Fluphenazine Enanthate in the Maintenance Treatment of Schizophrenia

Severe Depressive Mood Changes Following Slow-release Intramuscular Fluphenazine Injection

“…In the past many chronic schizophrenics who responded to maintenance phenothiazine treatment thwarted efforts to rehabilitate them in the community by neglecting to take their medication orally in the amounts and at the time required. With fluphenazine enanthate many of these patients can now be maintained out of hospital (Bethell et al, 1966;Freeman, 1967). Nevertheless, if injected slow-release drugs are to mean a major advance in psychiatric treatment more attention must be paid to their side-effects as well as to their effects.…”

Fluphenazine Enanthate in Sesame Oil, a Depot Preparation

“…A conceivable reduction of the number of relapses may, hFwever, be achieved by giving the psychotropic drug as a preparation with prolonged effect, e. g. an esterified drug dissolved in oil and administered by intramuscular injection (Bethell et al (1966), Crompton (1967). Convenient for such a preparation are solely drugs with a high therapeutic effect per milligram, as only a limited amount of the drug citn be given by each injection.…”