fMRI brain response during sentence reading comprehension in children with benign epilepsy with centro-temporal spikes

Malfait, Domitille; Tucholka, Alan; Mendizabal, Sandrine; Tremblay, Julie; Poulin, Chantal; Oskoui, Maryam; Srour, Myriam; Carmant, Lionel; Major, Philippe; Lippé, Sarah

doi:10.1016/j.eplepsyres.2015.08.009

Cited by 20 publications

(21 citation statements)

References 90 publications

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“…The between-group results of cortical gyrification are generally in line with those of previous neuroimaging studies. The bilaterally increased gyrification in the Sylvian fissures was consistent with cortical thickness ( 14 ) and volumetric changes of gray matter ( 43 ), aberrant language recruitment using task paradigms ( 11 ), and altered functional connectivity and local intrinsic brain activity measured using resting-state fMRI in previous studies ( 10 , 12 , 15 – 19 , 21 – 24 , 44 ). For example, as shown in recent morphometric studies, children with BECTS have a thinner cortex in the frontal, temporal, and occipital regions and exhibit sparse (atypical) maturation of cortical thickness during development ( 14 ) as well as increased gray matter in the striatum and fronto–temporo–parietal cortex (striato–cortical circuit) ( 3 , 43 ).…”

Section: Discussionsupporting

confidence: 71%

Structural Covariance Network of Cortical Gyrification in Benign Childhood Epilepsy with Centrotemporal Spikes

Jiang

Zhang

et al. 2018

Front. Neurol.

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Benign childhood epilepsy with centrotemporal spikes (BECTS) is associated with cognitive and language problems. According to recent studies, disruptions in brain structure and function in children with BECTS are beyond a Rolandic focus, suggesting atypical cortical development. However, previous studies utilizing surface-based metrics (e.g., cortical gyrification) and their structural covariance networks at high resolution in children with BECTS are limited. Twenty-six children with BECTS (15 males/11 females; 10.35 ± 2.91 years) and 26 demographically matched controls (15 males/11 females; 11.35 ± 2.51 years) were included in this study and subjected to high-resolution structural brain MRI scans. The gyrification index was calculated, and structural brain networks were reconstructed based on the covariance of the cortical folding. In the BECTS group, significantly increased gyrification was observed in the bilateral Sylvain fissures and the left pars triangularis, temporal, rostral middle frontal, lateral orbitofrontal, and supramarginal areas (cluster-corrected p < 0.05). Global brain network measures were not significantly different between the groups; however, the nodal alterations were most pronounced in the insular, frontal, temporal, and occipital lobes (FDR corrected, p < 0.05). In children with BECTS, brain hubs increased in number and tended to shift to sensorimotor and temporal areas. Furthermore, we observed significantly positive relationships between the gyrification index and age (vertex p < 0.001, cluster-level correction) as well as duration of epilepsy (vertex p < 0.001, cluster-level correction). Our results suggest that BECTS may be a condition that features abnormal over-folding of the Sylvian fissures and uncoordinated development of structural wiring, disrupted nodal profiles of centrality, and shifted hub distribution, which potentially represents a neuroanatomical hallmark of BECTS in the developing brain.

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Section: Discussionsupporting

confidence: 71%

Structural Covariance Network of Cortical Gyrification in Benign Childhood Epilepsy with Centrotemporal Spikes

Jiang

Zhang

et al. 2018

Front. Neurol.

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“…Several authors have identified changes in children's reading skills, with low reading speed 6 18 19 and word reading accuracy. 18 20 21 Northcott et al 5 22 also identified difficulties in reading nonwords, Malfait et al 18 in reading texts and pseudowords, and Overvliet et al 23 in reading sentences and words, being nonetheless less evident on the latter. In two other studies, changes in the ability to read words aloud were also evident.…”

Section: Resultsmentioning

confidence: 99%

Writing and Reading Skills in Children with Benign Childhood Epilepsy with Centrotemporal Spikes: Systematic Review

