowledge of variant existing morphologies is essential.Aim: This study was done with the aim of studying the common and variant cytological features of chondroid syringomas. Methods:This was a retrospective study conducted over a four-year period in the Department of Pathology, VMMC and Safdarjung hospital. Fine needle aspirate smears and biopsy slides were studied. Morphological details were independently reviewed in detail by two pathologists (Dr MS and Dr MA). Result and Conclusion:The conventional biphasic cell morphology of CS was seen in nearly 50% cases. Rest of the cases showed predominance of one or more variant features in few areas and thus CS was only one of the differential diagnosis in these cases. Nevertheless, FNA proved to be fast, inexpensive and a reliable method for diagnosis of chondroid syringoma.The study will be relevant and helpful in the day to day cytological reporting of CS.

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FNAC of nodular fasciitis mimicking a pleomorphic adenoma: another diagnostic pitfall

Cited by 9 publications

References 5 publications

Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion

Nodular fasciitis: a novel model of transient neoplasia induced by MYH9-USP6 gene fusion

Unusual presentation of nodular fasciitis as a rapidly growing haemorrhagic temporal mass

Cytomorphology of Chondroid Syringoma: Analysis of 20 Cases and Review of Literature

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