FN1, Collagen, MMP-2, and Lumican Associated with ECM Organization with Multiple Signaling Pathways Dysfunction in Schizophrenia Pathogenesis by Network Biology Approaches
Abstract:Schizophrenia (SZ) is a chronic and devastating mental illness that affects around 20 million individuals worldwide. Cognitive deficits and structural and functional changes of the brain, abnormalities of brain ECM components, chronic neuroinflammation, and devastating clinical manifestation during SZ are likely etiological factors shown by affected individuals. However, the pathophysiological events associated with multiple regulatory pathways involved in the brain of this complex disorder are still unclear. … Show more
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