FMD in the Andaman and Nicobar Islands

Hemadri, D.; Sanyal, Aniket; Tosh, C.; Rasool, T. J.; Bhattacharya, Shivaji; Pan, TingTing; Chattaopadhyay, A. P.; Bandyopadhyay, Alapan; Chakravarthy, J. L.; Negi, Arun; Bandyopadhyay, Santanu

doi:10.1136/vr.158.10.347-a

Cited by 2 publications

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“…Moreover, the risks associated with import of food supplies also may heighten the risks of disease. FMD was reported for a prolonged period in Andaman and Nicobar Islands in 2005 after a tsunami [169]. It was unclear whether the animals already had the virus that subsequently flared up upon the environmental stress or whether the virus originated in the materials used to package the relief supplies.…”

Section: Immunobiology Of Fmdv and Vaccine Failures: Challenges Anmentioning

confidence: 99%

Foot-and-Mouth Disease Virus: Immunobiology, Advances in Vaccines and Vaccination Strategies Addressing Vaccine Failures—An Indian Perspective

et al. 2019

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A mass vaccination campaign in India seeks to control and eventually eradicate foot-and-mouth disease (FMD). Biosanitary measures along with FMD monitoring are being conducted along with vaccination. The implementation of the FMD control program has drastically reduced the incidence of FMD. However, cases are still reported, even in regions where vaccination is carried out regularly. Control of FMD outbreaks is difficult when the virus remains in circulation in the vaccinated population. Various FMD risk factors have been identified that are responsible for FMD in vaccinated areas. The factors are discussed along with strategies to address these challenges. The current chemically inactivated trivalent vaccine formulation containing strains of serotype O, A, and Asia 1 has limitations including thermolability and induction of only short-term immunity. Advantages and disadvantages of several new-generation alternate vaccine formulations are discussed. It is unfeasible to study every incidence of FMD in vaccinated animals/areas in such a big country as India with its huge livestock population. However, at the same time, it is absolutely necessary to identify the precise reason for vaccination failure. Failure to vaccinate is one reason for the occurrence of FMD in vaccinated areas. FMD epidemiology, emerging and re-emerging virus strains, and serological status over the past 10 years are discussed to understand the impact of vaccination and incidences of vaccination failure in India. Other factors that are important in vaccination failure that we discuss include disrupted herd immunity, health status of animals, FMD carrier status, and FMD prevalence in other species. Recommendations to boost the search of alternate vaccine formulation, strengthen the veterinary infrastructure, bolster the real-time monitoring of FMD, as well as a detailed investigation and documentation of every case of vaccination failure are provided with the goal of refining the control program.

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Section: Immunobiology Of Fmdv and Vaccine Failures: Challenges Anmentioning

confidence: 99%

Foot-and-Mouth Disease Virus: Immunobiology, Advances in Vaccines and Vaccination Strategies Addressing Vaccine Failures—An Indian Perspective

et al. 2019

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“…Besides, FMD appeared in the Andaman and Nicobar Islands in May 2018 after a gap of almost 13 years (Sunder et al, 2019). Earlier, an FMD outbreak in the islands was recorded in March 2005 following a tsunami, the reason for which was speculated to be the relief materials sent from the mainland (Hemadri et al, 2006).…”

Section: Discussionmentioning

confidence: 99%

Genetic characterization of foot‐and‐mouth disease virus serotype O isolates collected during 2014–2018 revealed dominance of O/ME‐SA/Ind2001e and the emergence of a novel lineage in India

Dahiya

Subramaniam

Biswal

et al. 2020

Transbound Emerg Dis

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Foot-and-mouth disease (FMD) is endemic in India with a preponderance of outbreaks caused by FMD virus (FMDV) serotype O. Out of the 11 global topotypes of serotype O, only ME-SA topotype has been reported in the country so far. Lineage O/ME-SA/ Ind2001 and O/ME-SA/PanAsia are documented as the most dominant ones in terms of the number of outbreaks caused by them. To understand the distribution of topotype/lineages in India and their antigenic behaviour during the year 2014-2018, a total of 286 FMDV serotype O viral isolates were sequence determined at the VP1 region, and 109 isolates were characterized antigenically. All the isolates grouped in the ME-SA topotype, being distributed in lineage O/ME-SA/Ind2001 (within sublineages O/ME-SA/Ind2001d and O/ME-SA/Ind2001e), and a new group designated here as O/ME-SA/2018 cluster. The sub-lineage O/ME-SA/Ind2001e reported for the first time in India during the year 2015, replaced sub-lineage O/ME-SA/Ind2001d gradually, which was dominating since 2008. During the years 2014-2018, the sublineage O/ME-SA/Ind2001e was found to be the most predominant one whose mean evolutionary rate was observed to be faster than that of the sub-lineage O/ME-SA/ Ind2001d. The codon sites 45 and 85 of VP1 were found to be under diversifying selection in a large proportion of trees. The common ancestor predicted for sublineages O/ME-SA/Ind2001e and O/ME-SA/2018 dates back to 2012 and 2016, respectively. The sustenance and spread of the new O/ME-SA/2018 cluster need to be assessed by continued surveillance. The Indian vaccine strain O/INDR2/1975 was found to provide adequate antigenic coverage to the emerging and prevalent serotype O lineages. The trait association tests showed frequent virus exchange among different states, which could be an important confounder in the region-specific assessment of effectiveness of FMD control programme.

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FMD in the Andaman and Nicobar Islands

Cited by 2 publications

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Foot-and-Mouth Disease Virus: Immunobiology, Advances in Vaccines and Vaccination Strategies Addressing Vaccine Failures—An Indian Perspective

Foot-and-Mouth Disease Virus: Immunobiology, Advances in Vaccines and Vaccination Strategies Addressing Vaccine Failures—An Indian Perspective

Genetic characterization of foot‐and‐mouth disease virus serotype O isolates collected during 2014–2018 revealed dominance of O/ME‐SA/Ind2001e and the emergence of a novel lineage in India

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