fMRI: blood oxygen level–dependent activation during a working memory–selective attention task in children born extremely preterm

Griffiths, Silja Torvik; Gundersen, Hilde; Neto, Emanuel; Elgen, Irene Bircow; Markestad, Trond; Aukland, Stein Magnus; Hugdahl, Kenneth

doi:10.1038/pr.2013.79

Cited by 33 publications

(45 citation statements)

References 42 publications

(56 reference statements)

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“…These results suggest this phase of maturation (7–9y) may represent a key transitional stage of working memory development. Support for this argument comes from a study of 11‐year‐old children born extremely preterm by Griffiths et al., which shows activation reductions compared with controls in frontal working memory areas, which belong to mature (as opposed to early) working memory networks 45. Preliminary evidence of a catch‐up of activation patterns comes from a study by Murner‐Lavanchy et al 46.…”

Section: Working Memorymentioning

confidence: 99%

Alterations in development of hippocampal and cortical memory mechanisms following very preterm birth

Nosarti

Froudist-Walsh

2016

Develop Med Child Neuro

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Deficits in memory function have been described in children and adolescents who were born very preterm (VPT), which can have profound effects on their school achievement and everyday life. However, to date, little is known about the development of the neuroanatomical substrates of memory following VPT birth. Here we focus on episodic and working memory and highlight key recent functional and structural magnetic resonance imaging (MRI) studies that have advanced our understanding of the relationship between alterations seen in the VPT brain and typical neurodevelopment of networks supporting these memory functions. We contrast evidence from the episodic and working memory literatures and suggest that knowledge gained from these functional and neuroanatomical studies may point to specific time windows in which working memory interventions may be most effective.

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Section: Working Memorymentioning

confidence: 99%

Alterations in development of hippocampal and cortical memory mechanisms following very preterm birth

Nosarti

Froudist-Walsh

2016

Develop Med Child Neuro

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“…143 Image processing and analysis using the SPM12 software package (or earlier versions) has been widely used in previous pediatric samples. 127,[144][145][146] Typical whole brain fMRI analyses using voxel-based methods, like the present study, include more than 50.000 voxels, resulting in numerous statistical tests. Consequently, corrections for multiple comparisons are important in all statistical analyses of fMRI data.…”

Section: Mri Measuresmentioning

confidence: 99%

“…We find it unlikely that the selection of a low birth weight group should explain the increased prefrontal activation seen in our opioid-exposed group, as decreased BOLD activation has been a consistent finding in fMRI studies of preterm and low birth weight groups, including one study using the same fMRI paradigm as the one used in the current study. 127 Birth weight has also been associated with neuropsychological functioning, including executive functions. 173 The group difference in task performance found in paper III was no longer significant after birth weight adjustment.…”

mentioning

confidence: 99%

Cerebral Magnetic Resonance Imaging in Children With Prenatal Drug Exposure

Sirnes

Elgen

Chong

et al. 2016

Clin Pediatr (Phila)

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This study aimed to evaluate cerebral magnetic resonance imaging (MRI) scans of children with prenatal drug exposure in a clinical context. A hospital-based cohort of 10- to 14-year-old children, prenatally exposed to alcohol, opioids, and polysubstances, and a group of sex- and age-matched controls were examined with cerebral MRI. Scans obtained from 34 exposed children and 40 controls were scored based on the presence and degree of pathology by an experienced pediatric neuroradiologist blinded to the participants’ background. Overall visual detectable MRI pathology was found in 35% of the exposed children and 33% of the controls (odds ratio = 1.08; 95% confidence interval = 0.36-3.25). No specific imaging pattern following prenatal drug exposure was seen by the means of simple visual analysis of cerebral MRI scans. Although cerebral MRI is feasible, it is probably of limited value in the clinical assessment of children with prenatal drug exposure.

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“…The disruption of the PFC has been suggested to be the underlying reason for behavioral symptoms of mental disorders such as Autism Spectrum Disorder (ASD) [21] [22] [23]. A variety of studies have examined PFC activity during executive-related tasks such as Go/No Go tasks [24], Verbal Fluency Tests [25] [26], the Stroop task [27] [28], N-back tasks [29] [30], and a combination of the Stroop task and an N-back task [31]. An event-related activation was found in the PFC during executive-related tasks.…”

Section: Introductionmentioning

confidence: 99%

Developmental and Condition-Related Changes in the Prefrontal Cortex Activity during Rest

Liang¹,

Chen²,

Shewokis³

et al. 2016

JBBS

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The prefrontal cortex (PFC) plays an important role in cognitive process related to executive function, but is also active during resting states. Quantifying prefrontal cortex activity during resting states provides a baseline for interpreting task-induced brain activity. Researchers commonly use resting conditions where participants are prompted to stare at a screen (eyes open) or close their eyes (eyes closed). Are these two conditions equivalent representations of a baseline resting state? Further, does prefrontal cortex activity during these conditions change as a function of development? The aim of this study was to examine differences in prefrontal cortex activity between eyes open and eyes closed conditions during resting states in children and adults to provide a rationale of proper selection of baseline condition in future research. Thirty-six participants in 3 age groups were recruited in this study including twenty-four adults, five 12 -15 years old children, and seven 8 -11 years old children. Relative changes in concentrations of oxygenated hemoglobin (Δoxy-Hb) and deoxygenated hemoglobin (Δdeoxy-Hb) were obtained by using functional Near-Infrared Spectroscopy (fNIRS) in eyes closed (EC) and eyes open (EO) conditions, 3 minutes each. Contrasts were tested to compare the differences of Δoxy-Hb and Δdeoxy-Hb between eyes open and eyes closed conditions. The EC condition had significantly higher Δoxy-Hb than EO when all groups were combined (t (17.268) = 3.021, p = .008, Cohen's d = −0.72). When comparing Δoxy-Hb between eyes conditions within each group, the younger group had significantly higher Δoxy-Hb in EC than EO (t (9.459) = 2.734, p = 0.022, Cohen's d = −1.46). Based on these results, the EO condition may be a better baseline condition, particularly in studies with younger children, since it has less activity in the PFC that could interfere with interpretations of task-induced activity.

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fMRI: blood oxygen level–dependent activation during a working memory–selective attention task in children born extremely preterm

Cited by 33 publications

References 42 publications

Alterations in development of hippocampal and cortical memory mechanisms following very preterm birth

Alterations in development of hippocampal and cortical memory mechanisms following very preterm birth

Cerebral Magnetic Resonance Imaging in Children With Prenatal Drug Exposure

Developmental and Condition-Related Changes in the Prefrontal Cortex Activity during Rest

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