fMRI Findings in Cortical Brain Networks Interactions in Migraine Following Repetitive Transcranial Magnetic Stimulation

Markin, Kirill; Trufanov, A. G.; Frunza, Daria; Litvinenko, Igor; Тарумов, Д. А.; Krasichkov, Alexander; Polyakova, V. O.; Ефимцев, А. Ю.; Medvedev, Dmitry

doi:10.3389/fneur.2022.915346

Cited by 3 publications

(3 citation statements)

References 40 publications

(50 reference statements)

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“…The study conducted by Markin et al . [ 73 ] showed that the application of repetitive Transcranial Magnetic Stimulation (rTMS) for five days in 19 migraine patients was associated with FC changes within the default mode, salience and visual networks, which have been implicated in migraine pathophysiology.…”

Section: Resultsmentioning

confidence: 99%

“…Another non-invasive neuromodulation method is the tDCS, which modulates the cortical activity by applying an excitatory or inhibitory electric current to the scalp [ 102 ]. Only two studies [ 73 , 74 ] have investigated functional and structural brain changes related to rTMS and tDCS treatments. The small sample size of these studies, the lack of a control group and the use of an uncorrected statistical threshold disallow solid conclusions regarding central modifications related to these treatments.…”

Section: Discussionmentioning

confidence: 99%

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Imaging the brain and vascular reactions to headache treatments: a systematic review

et al. 2023

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Background Neuroimaging studies have made an important contribution to our understanding of headache pathophysiology. This systematic review aims to provide a comprehensive overview and critical appraisal of mechanisms of actions of headache treatments and potential biomarkers of treatment response disclosed by imaging studies. Main body We performed a systematic literature search on PubMed and Embase databases for imaging studies investigating central and vascular effects of pharmacological and non-pharmacological treatments used to abort and prevent headache attacks. Sixty-three studies were included in the final qualitative analysis. Of these, 54 investigated migraine patients, 4 cluster headache patients and 5 patients with medication overuse headache. Most studies used functional magnetic resonance imaging (MRI) (n = 33) or molecular imaging (n = 14). Eleven studies employed structural MRI and a few used arterial spin labeling (n = 3), magnetic resonance spectroscopy (n = 3) or magnetic resonance angiography (n = 2). Different imaging modalities were combined in eight studies. Despite of the variety of imaging approaches and results, some findings were consistent. This systematic review suggests that triptans may cross the blood–brain barrier to some extent, though perhaps not sufficiently to alter the intracranial cerebral blood flow. Acupuncture in migraine, neuromodulation in migraine and cluster headache patients, and medication withdrawal in patients with medication overuse headache could promote headache improvement by reverting headache-affected pain processing brain areas. Yet, there is currently no clear evidence for where each treatment acts, and no firm imaging predictors of efficacy. This is mainly due to a scarcity of studies and heterogeneous treatment schemes, study designs, subjects, and imaging techniques. In addition, most studies used small sample sizes and inadequate statistical approaches, which precludes generalizable conclusions. Conclusion Several aspects of headache treatments remain to be elucidated using imaging approaches, such as how pharmacological preventive therapies work, whether treatment-related brain changes may influence therapy effectiveness, and imaging biomarkers of clinical response. In the future, well-designed studies with homogeneous study populations, adequate sample sizes and statistical approaches are needed.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Imaging the brain and vascular reactions to headache treatments: a systematic review

et al. 2023

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“…Методика фМРТ в состоянии покоя позволяет оценить базовую активность мозга в отсутствие определенных сенсорных или когнитивных стимулов. С помощью данной методики стало возможным изучение функциональной коннективности головного мозга, которая представляется в виде так называемых функциональных связей между различными участками головного мозга с формированием рабочих сетей покоя [8,9].…”

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Functional magnetic resonance imaging of the brain in patients with insomnia: a prospective study

Trushina,

Borshevetskaya,

Grishchenkov

et al. 2024

Lučevaâ diagn. ter.

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INTRODUCTION: Insomnia is one of the most common sleep disorders, the interest of scientists in the occurrence and pathophysiology of insomnia is growing every year. In particular, the brain connectome and its changes in sleep disorders are being actively studied based on the data of resting state functional magnetic resonance imaging.OBJECTIVE: The study is to assess changes in brain connectomes in patients with chronic insomnia using functional magnetic resonance imaging.MATERIALS AND METHODS: 53 people took part in the study, of which 34 patients who applied for a somnologist’s appointment at the Almazov National Research Medical Center of the Ministry of Health of the Russian Federation were diagnosed with chronic insomnia, confirmed by polysomnography. All participants of the study had an MRI of the brain on tomographs with a magnetic field induction force of 3.0 Tl at two time points.Statistics: Statistical analysis of MRI data was performed using MathLab 2018a, CONN v1.7. Descriptive statistics, the Kolmogorov-Smirnov criterion were used to process the materials, depending on the characteristics of the data, the MannWhitney U-criterion and Pearson Chi-squared were used to analyze demographic data.RESULTS: The study, neuroimaging markers of insomnia were identified and changes in the functional networks of the brain were described in patients with insomnia and a group of healthy volunteers at different time points.DISCUSSION: The obtained functional data demonstrate ambiguous results. Both an increase and a decrease in the functional connectivity of the medial prefrontal cortex with the structures of the visual analyzer, an increase in functional connections with the temporal pole, in particular with the hippocampus, is determined, which indicates changes in the consolidation of visually encoded information. The relative limitation in this study can be considered the heterogeneity of the age composition of the group.CONCLUSSION: Resting state functional MRI of the brain is a key neuroimaging method in determining the functional connections of the brain in patients with sleep disorders, which allows us to establish a impairment of functional interaction between brain structures involved in the processes of falling asleep and maintaining sleep.

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Effects of repetitive transcranial magnetic stimulation and their underlying neural mechanisms evaluated with magnetic resonance imaging-based brain connectivity network analyses

Han¹,

Zhu²,

Luan³

et al. 2023

European Journal of Radiology Open

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fMRI Findings in Cortical Brain Networks Interactions in Migraine Following Repetitive Transcranial Magnetic Stimulation

Cited by 3 publications

References 40 publications

Imaging the brain and vascular reactions to headache treatments: a systematic review

Imaging the brain and vascular reactions to headache treatments: a systematic review

Functional magnetic resonance imaging of the brain in patients with insomnia: a prospective study

Effects of repetitive transcranial magnetic stimulation and their underlying neural mechanisms evaluated with magnetic resonance imaging-based brain connectivity network analyses

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