Fluvastatin and Perioperative Events in Patients Undergoing Vascular Surgery

Schouten, Olaf; Boersma, Eric; Hoeks, Sanne E.; Benner, R.; Urk, Hero van; Sambeek, Marc R.H.M. van; Verhagen, Hence J.M.; Khan, Nisar Ahmad; Dunkelgrün, Martin; Bax, Jeroen J.; Poldermans, Don

doi:10.1056/nejmoa0808207

Cited by 324 publications

(151 citation statements)

References 24 publications

Supporting

Mentioning

132

Contrasting

Unclassified

Order By: Relevance

“…Additionally, evidence from randomized clinical trials and observational studies support its use in clinical practice. In the DECREASE-Ⅲ study a 53% reduction in CV death and myocardial infarction was seen with high-dose fluvastatin in patients undergoing vascular surgery [38] . In another trial of 100 patients randomly assigned to 20 mg of atorvastatin or placebo prior to vascular surgery, the use of statins was associated with a significant reduction in cardiac events, from 26% to 8% at 6 mo [39] .…”

Section: Management Of Perioperative Myocardial Infarctionmentioning

confidence: 98%

Perioperative clinical variables and long-term survival following vascular surgery

García¹

2014

WJC

View full text Add to dashboard Cite

Cardiovascular disease is the leading cause of death in patients with peripheral arterial disease (PAD). Coronary artery disease (CAD) is highly prevalent, and often times coexist, in patients with PAD. The management of patients with PAD that requires a high-risk vascular surgical procedure for intermittent claudication, critical limb ischemia or expanding abdominal aortic aneurysm requires risk stratification with the revised cardiac risk index, optimization of medical therapies, and limited use of cardiac imaging prior to surgery. Preventive revascularization in patients with stable CAD, with the sole intention to mitigate the risk of cardiac complications in the peri-operative period, is not effective and may be associated with significant bleeding and thrombotic risks, in particular if stents are used. A strategy of universal use of cardiac troponins in the perioperative period for active surveillance of myocardial ischemia may be more reasonable and cost-effective than the current standard of care of widespread use of cardiac imaging prior to high-risk surgery. An elevated cardiac troponin after vascular surgery is predictive of longterm mortality risk. Medical therapies such as aspirin and statins are recommended for patients with postoperative myocardial ischemia. Ongoing trials are assessing the role of novel anticoagulants. Additional research is needed to define the role of cardiac imaging and invasive angiography in this population.

show abstract

Section: Management Of Perioperative Myocardial Infarctionmentioning

confidence: 98%

Perioperative clinical variables and long-term survival following vascular surgery

García¹

2014

WJC

View full text Add to dashboard Cite

show abstract

“…Хотя абдоминальная аневризма аорты тоже относится к состоянию, эквивалентному ИБС, нет убедительных доказательств, что терапия статинами снижает периопера-ционную заболеваемость ССЗ у этих пациентов [220,487] . Польза ХС-снижающей терапии при атеросклерозе других типов артерий (почечных артерий) требует дальнейших доказательств [488] .…”

Section: пациенты с заболеваниями периферических артерийunclassified

A Ten Year Overview of Surgical and Interventional Arrhythmology in Russia. Service Peculiar Features in the Far East

Богачевская¹,

Bogachevskiy²

2017

Soc.Asp.Pop.Hlth

View full text Add to dashboard Cite

“…Lipid-lowering HMG-CoA reductase inhibitors (statins) stabilize vulnerable plaques, have anti-inflammatory effects, inhibit thrombosis formation, and can reduce the incidence of perioperative ischemia, (re)infarction, and mortality in patients with coronary risk [39,40]. Long-term statin therapy should therefore not be interrupted perioperatively.…”

Section: C3 Hmg-coa Reductase Inhibitors (Statins)mentioning

confidence: 99%

Preoperative evaluation of adult patients before elective, noncardiothoracic surgery

Zwißler

2017

Anaesthesist

View full text Add to dashboard Cite

Fluvastatin and Perioperative Events in Patients Undergoing Vascular Surgery

Abstract: In patients undergoing vascular surgery, perioperative fluvastatin therapy was associated with an improvement in postoperative cardiac outcome. (Current Controlled Trials number, ISRCTN83738615.)

Cited by 324 publications

References 24 publications

Perioperative clinical variables and long-term survival following vascular surgery

Perioperative clinical variables and long-term survival following vascular surgery

A Ten Year Overview of Surgical and Interventional Arrhythmology in Russia. Service Peculiar Features in the Far East

Preoperative evaluation of adult patients before elective, noncardiothoracic surgery

Contact Info

Product

Resources

About