Flurbiprofen Axetil Enhances Analgesic Effects of Sufentanil and Attenuates Postoperative Emergence Agitation and Systemic Proinflammation in Patients Undergoing Tangential Excision Surgery

Abstract

Objective. Our present study tested whether flurbiprofen axetil could reduce perioperative sufentanil consumption and provide postoperative analgesia with decrease in emergency agitation and systemic proinflammatory cytokines release. Methods. Ninety patients undergoing tangential excision surgery were randomly assigned to three groups: (1) preoperative dose of 100 mg flurbiprofen axetil and a postoperative dose of 2 μg/kg sufentanil and 10 mL placebo by patient-controlled analgesia (PCA) pump, (2) preoperative dose of 100 mg flurbiprofen axetil and a postoperative dose of 2 μg/kg sufentanil and 100 mg flurbiprofen axetil by PCA pump, and (3) 10 mL placebo and a postoperative dose of 2 μg/kg sufentanil and 10 mL placebo by PCA pump. Results. Preoperative administration of flurbiprofen axetil decreased postoperative tramadol consumption and the visual analog scale at 4, 6, 12, and 24 h after surgery, which were further decreased by postoperative administration of flurbiprofen axetil. Furthermore, flurbiprofen axetil attenuated emergency agitation score and Ramsay score at 0, 5, and 10 min after extubation and reduced the TNF-α and interleukin- (IL-) 6 levels at 24 and 48 h after the operation. Conclusion. Flurbiprofen axetil enhances analgesic effects of sufentanil and attenuates emergence agitation and systemic proinflammation in patients undergoing tangential excision surgery.

Comparison of perioperative flurbiprofen axetil or celecoxib administration for pain management after total-knee arthroplasty

“…Though some clinical studies have conflicting results regarding the efficacy of preemptive analgesia, [ 16 ] similar to other studies, [ 7 , 9 ] our present study suggested preoperative administration of FA and CX had preemptive analgesia effects. Researchers argue that almost all the analgesic studies were published by anesthetists, and some important details usually considered by orthopedics, such as surgical approach, technique of incision, and type of implant were not reported in those papers.…”

“…[ 5 – 8 ] Flurbiprofen axetil (FA), which is incorporated in lipid microspheres, is a NSAID with high affinity to the site of surgical incision. [ 9 ] Celecoxib (CX) is a selective cyclooxygenase-2 (COX-2) inhibitor shown to be as effective as traditional NSAIDs as an analgesic for acute postoperative pain and has fewer gastrointestinal side effects than traditional NSAIDs. [ 7 ] There are a few reports compare the effectiveness of preoperative flurbiprofen axetil and celecoxib on postoperative analgesic and perioperative opioid consumption after TKA.…”

Efficacy of perineural dexamethasone with ropivacaine in thoracic paravertebral block for postoperative analgesia in elective thoracotomy: a randomized, double-blind, placebo-controlled trial

“…In addition, sufentanil with flurbiprofen as an alternative multimodal analgesia for postoperative pain control was given as a loading dose for PCA at the end of surgery. Studies have shown that postoperative analgesia with opioid plus flurbiprofen resulted in lower pain scores, 36 , 37 thus, this strategy of multimodal postoperative analgesia was applied in this study. Even though the routine use of PCA with a background infusion is not recommended, it remains suitable in patients after thoracotomy who require high opioid consumption or complain of waking due to severe pain at night.…”

Effect of flurbiprofen axetil on postoperative delirium for elderly patients

“…It was reported that parecoxib sodium, a nonsteroidal anti-inflammatory drug (NSAID) and selective cyclooxygenase (COX)-2 inhibitor commonly used for postoperative analgesia, reduced the incidence of POD in elderly patients (Mu et al, 2006). Flurbiprofen axetil, another potent NSAID and nonselective COX inhibitor, was used for postoperative analgesia and reduced postoperative opioid consumption (Geng et al, 2015). Administration of flurbiprofen axetil was proved to reduce inflammatory responses and induce neuroprotective effects (Wang et al, 2008;Xu, Tan, Chen, Lou, & Chen, 2008).…”