Teixeira

Santos

Oom

2022

Journal of Pediatric Epilepsy

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In this study, we present the results from a systematic literature review that aimed to gather information about the writing and reading capacities of children with benign childhood epilepsy with centrotemporal spikes. This research comprises studies published between 2005 and 2016 in PubMed, Science Direct, and PsycInfo that included the keywords “benign childhood epilepsy with centrotemporal spikes”/ “rolandic epilepsy” with “written language”/ “reading” / “writing” / “literacy”/ “learning disabilities.” The study selection criteria were: (i) conducted with children with this epileptic syndrome aged between 5:11 and 16; (ii) involving children with active epilepsy or in remission; (iii) assessing written language or learning skills involving reading and writing; and (iv) published in journals with scientific refereeing. From the articles that met all the criteria defined, we compiled and synthesized the information about written language abilities. Reading problems appear to have higher incidence in this population, mostly with regard to the speed and reading accuracy and the ability to comprehend a written text. Fewer limitations were found in writing skills, but some studies showed difficulties in words writing, punctuation/ accentuation, and spontaneous writing coherence and cohesion. We also found disparities in the results regarding the relationship between writing skills and the clinical variables associated with epilepsy. Despite the heterogeneity of this population, it was possible to synthesize and define more precisely the written language variations presented. However, more concrete information is needed about written language disorders in this population, to present valid data to support clinical and pedagogical practices.

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“…The language, cognitive, and behavioral changes correspond with changes in the structural and functional neuroanatomy in children with BECTS. Such changes or anomalies are particularly visible in language networks, 65,[68][69][70]72,74,75,78,79,[81][82][83][84] and also in language and sensorimotor, 71,73,76,77,80 attentional, 85 and even social networks. 86 Given the abundance of data, the focus of this paragraph will be on a selection of studies that have been published in 2017 and 2018 only.…”

Section: Neuroimaging Findingsmentioning

confidence: 99%

“…Their results are generally in line with existing neuroimaging studies. [72][73][74]77,93,94,121,[123][124][125] Ciumas et al 86 investigated neuronal responses to emotional stimuli in 13 children with BECTS and 11 control subjects aged 6 to 12 years using event-related functional magnetic resonance imaging (fMRI). They were asked to discriminate between happy, fearful, scrambled, and neutral faces.…”

Section: Neuroimaging Findingsmentioning

confidence: 99%

“…18,25,27,39 In addition to that, intelligence quotient (IQ) is sometimes below the normal range, contrary to what was originally thought. 5, 17,22,[24][25][26][27][28]31,34,44,[48][49][50][61][62][63][64][65][66][67] Recent improvements in neuroimaging techniques have illustrated alterations in the language, 65,[68][69][70]72,74,75,78,79,[81][82][83][84] language and sensorimotor, 71,73,76,77,80 attentional, 85 and social networks 86 in the epileptic brain, as well as structural abnormalities, 63,76,[87][88][89]…”

Section: Introductionmentioning

confidence: 99%

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Impact of Rolandic Epilepsy on Language, Cognitive, and Behavioral Functioning in Children: A Review

Premchand

Tops

2018

J Pediatr Epilepsy

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The objective of this narrative review was to investigate how the clinical aspects, such as age-at-onset, epilepsy duration, centrotemporal spikes, spike location, and seizure frequency, affect various domains of language, cognition, and behavior in children with benign childhood epilepsy. Data were collected using various research databases, including Wiley Online Library, PubMed Central, Elsevier ClinicalKey, and Springer Complete Journals. Keywords such as “Benign Childhood Epilepsy” or “BECTS and language impairment” were used among other terms. Case reports, meta-analyses, and reviews were excluded. Children with benign childhood epilepsy are mainly impaired in semantic processing (receptive language), working memory, attention/inhibitory control, complex visuospatial skills, and social skills. Functional magnetic resonance imaging reveals not only structural abnormalities, but also alterations in language, sensorimotor, attentional, and social networks, suggesting long-term consequences. It so seems that the occurrence of centrotemporal spikes (with or without seizures), especially at a young age (below 6 years) and for an extended period of time, is the most meaningful contributor to the language, cognitive, and behavioral deficits in benign childhood epilepsy with centrotemporal spikes (BECTS), while the distribution of centrotemporal spikes (left, right, bilateral) seems of only little significance.

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fMRI brain response during sentence reading comprehension in children with benign epilepsy with centro-temporal spikes

Cited by 20 publications

References 90 publications

Structural Covariance Network of Cortical Gyrification in Benign Childhood Epilepsy with Centrotemporal Spikes

Structural Covariance Network of Cortical Gyrification in Benign Childhood Epilepsy with Centrotemporal Spikes

Writing and Reading Skills in Children with Benign Childhood Epilepsy with Centrotemporal Spikes: Systematic Review

Impact of Rolandic Epilepsy on Language, Cognitive, and Behavioral Functioning in Children: A Review

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