“…As of 2019, there are over 300 original published studies with FDCR. These studies reported positive findings that FDCR in certain brain areas is associated with severity of the drug addiction (Sjoerds, van den Brink, Beekman, Penninx, & Veltman, 2014;Smolka et al, 2006), defines prognosis of long-term recovery (Janes et al, 2010;Kosten et al, 2006), predicts the response to specific interventions (Courtney, Schacht, Hutchison, Roche, & Ray, 2016;Mann et al, 2014) and can be used as a proxy measure for effectiveness of different interventions in clinical trials (Lukas et al, 2013;Sadraee, Paulus, & Ekhtiari, 2019).…”