fMRI shows multiple somatotopic digit representations in human primary somatosensory cortex

Kurth, Ralf; Villringer, Kersten; Curio, Gabriel; Kj, Wolf; Krause, Thomas; Repenthin, Jonas; Schwiemann, Jessica; Deuchert, Michael; Villringer, Arno

doi:10.1097/00001756-200005150-00026

Cited by 128 publications

(85 citation statements)

References 6 publications

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“…The right images in Figure 4 shows the result obtained with the anatomic landmark approach, mapped onto the brain of the generic head model. For both methods we see the location of the activation clusters posterior to the central sulcus and in good agreement to the known somatotopic finger representation with the first finger anterior and inferior to the fifth finger [19][20][21][22]. Due to the slight difference in the optode position (mean lateral difference (y-direction) in this subject was 5mm) the results for both approaches are rather similar.…”

Section: Resultssupporting

confidence: 80%

Three-dimensional superposition of diffuse optical tomography results and subjacent anatomic structures

et al. 2011

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Near infrared spectroscopy (NIRS) and diffuse optical tomography (DOT) reveal no information about the measurement's underlying anatomical structures. An independent anatomical mapping of DOT results onto the subject's brain or a generic brain model is desirable, especially when regions prone to large inter-subject variability are studied. We show two methods to match DOT data from high density fiber grids to anatomical structures. The forward model that is used to predict the light propagation is based on one generic anatomical MR scan. In both approaches we use this model MR-scan to translocate the position of the optical fiber grid from our experimental setup to the FEM model space. The fiducial mark approach uses the spatial normalization of the subject's MR-scan (with marked corners of the fiber grid) and the model's MR scan, leading to a translocation of the fiber pad position to the FEM-Model space. The anatomic landmark approach is used without individual MR scan. 19 reference points and the position of the fiber pad corners are determined using photogrammetry software. These coordinates are translocated to the FEM model space by solving the least square problem of the subject's and the model's reference points. We illustrate and compare both methods and show results from a vibrotactile stimulation experiment in humans.

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Section: Resultssupporting

confidence: 80%

Three-dimensional superposition of diffuse optical tomography results and subjacent anatomic structures

et al. 2011

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“…This will have to wait for the construction of a stimulation device with a higher nozzle count (Zappe et al, 2004) combined with higher resolution scans using a surface coil. Nevertheless, the repeated representation of particular face locations, lip locations, and finger locations in virtually every scan strongly suggests that there are multiple representations of the face, lips, and fingers in human SI (see also Blankenburg et al, 2003;Moore et al, 2000a;Kurth et al, 2000;Overduin and Servos, 2004;van Westen et al, 2004).…”

Section: Discussionmentioning

confidence: 99%

“…Studies using fMRI have revealed somatotopic representations of the hand, fingers, wrist, elbow, shoulder, foot, toes, lips, and tongue in human brains (Alkadhi et al, 2002;Beisteiner et al, 2001;Blankenburg et al, 2003;Dechent and Frahm, 2003;Francis et al, 2000;Gelnar et al, 1998;Golaszewski et al, 2006;Hanakawa et al, 2005;Hlustik et al, 2001;Kurth et al, 2000;Lotze et al, 2000;McGlone et al, 2002;Miyamoto et al, 2006;Moore et al, 2000a;Overduin and Servos, 2004;Ruben et al, 2001;Servos et al, 1998;Stippich et al, 1999Stippich et al, , 2004van Westen et al, 2004; also see reviews in Burton, 2002). The human face contains important sensory organs and is essential for verbal and nonverbal communications in daily life.…”

Section: Introductionmentioning

confidence: 99%

Dodecapus: An MR-compatible system for somatosensory stimulation

Huang

Sereno

2007

NeuroImage

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Somatotopic mapping of human body surface using fMRI is challenging. First, it is difficult to deliver tactile stimuli in the scanner. Second, multiple stimulators are often required to cover enough area of the complex-shaped body surface, such as the face. In this study, a computer-controlled pneumatic system was constructed to automatically deliver air puffs to 12 locations on the body surface through an MR-compatible manifold (Dodecapus) mounted on a head coil inside the scanner bore. The timing of each air-puff channel is completely programmable and this allows systematic and precise stimulation on multiple locations on the body surface during functional scans. Three two-condition block-design "Localizer" paradigms were employed to localize the cortical representations of the face, lips, and fingers, respectively. Three "Phase-encoded" paradigms were employed to map the detailed somatotopic organizations of the face, lips, and fingers following each "Localizer" paradigm. Multiple somatotopic representations of the face, lips, and fingers were localized and mapped in primary motor cortex (MI), ventral premotor cortex (PMv), polysensory zone (PZ), primary (SI) and secondary (SII) somatosensory cortex, parietal ventral area (PV) and 7b, as well as anterior and ventral intraparietal areas (AIP and VIP). The Dodecapus system is portable, easy to setup, generates no radio frequency interference, and can also be used for EEG and MEG experiments. This system could be useful for non-invasive somatotopic mapping in both basic and clinical studies.

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“…Since its beginning, fMRI has been able to distinguish major areas of the cortex (Belliveau, Kennedy, Jr. et al, 1991;Kim, Ashe et al, 1993;Hinke, Hu et al, 1993;Rao, Binder et al, 1993;Rueckert, Appollonio et al, 1994). Recently, a significant push for improving the spatial resolution of fMRI has allowed mapping of elemental functional units in the cortex, such as individual digits in motor/somatosensory cortex (Kurth, Villringer et al, 2000), ocular dominance columns in the visual cortex Goodyear and Menon, 2001;Cheng, Waggoner et al, 2001), individual whisker barrels (Yang, Hyder et al, 1996), and laminae of the olfactory bulb (Kida, Xu et al, 2002) and somatosensory cortex in rodents. In addition to fMRI, anatomical MRI techniques have also been used to obtain architectural information in the brain.…”

Section: Introductionmentioning

confidence: 99%

Detection of cortical laminar architecture using manganese-enhanced MRI

Silva

Lee

et al. 2008

Journal of Neuroscience Methods

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Changes in Manganese-Enhanced MRI (MEMRI) contrast across the rodent somatosensory cortex were compared to the cortical laminae as identified by tissue histology and administration of an anatomical tracer to cortex and thalamus. Across the cortical thickness, MEMRI signal intensity was low in layer I, increased in layer II, decreased in layer III until mid-layer IV, and increased again, peaking in layer V, before decreasing through layer VI. The reeler mouse mutant was used to confirm that the cortical alternation in MEMRI contrast was related to laminar architecture. Unlike in wildtype mice, the reeler cortex showed no appreciable changes in MEMRI signal, consistent[ACS1] with absence of cortical laminae in histological slides. The tract-tracing ability of MEMRI was used to further confirm assignments and demonstrate laminar specificity. Twelve to sixteen hours after stereotaxic injections of MnCl 2 to the ventroposterior thalamic nuclei, an overall increase in signal intensity was detected in primary somatosensory cortex compared to other brain regions. Maximum intensity projection images revealed a distinctly bright stripe located 600 − 700 μm below the pial surface, in layer IV. The data show that both systemic and tract-tracing forms of MEMRI are useful for studying laminar architecture in the brain.

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fMRI shows multiple somatotopic digit representations in human primary somatosensory cortex

Cited by 128 publications

References 6 publications

Three-dimensional superposition of diffuse optical tomography results and subjacent anatomic structures

Three-dimensional superposition of diffuse optical tomography results and subjacent anatomic structures

Dodecapus: An MR-compatible system for somatosensory stimulation

Detection of cortical laminar architecture using manganese-enhanced MRI

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