fMRI investigation on cue-induced smoking craving

Lim, Hyun Kook; Pae, Chi‐Un; Joo, Ra-Hyeong; Yoo, Seung‐Schik; Choi, Byung-Gil; Kim, Daijin; Lee, Chul; Lee, Chang-Uk

doi:10.1016/j.jpsychires.2004.08.004

Cited by 18 publications

(17 citation statements)

References 6 publications

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“…To our knowledge, though, only three studies have reported on the use of video cues to elicit cigarette craving (McBride et al, 2006;Lim et al, 2005;Shadel, Niaura, & Abrams, 2001). As expected, in these studies of smokers, exposure to smoking-related videos elicited craving reactions that were similar in magnitude to previously reported reactions using in vivo cues.…”

Section: Nih Public Accessmentioning

confidence: 99%

“…Studies, primarily among cocaine addicts (e. (Huston & Wright, 1983;Reeves et al, 1985;Singer, 1980), and that exposure to videos produces neurophysiological changes that mimic the effects of actually engaging in that behavior. Thus, video cue presentations are preferable.To our knowledge, though, only three studies have reported on the use of video cues to elicit cigarette craving (McBride et al, 2006;Lim et al, 2005;Shadel, Niaura, & Abrams, 2001). As expected, in these studies of smokers, exposure to smoking-related videos elicited craving reactions that were similar in magnitude to previously reported reactions using in vivo cues.…”

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confidence: 99%

“…Kosten et al, 2006), but also among alcoholics (e.g. Hermann et al, 2006) and smokers (McClernon, Hiott, Huettel, & Rose, 2005;Smolka et al, 2006;Lee, Lim, Wiederhold, & Graham, 2005;McBride, Barrett, Kelly, Aw, & Dagher, 2006;Lim et al, 2005), have revealed increased activity in the anterior cingulate gyrus, the orbitofrontal cortex, the temporal lobe, nucleus accumbens, the amygdala, and the ventral striatum in response to drug cues presented under laboratory conditions. The rapid development of this literature has engendered an acute need for alternative sets of cues that are compatible for presentation in an MRI environment.…”

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Smoking-related videos for use in cue-induced craving paradigms

Tong

Bovbjerg

Erblich

2007

Addictive Behaviors

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Environmental cues (e.g., the sight of a cigarette) have long been recognized as important triggers for craving in smokers. Available imaging technologies (e.g., fMRI) allow investigation of the neural mechanisms for cue-induced craving, but there stands a need for a cue-delivery system compatible with an MRI environment. We developed a standardized set of 24 high-resolution videos, 12 containing cigarette smoking scenes (e.g., lighting up), and 12 containing neutral scenes (e.g., reading a book), each 30 seconds long, with comparable lighting, visual complexity, and background filmed by a professional cinematographer. Study participants were 20 smokers (mean age=37.7 years, 50% female). Each was exposed to the 24 videos in a random order under laboratory conditions. Dependent measures included heart rate, blood pressure, skin conductance, skin temperature, and self-reported craving (0-100) following each video. Overall findings indicated that smokers had greater reactivity to the smoking videos than to neutral videos (p<.01). Follow-up univariate analyses revealed significant cue effects on self-reported craving, galvanic skin response, and skin temperature. Interestingly, exploratory examination of gender revealed that men had higher blood pressure and skin temperature responses than women, and that women had higher responses when viewing videos of women smoking than when viewing men smoking. Results support this set of videos as an effective tool for investigation of cue-elicited craving, and raise the possibility of unique gender effects in cue reactivity. KeywordsCue-reactivity; Craving; Nicotine; Smoking; Video Cigarette smoking continues to pose a major worldwide public health threat (American Cancer Society [ACS], 2006). While some gains have been made in reducing the initiation of smoking in various targeted groups, cessation rates have increased little in the past decade in spite of numerous widely available intervention strategies (e.g., nicotine replacement) to smokers (ACS, 2006). Indeed, estimates indicate that across the United States, of those who attempt to quit, only 4.7% remain abstinent at one year post-cessation (ACS, 2006).In considering the factors that make successful cessation so difficult, studies over the past decade have pointed to a preeminent role of environmental cues (e.g., sight or smell of cigarettes) that can trigger strong cravings or urges, long after the acute effects of nicotine withdrawal have subsided (Carter & Tiffany, 1999). These cue-induced craving reactions have been modeled reliably under laboratory conditions with smokers experimentally exposed to Correspondence can be sent to Dr. Erblich at: Department of Oncological Sciences, Mount Sinai School of Medicine, One Gustave L. Levy Place, Box 1130, New York, NY 10029, Telephone: 212-659-5516, Facsimile: 212-659-5507, Email: joel.erblich@mssm.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early...

