fMRI Response of Parietal Brain Areas to Sad Facial Stimuli in Mild Depression

Мельников, М. Е.; Петровский, Е. Д.; Безматерных, Д. Д.; Kozlova, L I; Штарк, М. Б.; Савелов, А. А.; Шубина, О. С.; Natarova, K A

doi:10.1007/s10517-018-4255-y

Cited by 16 publications

(13 citation statements)

References 12 publications

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“…Intriguingly, the HR and MDD groups showed reduced left amygdala connectivity with multiple brain regions (i.e., thalamus, STG, IPG, PreCG, and SMA), compared with the LR group. This is consistent with studies that found reduced activation or amygdala connectivity with these regions in individuals with depression (Mel’nikov et al., 2018) and risk for depression (Wackerhagen et al., 2017). The thalamus is known to relay sensory information to the amygdala in a fearful context (Penzo et al., 2015), thereby facilitating the amygdala to orchestrate the fear signaling system.…”

Section: Discussionsupporting

confidence: 91%

Reward‐ and threat‐related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil

Yoon

Rohrsetzer

Battel

et al. 2021

Child Psychology Psychiatry

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Background: Neuroimaging studies on adolescents at risk for depression have relied on a single risk factor and focused on adolescents in high-income countries. Using a composite risk score, this study aims to examine neural activity and connectivity associated with risk and presence of depression in adolescents in Brazil. Methods: Depression risk was defined with the Identifying Depression Early in Adolescence Risk Score (IDEA-RS), calculated using a prognostic model that included 11 socio-demographic risk factors. Adolescents recruited from schools in Porto Alegre were classified into a low-risk (i.e., low IDEA-RS and no lifetime depression), high-risk (i.e., high IDEA-RS and no lifetime depression), or clinically depressed group (i.e., high IDEA-RS and depression diagnosis). One hundred fifty adolescents underwent a functional MRI scan while completing a reward-related gambling and a threatrelated face-matching task. We compared group differences in activity and connectivity of the ventral striatum (VS) and amygdala during the gambling and face-matching tasks, respectively, and group differences in whole-brain neural activity. Results: Although there was no group difference in reward-related VS or threat-related amygdala activity, the depressed group showed elevated VS activity to punishment relative to high-risk adolescents. The wholebrain analysis found reduced reward-related activity in the lateral prefrontal cortex of patients and high-risk adolescents compared with low-risk adolescents. Compared with low-risk adolescents, high-risk and depressed adolescents showed reduced threat-related left amygdala connectivity with thalamus, superior temporal gyrus, inferior parietal gyrus, precentral gyrus, and supplementary motor area. Conclusions: We identified neural correlates associated with risk and presence of depression in a well-characterized sample of adolescents. These findings enhance knowledge of the neurobiological underpinnings of risk and presence of depression in Brazil. Future longitudinal studies are needed to examine whether the observed neural patterns of high-risk adolescents predict the development of depression.

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Section: Discussionsupporting

confidence: 91%

Reward‐ and threat‐related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil

Yoon

Rohrsetzer

Battel

et al. 2021

Child Psychology Psychiatry

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“…The angular gyrus is structurally connected to several brain areas including the frontal and parietal regions and the insular cortex. Against this background, we hypothesize that a reduction of cortical thickness in the angular gyrus might be responsible for its disconnection with a set of regions involved in emotion processing (43)(44)(45)(46)(47)(48)(49)(50) and might therefore account for deficits in emotion recognition. Moreover, we found negative correlations between cortical thickness of the precuneus and the severity of abnormal behavior in social situations (51)(52)(53).…”

Section: Discussionmentioning

confidence: 99%

Abnormal Cortical Thickness Is Associated With Deficits in Social Cognition in Patients With Myotonic Dystrophy Type 1

