fMRI BOLD response to alcohol stimuli in alcohol dependent young women

Tapert, Susan F.; Brown, Gregory G.; Baratta, Michael V.; Brown, Sandra A.

doi:10.1016/j.addbeh.2003.07.003

Cited by 187 publications

(154 citation statements)

References 75 publications

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“…The pattern of activation with gustatory cues are consistent with the pattern observed in previous studies that have relied on visual cues (Tapert et al, 2004;Wrase et al, 2002) and a combination of gustatory and visual cues (Myrick et al, 2004). This study represents a novel contribution to the literature, because it is the first to report that appetitive control cues (eg juice) also significantly activate mesocorticolimbic structures in heavy drinkers, and more importantly, the first to report that it is the alcohol induced increase above and beyond this activation in response to normal appetitive cues that is strongly correlated with alcohol-related problems.…”

Section: Discussionsupporting

confidence: 90%

Exposure to the Taste of Alcohol Elicits Activation of the Mesocorticolimbic Neurocircuitry

Filbey

Claus

Audette

et al. 2007

Neuropsychopharmacol

248

216

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A growing number of imaging studies suggest that alcohol cues, mainly visual, elicit activation in mesocorticolimbic structures. Such findings are consistent with the growing recognition that these structures play an important role in the attribution of incentive salience and the pathophysiology of addiction. The present study investigated whether the presentation of alcohol taste cues can activate brain regions putatively involved in the acquisition and expression of incentive salience. Using functional magnetic resonance imaging, we recorded BOLD activity while delivering alcoholic tastes to 37 heavy drinking but otherwise healthy volunteers. The results yielded a pattern of BOLD activity in mesocorticolimbic structures (ie prefrontal cortex, striatum, ventral tegmental area/substantia nigra) relative to an appetitive control. Further analyses suggested strong connectivity between these structures during cue-elicited urge and demonstrated significant positive correlations with a measure of alcohol use problems (ie the Alcohol Use Disorders Identification Test). Thus, repeated exposure to the taste alcohol in the scanner elicits activation in mesocorticolimbic structures, and this activation is related to measures of urge and severity of alcohol problems.

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Section: Discussionsupporting

confidence: 90%

Exposure to the Taste of Alcohol Elicits Activation of the Mesocorticolimbic Neurocircuitry

Filbey

Claus

Audette

et al. 2007

Neuropsychopharmacol

248

216

View full text Add to dashboard Cite

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“…The reward circuits involve the dopamine projection from the ventral tegmental area (VTA) to striatal areas (e.g., nucleus accumbens) and the prefrontal cortex (PFC), the repeated activation of which underlies the attribution of incentive salience to otherwise neutral stimuli (28). Other reward-related areas, including the insula (29)(30)(31) and cingulate gyrus (8,14,15,29,(32)(33)(34)(35)(36), show increased activity with the presentation of drug-related stimuli. Presentation of these stimuli is also associated with increased activity in brain structures that underlie reward and emotion regulation, such as the thalamus (9,30,(37)(38)(39)(40) and amygdala (32,39).…”

mentioning

confidence: 99%

Marijuana craving in the brain

Filbey

Schacht

Myers

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

237

191

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Craving is one of the primary behavioral components of drug addiction, and cue-elicited craving is an especially powerful form of this construct. While cue-elicited craving and its underlying neurobiological mechanisms have been extensively studied with respect to alcohol and other drugs of abuse, the same cannot be said for marijuana. Cue-elicited craving for other drugs of abuse is associated with increased activity in a number of brain areas, particularly the reward pathway. This study used functional magnetic resonance imaging (fMRI) to examine cue-elicited craving for marijuana. Thirty-eight regular marijuana users abstained from use for 72 h and were presented with tactile marijuana-related and neutral cues while undergoing a fMRI scan. Several structures in the reward pathway, including the ventral tegmental area, thalamus, anterior cingulate, insula, and amygdala, demonstrated greater blood oxygen level dependent (BOLD) activation in response to the marijuana cue as compared with the neutral cue. These regions underlie motivated behavior and the attribution of incentive salience. Activation of the orbitofrontal cortex and nucleus accumbens was also positively correlated with problems related to marijuana use, such that greater BOLD activation was associated with greater number of items on a marijuana problem scale. Thus, cue-elicited craving for marijuana activates the reward neurocircuitry associated with the neuropathology of addiction, and the magnitude of activation of these structures is associated with severity of cannabis-related problems. These findings may inform the development of treatment strategies for cannabis dependence.cannabis ͉ cue ͉ fMRI ͉ reward

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“…Unfortunately, imaging results regarding cue-induced activity in the brain and subjective craving for alcohol or other drugs are not very consistent. Myrick and colleagues (2004) reported an association between the severity of craving and functional brain activation in the ventral striatum, orbitofrontal cortex and anterior cingulate cortex, while others described such a relationship for the dorsal striatum (Modell & Mountz, 1995) or the subcallosal gyrus (Tapert et al, 2004). Further studies were not able to identify any significant correlation between alcohol craving and cue-induced brain activation (Grüsser et al, 2004;Heinz et al, 2004b).…”

Section: Cravingmentioning

confidence: 99%

“…This brain region is considered to be involved in processes encoding the motivational value of a stimulus. Therefore, it is also of importance for attention and memory processes (Grüsser et al, 2004;Heinz et al, 2004b;Myrick et al, 2004;Tapert et al, 2004). 2.…”

Section: Neuroanatomical Core Structuresmentioning

confidence: 99%

“…Further studies were not able to identify any significant correlation between alcohol craving and cue-induced brain activation (Grüsser et al, 2004;Heinz et al, 2004b). Trying to understand these diverging findings, one has to take into account that all studies used different stimuli for craving induction: alcohol-related words (Tapert et al, 2004), alcohol-related pictures with (Myrick et al, 2004) or without (Grüsser et al, 2004) a sip of alcohol ("priming dose"). Furthermore, time point of examination differed from patients being not detoxified (Myrick et al, 2004) to detoxified patients in an inpatient treatment program (Braus et al, 2001;Grüsser et al, 2004;Heinz et al, 2004b;Heinz et al, 2007;Wrase et al, 2002;Wrase et al, 2007).…”

Section: Cravingmentioning

confidence: 99%

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