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Section: Nih Public Accessmentioning

confidence: 99%

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confidence: 99%

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Smoking-related videos for use in cue-induced craving paradigms

Tong

Bovbjerg

Erblich

2007

Addictive Behaviors

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“…Among the structures identified, the amygdala is perhaps the most important brain area in the unawareness processing of emotional information [Etkin et al, 2004;Killgore and Yurgelun-Todd, 2004;LeDoux, 1996LeDoux, , 2000Whalen et al, 1998Whalen et al, , 2004 along with the anterior cingulate cortex (ACC) [David et al, 2005;Gallagher and Frith, 2003;Killgore and Yurgelun-Todd, 2004;LeDoux, 2000]. Additionally, the amygdala and the ACC are also the most commonly reported loci of activation induced by drugrelated cues in brain-imaging studies [Brody et al, 2004;David et al, 2005;Franklin et al, 2007;Lee et al, 2005;Lim et al, 2005;McBride et al, 2006;Wilson et al, 2004Wilson et al, , 2005. For example, Due et al, [2002] reported that neural substrates are modulated by explicit visual smokingrelated cues in smokers.…”

Section: Introductionmentioning

confidence: 99%

Masked smoking‐related images modulate brain activity in smokers

Zhang¹,

Chen²,

Yu³

et al. 2008

Human Brain Mapping

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The questions of whether and how indiscriminate drug-related stimuli could influence drug-users are important to our understanding of addictive behavior, but the answers are still inconclusive. In the present preliminary functional magnetic resonance imaging study using a backward masking paradigm, the effect of indiscriminate smoking-related stimuli on 10 smokers and 10 nonsmokers was examined. The BOLD response showed a significant reduction (P = 0.001) in the right amygdala of smokers when they viewed but did not perceive masked smoking-related stimuli, while no significant differences were found in the nonsmoker group. More voxels in anterior cingulate cortex were negatively correlated with the amygdala during the masked smoking-related picture condition in smokers but not in nonsmokers, whereas more positively correlated voxels were observed during the masked neutral condition. The BOLD response in drug-users indicates the amygdala responds to drug-related stimuli that are below the perceptual threshold. The functional connectivity data suggest a functional interaction between the amygdala and the anterior cingulate cortex when drug users view 33 ms back-masked drug-related stimuli. This observation suggests that the amygdala plays an important role in the indiscriminate drug-related cue process.

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“…Este circuito finaliza en la Corteza Orbitofrontal, que sería en última instancia la responsable del control conductual. Diferentes estudios indican que la impulsividad conductual observada en fumadores bajo estado de craving se debe a la ausencia de inhibición de la Corteza Orbitofrontal sobre la conducta, (Field, Rush, Cole y Goudie, 2007;Lim et al, 2005; Gloria, Angelos, Schaefer, Davis, Majeskie, Richmond y Baker, 2009).…”

Section: Mecanismos De Toma De Decisionesunclassified

Aspectos neuropsicológicos del craving por la nicotina

Muñoz¹,

Sanjuan²,

Fernández‐Santaella³

et al. 2011

Adicciones

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Craving has been defined as the motivation to self-administer a substance previously consumed. It has been hypothesized that craving contributes significantly to compulsive drug use and relapse after a period of abstinence in humans. Neuropsychological and brain-imaging studies have identified numerous brain regions that may be involved in craving. In this paper, the neuropsychological mechanisms of craving for nicotine are reviewed, focusing on three systems that appear to be involved in craving states. First of all, the reward system, responsible for the development of dependence and craving. Secondly, the emotional and associative system, which is related to conditioned craving. And third, the system involved in the neural basis of cognitive and decisionmaking processes. The most influential theoretical models on craving are also reviewed, including those based on conditioning mechanisms, on cognitive mechanisms and on cognitive-behavioral mechanisms, as well as the neurobiological model. Factors related to the evaluation and treatment of craving are also discussed, with particular emphasis on clinical aspects. Finally, we stress the importance of a multidisciplinary approach for achieving a common model on craving and improving the diagnostic tools and treatment strategies.Key words: craving, smoking, neuropsychological mechanisms, nicotine dependence, theoretical models. RESUMEN ABSTRACTEl craving se ha definido como la motivación de autoadministrarse una sustancia que previamente ha sido consumida. Se considera que el craving es responsable del consumo compulsivo de una sustancia, así como del alto nivel de recaídas después de periodos de abstinencia. Los estudios neuropsicológicos y de imagen cerebral han identificado numerosas regiones cerebrales implicadas en el craving. En este artículo se revisan los mecanismos neuropsicológicos implicados en el craving por la nicotina, centrándose en los tres sistemas involucrados en el craving. Primero, el sistema de recompensa, responsable del desarrollo de la dependencia y del craving. Segundo, el sistema emocional y asociativo que se relaciona con el craving condicionado. Tercero, el sistema implicado en la toma de decisiones y procesos cognitivos. Además, se revisa los modelos teóri-cos más influyentes, como los Modelos basados en el Condicionamiento, Modelos Cognitivo-Conductuales, Modelos Cognitivos y Modelo Neurobiológico. También se discuten otros aspectos relacionados con la evaluación y tratamiento del craving, haciendo énfasis en los aspectos clínicos. Como conclusión, se acentúa la importancia de un enfoque multidisciplinar para lograr un modelo común del craving, así como para mejorar las herramientas diagnósticas y las estrategias de tratamiento.

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fMRI investigation on cue-induced smoking craving

Cited by 18 publications

References 6 publications

Smoking-related videos for use in cue-induced craving paradigms

Smoking-related videos for use in cue-induced craving paradigms

Masked smoking‐related images modulate brain activity in smokers

Aspectos neuropsicológicos del craving por la nicotina

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