Flurbiprofen microgranules for relief of sore throat: a randomised, double-blind trial

Russo, Marc; Bloch, Mark; Looze, Ferdinandus de; Morris, Christopher; Shephard, Adrian

doi:10.3399/bjgp13x663118

Cited by 35 publications

(55 citation statements)

References 19 publications

(22 reference statements)

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“…[22,23] In this study, flurbiprofen spray provided at least 30 minutes of at least moderate relief in a higher proportion of patients, and previously patient perception of at least moderate relief from acute pain has been shown to be clinically important. [28] Many patients visit physicians with sore throat and in a questionnaire-based study in Belgium, the top two reasons for visiting a doctor were to establish the cause (85.5%) and seek pain relief (84.5%); hopes for an antibiotic only ranked 11th out of 13 items (37.6%).…”

Section: Comparison With Existing Literaturementioning

confidence: 99%

“…[22] Assuming the same variability and similar efficacy of the spray, 244 patients per group were required to provide at least 90% power to demonstrate a difference between the treatments at the 5% significance level.…”

Section: Sample Sizementioning

confidence: 99%

“…[3,21] Previous studies have demonstrated the efficacy of flurbiprofen lozenge and granule formulations (8.75 mg per dose) for symptomatic relief of sore throat. [22][23][24] Recently, an innovative spray formulation containing 8.75 mg of flurbiprofen per dose has been developed for sore throat symptom relief. The spray formulation offers advantages such as rapid delivery to the affected area and is convenient to use.…”

Section: Introductionmentioning

confidence: 99%

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Efficacy of flurbiprofen 8.75 mg spray in patients with sore throat due to an upper respiratory tract infection: A randomised controlled trial

Looze

Russo²,

Bloch³

et al. 2016

European Journal of General Practice

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Pharyngitis (sore throat) is usually caused by viral infections; therefore, antibiotics are generally not warranted. Flurbiprofen 8.75 mg spray (maximum five doses/day, for three days) provides effective symptomatic relief. ABSTRACTBackground: Viral infections cause most cases of pharyngitis (sore throat); consequently, antibiotics are generally not warranted. However, a treatment targeting pain and inflammation, e.g. a topical non-steroidal anti-inflammatory spray, may be helpful for patients. Objective: To evaluate the efficacy and safety of flurbiprofen 8.75 mg spray. Methods: This randomised, double-blind, parallel group study was conducted at six communitybased clinical research centres in Australia and two in New Zealand. Adults with sore throat due to upper respiratory tract infection (onset four days) took one dose of flurbiprofen (n ¼ 249) or placebo spray (n ¼ 256); after six hours, they could re-dose every three-six hours as required, for three days (max. five doses/day). The primary endpoint was the area under the change from baseline curve in throat soreness from zero-two hours (AUC 0-2h ). The change from baseline in other sore throat symptoms also assessed efficacy. Results: The mean AUC 0-2h for throat soreness was significantly greater with flurbiprofen spray (À1.82; 95% CI: À1.98 to 1.65) compared with placebo (À1.13; 95% CI: À1.27 to 0.99) (P < 0.0001). Significantly greater reductions from baseline were observed with flurbiprofen spray compared with placebo from the first time-points assessed (five minutes for throat soreness/difficulty swallowing, 20 minutes for sore throat pain intensity and 30 minutes for swollen throat) for up to six hours (P < 0.05 for all). There was no significant difference in adverse events between treatment groups during the three-day study. Conclusion: Flurbiprofen spray provides rapid and long-lasting relief from sore throat symptoms, and is well-tolerated over three days.

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Section: Comparison With Existing Literaturementioning

confidence: 99%

Section: Sample Sizementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Efficacy of flurbiprofen 8.75 mg spray in patients with sore throat due to an upper respiratory tract infection: A randomised controlled trial

Looze

Russo²,

Bloch³

et al. 2016

European Journal of General Practice

Self Cite

View full text Add to dashboard Cite

show abstract

“…An exception to this is the management of pain associated with sore throat, which has been the object of several studies addressing the efficacy of NSAIDs (mostly ibuprofen, but also flurbiprofen, aceclofenac, diclofenac, nimesulide, tiaprofenic acid, and selective COX-2 inhibitors), analgesics-antipyretics (paracetamol and aspirin), and other types of drugs (corticosteroids, ambroxol). [5][6][7][8][9][10][11][12][13][14][15][16][17][18][19][20][21][22] Overall, these studies have demonstrated the efficacy of NSAIDs for the rapid relief of sore throat pain. Notably, in some of studies, NSAIDs were shown to be more effective pain relievers than paracetamol.…”

Section: Introductionmentioning

confidence: 99%

Efficacy and Safety of Morniflumate for the Treatment of Symptoms Associated with Soft Tissue Inflammation

Cremonesi

Cavalieri

2015

J Int Med Res

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The effectiveness of nonsteroidal antiinflammatory drugs (NSAIDs) for the management of pain in osteoarthritis and other musculoskeletal diseases is well documented. The role of NSAIDs is less clear in the treatment of conditions involving soft tissue inflammation, including the airways, earnose-throat (ENT) system and urogenital tract. These conditions are often treated inappropriately with antibiotics. Morniflumate, the ß-morpholinoethyl ester of niflumic acid, is a member of the fenamate family of NSAIDs indicated for the treatment of inflammatory conditions (with or without pain) affecting airways, the ENT system, urogenital tract and the osteoarticular system. Morniflumate has a 30-year history of clinical use, particularly for the treatment of pain associated with paediatric ENT infection. This article reviews evidence supporting the efficacy and safety of morniflumate. Based on available evidence and the favourable tolerability profile emerging from extensive clinical use, morniflumate appears to be a valid and well-tolerated alternative to other NSAIDs, or to antibiotics, for the treatment of pain and other symptoms of soft tissue inflammation.

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“…Thus, patients often use alternative remedies such as salt water gargles, throat spray, lozenges, or ice chips to alleviate their pain. 4,5 Auricular acupuncture is another modality that is reported to be effective at relieving many types of pain. Auricular acupuncture (placing needles in various points in the ear) is a form of integrative medicine in which particular points on the ear, when stimulated, are believed to correspond with specific areas of the body.…”

mentioning

confidence: 99%

Ear Acupuncture for Acute Sore Throat: A Randomized Controlled Trial

Moss

Crawford

2015

The Journal of the American Board of Family Medicine

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Background: Sore throat is a common cause of pain in outpatient encounters. Battlefield auricular acupuncture (the placing of needles in specific points in the ear) is a modality used to treat acute pain associated with a variety of ailments. The aim of our study was to determine whether auricular acupuncture reduces pain, medication usage, and missed work hours when added to standard therapy in adult patients with acute sore throat.Methods: We conducted an unblinded, pragmatic, randomized controlled trial among adult, nonpregnant patients presenting to an Air Force family medicine clinic with pain from acute sore throat. A total of 54 patients were followed for 48 hours after treatment.Results

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Flurbiprofen microgranules for relief of sore throat: a randomised, double-blind trial

Cited by 35 publications

References 19 publications

Efficacy of flurbiprofen 8.75 mg spray in patients with sore throat due to an upper respiratory tract infection: A randomised controlled trial

Efficacy of flurbiprofen 8.75 mg spray in patients with sore throat due to an upper respiratory tract infection: A randomised controlled trial

Efficacy and Safety of Morniflumate for the Treatment of Symptoms Associated with Soft Tissue Inflammation

Ear Acupuncture for Acute Sore Throat: A Randomized Controlled Trial

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