Fluticasone furoate nasal spray: A single treatment option for the symptoms of seasonal allergic rhinitis

Kaiser, Harold B.; Naclerio, Robert M.; Given, John; Toler, T.; Ellsworth, Anna; Philpot, E.

doi:10.1016/j.jaci.2007.02.022

Cited by 136 publications

(107 citation statements)

References 23 publications

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“…[11][12][13][14][15][16] The mechanism by which it alleviates allergic conjunctivitis has yet to be fully elucidated. Possible mechanisms include: reduced nasal inflammation resulting in reduced release of inflammatory mediators and, hence, less activation of inflammatory cells in the neighboring tissues; improved drainage away from the eye down the nasolacrimal duct; and modulation of a nasoocular neurogenic reflex.…”

Section: Discussionmentioning

confidence: 99%

Isotonic nasal spray versus fluticasone nasal spray in treatment of allergic rhinitis

Gaddipatti¹,

Rao²,

Rajiv³

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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Background: Allergic rhinitis (AR) is a prevalent disease with great morbidity and causing signiﬁcant societal and economic burden. Aims and objectives: To compare efficacy of fluticasone nasal spray and isotonic saline nasal spray in allergic rhinitis.Methods: This was a prospective randomized study conducted on patients of allergic rhinitis coming to ENT OPD a tertiary care teaching hospital. Sixty patients diagnosed with concomitant diagnosis of allergic rhinitis was randomly allocated to either Fluticasone propionate nasal spray (n= 30) and isotonic saline spray (n= 30). Results: The most common age group in fluticasone group was 21 to 30 years while in isotonic saline group 31 to 40 years was the most common age group. There was 52.8% of female and 47.2% in fluticasone group while in isotonic saline group, 52.5% of study population were female and 47.5% were male. There was significant improvement in VAS on day 15 and day 30 as compared to day 1 in fluticasone treated subjects as compared to isotonic saline group. After one month, Nasal blockage, nasal discharge, sneezing, nasal itching was improved to 71%, 69%, 81% and 78% in fluticasone treated subjects as compared to isotonic saline group in which improvement was up to 11%, 17%, 09% and 12% respectively and this difference was statistically significant. Conclusions: Fluticasone nasal spray has the potential to enhance patient satisfaction and compliance and reduce the need for polypharmacy in the management of seasonal allergic rhinitis.

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Section: Discussionmentioning

confidence: 99%

Isotonic nasal spray versus fluticasone nasal spray in treatment of allergic rhinitis

Gaddipatti¹,

Rao²,

Rajiv³

et al. 2017

Int J Otorhinolaryngol Head Neck Surg

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“…FFNS has few systemic adverse effects due to its low bioavailability. Its significant efficacy in the relief of nasal symptoms, compared with placebo, has been demonstrated in adult and adolescent patients with SAR in double-blind, placebo-controlled studies19,34. An exposure chamber trial conducted by Zieglmayer et al 35.…”

Section: Discussionmentioning

confidence: 99%

“…Fluticasone furoate nasal spray (FFNS) is a novel enhanced-affinity intra-nasal corticosteroid that is administered once daily with the onset of symptom relief as early as 8 h and providing 24 h of symptom relief19. In addition, few systemic adverse effects have been reported, regardless of the duration of use, because of the low systemic bioavailability20.…”

Section: Introductionmentioning

confidence: 99%

Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber

Hashiguchi

Kanzaki

Wakabayashi

et al. 2013

Journal of Drug Assessment

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ObjectiveThis study investigated the clinical efficacy of a combination therapy of levocetirizine (LCTZ) and fluticasone furoate nasal spray (FFNS), compared with LCTZ monotherapy, for the suppression of seasonal allergic rhinitis (SAR) symptoms induced in an artificial exposure chamber.MethodsThis study was a single-center, placebo-controlled, randomized, 3-way cross-over comparative study performed in 42 Japanese cedar pollinosis patients. These subjects received (1) LCTZ plus FFNS (combination group), (2) LCTZ plus FFNS placebo (monotherapy group), or (3) LCTZ placebo plus FFNS placebo (placebo group) once on the night prior to exposure, with a 1-week washout period between exposures. Nasal (sneezing, rhinorrhea, nasal congestion, and itchy nose) and ocular (eye itching and tearing) symptoms were recorded every 15 min, and the number of sneezes, nose blowing events, and the amount of nasal secretions were measured during exposure. The primary end-point was the cumulative incidence of SAR symptoms during exposure and the ‘ime to occurrence of symptoms’. The secondary end-points were the total nasal symptom score, the ocular symptom score, the amount of nasal discharge, and the number of sneezes and nose blowing events.ResultsAt all the measurement points, the lowest cumulative incidences for the nasal symptoms were observed in the combination group, followed by the monotherapy and placebo groups. All the subjects in the placebo group developed nasal symptoms within 2 h after pollen exposure, while three and eight subjects in the monotherapy and combination groups, respectively, did not develop any nasal symptoms during exposure. In addition, combination therapy delayed the onset of symptoms.ConclusionsThe results demonstrated that combination therapy with FFNS and LCTZ significantly suppressed the induced SAR symptoms and delayed the onset of symptoms compared with LCTZ monotherapy and placebo. Although the conditions of the allergen challenge study using an exposure chamber are different from those in real life, combination therapy with FF and LCTZ was confirmed to be an effective treatment for SAR.

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“…The patients completed the total nasal symptom score (TNSS) survey, which assesses four AR symptoms: nasal obstruction, itching, rhinorrhoea, and sneezing [15,18]. The patients are asked to score each symptom from ''0'' to ''3'' based on symptom severity, where ''0'' meant no symptom and ''3'' meant very severe symptoms [15,18].…”

Section: Patient Selectionmentioning

confidence: 99%

“…The patients are asked to score each symptom from ''0'' to ''3'' based on symptom severity, where ''0'' meant no symptom and ''3'' meant very severe symptoms [15,18]. Patients with a TNSS score C6 were enrolled.…”

Section: Patient Selectionmentioning

confidence: 99%

The Effect of Medical Treatment on Voice Quality in Allergic Rhinitis

Develioğlu

Paltura

Koleli

et al. 2013

Indian J Otolaryngol Head Neck Surg

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To evaluate the change in the voice quality of patients with allergic rhinitis (AR) after medical treatment. The study enrolled 69 subjects: 39 with high serum-specific IgE levels to inhalant allergens as the study group and 30 healthy individuals as controls. All patients were evaluated using the total nasal symptom score (TNSS) and voice handicap index-10 (VHI-10) and then underwent an acoustic voice analysis. After 1 month of treatment with mometasone furoate nasal spray (two 50-lg puffs in each nostril once daily) and desloratadine (5-mg tablet once daily), the patients repeated the surveys and acoustic voice analysis. The results before and after treatment were compared. The TNSS and VHI-10 scores decreased significantly after treatment (p \ 0.01). After treatment, the acoustic analysis parameters improved significantly and were similar to the control group, and the maximum phonation time increased significantly (p \ 0.05). The voice quality of patients with AR is improved with medical treatment.

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Fluticasone furoate nasal spray: A single treatment option for the symptoms of seasonal allergic rhinitis

Cited by 136 publications

References 23 publications

Isotonic nasal spray versus fluticasone nasal spray in treatment of allergic rhinitis

Isotonic nasal spray versus fluticasone nasal spray in treatment of allergic rhinitis

Efficacy of fluticasone furoate nasal spray and levocetirizine in patients with Japanese cedar pollinosis subjected to an artificial exposure chamber

The Effect of Medical Treatment on Voice Quality in Allergic Rhinitis

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