Flupirtine and antihistamines exert synergistic anti-nociceptive effects in mice

Kv7 Channel Activators Flupirtine and ML213 Alleviate Neuropathic Pain Behavior in the Streptozotocin Rat Model of Diabetic Neuropathy

“…For example, flupirtine was found to be effective in attenuating heat hypersensitivity in the partial sciatic nerve ligation model of PNP 36 and to reduce mechanical hypersensitivity in mouse models of visceral and inflammatory pain as well as chemotherapy-induced PNP. 52 Our current findings that flupirtine attenuated mechanical hypersensitivity in the STZ rat model of DPNP are in general agreement with these findings and are consistent with our previous findings that activation of K v 7 channels with retigabine dose dependently attenuated mechanical, but not heat hypersensitivity in STZ rats. 15 However, the present study is, as far as we know, the first to report that flupirtine is effective in alleviating NP behavior in the STZ model of DPNP.…”

Nanomaterial-Based Drug Delivery Systems for Pain Treatment and Relief: From the Delivery of a Single Drug to Co-Delivery of Multiple Therapeutics

“…This study established a model of writhing body pain induced by acetic acid, inflammatory pain induced by carrageenan, and neuropathic pain induced using paclitaxel. Antihistamines play a synergistic analgesic role by activating Kv7/M channels [ 26 ]. CBD and beta-caryophyllene (BCP), the non-psychoactive components of cannabis, have more benign side effects than other cannabis components and can reduce neuropathic and inflammatory pain.…”