et al. 2020

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Aim: To investigate the cortical thickness in myotonic dystrophy type 1 (DM1) and its potential association with patients' genetic triplet expansion and social cognition deficits.Methods: Thirty patients with DM1 underwent the Social Cognition Battery Test and magnetic resonance imaging (MRI) scanning at 3 T. Twenty-five healthy subjects (HSs) were enrolled in the study to serve as a control group for structural MRI data. To assess changes in cortical thickness in DM1 patients, they were compared to HSs using a t-test model. Correlations were used to assess potential associations between genetic and clinical characteristics and social cognition performances in the patient group. Additionally, multiple regression models were used to explore associations between cortical thickness, CTG triplet expansion size, and scores obtained by DM1 patients on the Social Cognition Battery.Results: DM1 patients showed low performances in several subtests of the Social Cognition Battery. Specifically, they obtained pathological scores at Emotion Attribution Test (i.e., Sadness, Embarrassment, Happiness, and Anger) and at the Social Situations Test (i.e., recognition of normal situation, recognition of aberrant behavior). Significant negative correlations were found between CTG triplet expansion size and Embarrassment, and Severity of Aberrant Behavior. Similarly, a negative correlation was found between patients' MIRS scores and Sadness. DM1 patients compared to HSs showed reduced thickness in the right premotor cortex, angular gyrus, precuneus, and inferior parietal lobule. Significant associations were found between patients' CTG triplet expansion size and thickness in left postcentral gyrus and in the left primary somatosensory cortex, in the posterior cingulate cortex bilaterally, and in the right lingual gyrus. Finally, significant associations were found between cortical thickness and sadness in the superior temporal gyrus, the right precentral gyrus, the right angular gyrus, and the left medial frontal gyrus bilaterally. DM1 patients showed a negative correlation between cortical thickness in the bilateral precuneus and in the left lateral occipital cortex Serra et al. Social Cognition Deficits in DM1 Brains and performance at the Social Situations Test. Finally, DM1 patients showed a negative correlation between cortical thickness in the left precuneus and in the superior frontal gyrus and scores at the Moral Distinction Test.Discussion: The present study shows both cortical thickness changes in DM1 patients compared to controls and significant associations between cortical thickness and patients' social cognition performances. These data confirm the presence of widespread brain damages associated with cognitive impairment in DM1 patients.

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“…Anatomically, the AG has projections to the MCC (Vogt, 2005) that are functionally involved in cognitive emotion regulation (Kohn et al, 2014). Mel'nikov et al (2018) showed that the activity of the MCC and the left parietal lobule are reduced by negative emotional stimuli, which may be considered a potential diagnostic marker for depressive disorders and a target for neurofeedback. T2DM is known to be associated with an increased risk of depression (Musselman et al, 2003), and some studies suggest that the relationship between depression and T2DM is bi-directional or co-morbid (O'Connor et al, 2009).…”

Section: Discussionmentioning

confidence: 99%

Functional Disconnection of the Angular Gyrus Related to Cognitive Impairment in Patients With Type 2 Diabetes Mellitus

Zhang

Gao

et al. 2021

Front. Hum. Neurosci.

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Type 2 diabetes mellitus (T2DM) is related to a variety of cognitive impairments that may even progress to dementia. Studies have found the angular gyrus (AG) is a cross-modal integration hub that is involved in a variety of cognitive processes. However, few studies have focused on the patterns of resting-state functional connections (rsFCs) of the AG in patients with T2DM. This study explored the functional connection (FC) between the AG and the whole brain and the relationship between the FC and clinical/cognitive variables in patients with T2DM. 44 patients with T2DM and 43 sex-, age-, and education-matched healthy controls underwent resting-state fMRI and received neuropsychological assessments. Compared with the control group, the T2DM group showed abnormal rsFCs between the AG and multiple brain regions. The FC between the left AG and the left medial temporal lobe in the T2DM group was positively correlated with scores on the Montreal Cognitive Assessment, after a Bonferroni correction (r = 0.40, P = 0.009). Collectively, patients with T2DM have abnormal FCs between the AG and extensive brain regions that may be related to various cognitive processes.

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fMRI Response of Parietal Brain Areas to Sad Facial Stimuli in Mild Depression

Cited by 16 publications

References 12 publications

Reward‐ and threat‐related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil

Reward‐ and threat‐related neural function associated with risk and presence of depression in adolescents: a study using a composite risk score in Brazil

Abnormal Cortical Thickness Is Associated With Deficits in Social Cognition in Patients With Myotonic Dystrophy Type 1

Functional Disconnection of the Angular Gyrus Related to Cognitive Impairment in Patients With Type 2 Diabetes Mellitus

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