Flurbiprofen-induced stimulation of periosteal bone formation and inhibition of bone resorption in older rats

Jee, Webster S. S.; Li, X.J.; Li, Y.L.

doi:10.1016/8756-3282(88)90120-2

Cited by 26 publications

(5 citation statements)

References 22 publications

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“…Naproxen did not affect the BMD and Lmax, in the molar alveolar region and femoral midshaft, in SHAM rats. These findings are consistent with the studies which suggest that NSAIDs and N are not effective on normal bone tissue and development (Lane et al, 1990;Solheim et al;Jee et al, 1988). The reason for this is probably that there is no excessive prostaglandin production, which needs to be blocked in normal bone tissue.…”

Section: Discussionsupporting

confidence: 91%

The Effects of Ovariectomy and Naproxen Treatment on the Strength of Femoral Midshaft and Molar Alveolar Region in Rats

et al. 2009

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SUMMARY:The goal of the present study was to investigate the effects of ovariectomy and naproxen treatment on both femoral and mandibular bone mass and biomechanical competence. Sprague-Dawley rats were used and divided into five groups: baseline, sham ovariectomized, ovariectomized, sham ovariectomized + naproxen treatment, ovariectomized + naproxen treatment. Mandibles and femurs of the rats were extracted and bone mineral density of the extracted specimens were determined. The volumes and ash weights of the femurs and mandibles were estimated. Maximum loads of the femurs and mandibles were determined by using a three point bending test. Ovariectomy decreased bone mineral density of the femoral midshaft, however naproxen prevented this decrease. Neither ovariectomy nor naproxen treatment affected the BMD in the molar alveolar region. Maximum load was found significantly decreased in the femoral midshaft, however, naproxen treatment prevented this decrease. Maximum load of the molar alveolar region did not significantly change. Naproxen prevents the strength characteristics of femoral midshaft afforded by ovariectomy. However, neither ovariectomy nor naproxen has an effect on the molar alveolar region of the mandible.

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Section: Discussionsupporting

confidence: 91%

The Effects of Ovariectomy and Naproxen Treatment on the Strength of Femoral Midshaft and Molar Alveolar Region in Rats

et al. 2009

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“…With this in mind, NSAID have been shown, in some models at least, to exert a positive effect on bone mass. For example, flurbiprofen depresses bone resorption in young rats without lowering bone formation (Jee et al ., 1988) and decreases the resorption of bone in chronic destructive periodontal disease in beagles (Williams et al ., 1985).…”

Section: Bone Calcium and Osteoporosismentioning

confidence: 99%

Pharmacology and potential therapeutic applications of nitric oxide‐releasing non‐steroidal anti‐inflammatory and related nitric oxide‐donating drugs

Keeble

Moore

2002

British J Pharmacology

175

155

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This review examines the biological signi®cance, therapeutic potential and mechanism(s) of action of a range of nitric oxide-releasing non-steroidal anti-in¯ammatory drugs (NO-NSAID) and related nitric oxide-releasing donating drugs (NODD). The slow release of nitric oxide (NO) from these compounds leads to subtle changes in the pro®le of pharmacological activity of the parent, nonsteroidal anti-in¯ammatory drugs (NSAID). For example, compared with NSAID, NO-NSAID cause markedly diminished gastrointestinal toxicity and improved anti-in¯ammatory and antinociceptive ecacy. In addition, nitroparacetamol exhibits hepatoprotection as opposed to the hepatotoxic activity of paracetamol. The possibility that NO-NSAID or NODD may be of therapeutic bene®t in a wide variety of disease states including pain and in¯ammation, thrombosis and restenosis, neurodegenerative diseases of the central nervous system, colitis, cancer, urinary incontinence, liver disease, impotence, bronchial asthma and osteoporosis is discussed.

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“…The diaphyseal periosteum comprises morphologically separate layers, each representing different stages of osteogenesis and cell differentiation (15). Its outermost and innermost cell layers reflect osteoprogenitor and osteoblastic cell stages of differentiation, respectively (16,17). Many investigators have used these models to relate the onset of expression of specific cell surface receptors such as syndecan (18) and extracellular matrix markers such as bone sialoprotein (BSP) 1 (19) to morphological landmarks (and the underlying regulatory mechanisms) of intramembranous bone development.…”

mentioning

confidence: 99%

Extracellular Bone Acidic Glycoprotein-75 Defines Condensed Mesenchyme Regions to be Mineralized and Localizes with Bone Sialoprotein during Intramembranous Bone Formation

Gorski

Wang

Lovitch

et al. 2004

Journal of Biological Chemistry

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Bone acidic glycoprotein-75 is expressed very early during in vivo models of intramembranous bone formation, highly enriched in condensing osteogenic mesenchyme after marrow ablation and the osteoprogenitor layer of tibial periosteum. Bone sialoprotein accumulates within bone acidic glycoprotein-75-enriched matrix areas at a later stage in both models. Decalcification of initial sites of mineralization consistently revealed focal immunostaining for bone acidic glycoprotein-75 underneath these sites suggesting that mineralization occurs within bone acidic glycoprotein-75-enriched matrix areas. Ultrastructural immunolocalization of bone acidic glycoprotein-75 does not support a direct association with banded collagen fibrils, but rather suggests it is a component of a separate, amorphous scaffold occupying interfibrillar spaces. Double immunogold labeling demonstrated that a sizeable proportion of bone sialoprotein particles were located within a 50-nm radius of bone acidic glycoprotein-75. These results define bone acidic glycoprotein-75 as the earliest bone-restricted, extracellular marker of osteogenic mesenchyme. Based on this early bone-restricted expression pattern and a previously documented propensity of bone acidic glycoprotein-75 to form supramolecular complexes through self-association, bone acidic glycoprotein-75 may serve a key structural role in setting boundary limits of condensing osteogenic mesenchyme.

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Flurbiprofen-induced stimulation of periosteal bone formation and inhibition of bone resorption in older rats

Cited by 26 publications

References 22 publications

The Effects of Ovariectomy and Naproxen Treatment on the Strength of Femoral Midshaft and Molar Alveolar Region in Rats

The Effects of Ovariectomy and Naproxen Treatment on the Strength of Femoral Midshaft and Molar Alveolar Region in Rats

Pharmacology and potential therapeutic applications of nitric oxide‐releasing non‐steroidal anti‐inflammatory and related nitric oxide‐donating drugs

Extracellular Bone Acidic Glycoprotein-75 Defines Condensed Mesenchyme Regions to be Mineralized and Localizes with Bone Sialoprotein during Intramembranous Bone Formation

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