Fluoxetine Treatment for Obsessive-Compulsive Disorder in Children and Adolescents: A Placebo-Controlled Clinical Trial

Geller, Daniel; Hoog, Sharon L.; Heiligenstein, John H.; Ricardi, R. K.; Tamura, Roy; KLUSZYNSKI, STACY; Jacobson, Jennie G.; TEAM, FLUOXETINE PEDIATRIC OCD STUDY

doi:10.1097/00004583-200107000-00011

Cited by 269 publications

(90 citation statements)

References 21 publications

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“…In a comparison of fluoxetine and phenelzine with placebo, efficacy was shown for fluoxetine but not the MAOI (Jenike et al 1997). Efficacy of fluoxetine could also be shown for the treatment of OCD in children and adolescents in DBPC studies (Geller et al 2001;Liebowitz et al 2002b;Riddle et al 1992) (A). Á Paroxetine was significantly more effective than placebo and of comparable efficacy to clomipramine (Zohar and Judge 1996).…”

Section: Selective Serotonin Reuptake Inhibitors (Ssris)mentioning

confidence: 99%

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

Bandelow

Zohar

Hollander

et al. 2008

The World Journal of Biological Psychiatry

699

410

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In this report, which is an update of a guideline published in 2002 (Bandelow et al. 2002, recommendations for the pharmacological treatment of anxiety disorder, obsessive-compulsive disorder (OCD) and post-traumatic stress disorder (PTSD) are presented. Since the publication of the first version of this guideline, a substantial number of new randomized controlled studies of anxiolytics have been published. In particular, more relapse prevention studies are now available that show sustained efficacy of anxiolytic drugs. The recommendations, developed by the World Federation of Societies of Biological Psychiatry (WFSBP) Task Force for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders, a consensus panel of 30 international experts, are now based on 510 published randomized, placebo-or comparator-controlled clinical studies (RCTs) and 130 open studies and case reports. First-line treatments for these disorders are selective serotonin reuptake inhibitors (SSRIs), serotonin-noradrenaline reuptake inhibitors (SNRIs) and the calcium channel modulator pregabalin. Tricyclic antidepressants (TCAs) are equally effective for some disorders, but many are less well tolerated than the SSRIs/ SNRIs. In treatment-resistant cases, benzodiazepines may be used when the patient does not have a history of substance abuse disorders. Potential treatment options for patients unresponsive to standard treatments are described in this overview. Although these guidelines focus on medications, non-pharmacological were also considered. Cognitive behavioural therapy (CBT) and other variants of behaviour therapy have been sufficiently investigated in controlled studies in patients with anxiety disorders, OCD, and PTSD to support them being recommended either alone or in combination with the above medicines.

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Section: Selective Serotonin Reuptake Inhibitors (Ssris)mentioning

confidence: 99%

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

Bandelow

Zohar

Hollander

et al. 2008

The World Journal of Biological Psychiatry

699

410

View full text Add to dashboard Cite

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“…These trials are of variable quality, but they include several large methodologically sound studies and it seems reasonable to conclude that the SSRIs are both safe and efficacious in the short-term treatment of paediatric OCD ( March et al, 1998;Geller et al, 2001;Riddle et al, 2001). The time taken to respond to treatment varies between the studies and, even though Riddle et al reported significant responses after only 1 week of treatment, most authors suggest titration over 6 to 8 weeks to maximum doses in partial or non-responders.…”

Section: Obsessive-compulsive Disordermentioning

confidence: 99%

Current issues in child and adolescent psychopharmacology. Part 2: Anxiety and obsessive—compulsive disorders, autism, Tourette's and schizophrenia

Coghill¹

2003

Adv. psychiatr. treat

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This paper reviews the evidence base supporting the use of pharmacological treatments for child and adolescent psychiatric disorders. Recent advances in knowledge are highlighted, with some of the controversies. New evidence supports a role for selective serotonin reuptake inhibitors in the treatment of anxiety disorders and obsessive–compulsive disorder. Educational and behavioural approaches remain the mainstay of treatment for children and adolescents with autism, but there is evidence that adjunctive medication may be effective. Atypical antipsychotics have been investigated in the treatment of Tourette syndrome and early-onset schizophrenia. Many questions remain unanswered and further research is needed in all areas of paediatric psychopharmacology.

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“…Change can be examined using a number of sources, such as self-report, reports from significant others, use of performance-based or physiological measures, institutional records, and reports from independent laboratory observations (see Tables 7-10; Figure 2; Kazdin, 2003;Kendall, 1999). Indeed, multiple sources (e.g., parent, child, teacher, clinician, independent observer, physiological measurements) are employed in research examining interventions targeting constructs perceived as difficult to measure using methods other than self-assessments (e.g., childhood anxiety; Kendall, 1994;Barrett et al, 1996Barrett et al, ,2004Geller et al, 2001;Liebowitz et al, 2002;Öst et al, 2001). …”

mentioning

confidence: 99%

Conceptualizing changes in behavior in intervention research: The range of possible changes model.

Reyes

Kazdin

2006

Psychological Review

124

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An international movement has focused on identifying evidence-based interventions: Interventions that were developed to change psychological constructs, and have evidence from controlled studies on their behalf. However, inconsistent findings within individual intervention studies and among multiple studies of the same intervention raise critical problems for interpreting the evidence, and deciding when and whether an intervention is evidence-based. A theoretical and methodological framework (Range of Possible Changes [RPC] Model) is proposed to guide the study of change in intervention research. We recommend that future quantitative reviews of the research literature use the RPC Model to conceptualize, examine, and classify the available evidence for interventions. Further, future research should adopt the RPC Model to both develop theory-driven hypotheses and conduct examinations of the instances in which interventions may or may not change psychological constructs. Keywordsefficacy; effectiveness; range of possible changes; intervention; treatment The terms efficacy or effectiveness denote the study of whether interventions can successfully change specific psychological constructs or behaviors (e.g., Hoagwood, Hibbs, Brent, & Jensen, 1995;Kazdin, 2000;Lambert & Ogles, 2004). 1 An overriding goal of intervention research is to identify evidence-based interventions: Evidence from controlled experiments suggests these interventions change constructs they were developed to change. Researchers have developed classification systems through which a given intervention can be identified as evidence-based, based on prior well-controlled experimental outcome studies examining the intervention (e.g., Lonigan, Elbert, & Johnson, 1998;Nathan & Gorman, 2002;Roth & Fonagy, 2005). Upon scrutiny, the supportive evidence raises Correspondence regarding this manuscript should be addressed to Alan E. Kazdin, Child Study Center, Yale University School of Medicine, 230 S. Frontage Road, New Haven, CT 06520-7900. 1 The intervention literature often distinguishes between the terms efficacy and effectiveness by the setting in which changes in constructs occur. Specifically, efficacy research examines whether an intervention can change psychological constructs under controlled experimental conditions. In contrast, effectiveness research examines whether an intervention can change psychological constructs in more naturalistic settings outside the research laboratory. Despite these differences in settings, both of these research literatures examine the ability of interventions to change multidimensional constructs. Thus, the conceptual and methodological framework we propose generally applies to the study of change in multidimensional constructs in intervention research. At the same time, the evidence we cite in support of our proposed framework is largely gleaned from the efficacy literature, particularly because of its longer history of examination and replication, relative to the effectiveness literature. Thus, it is possible...

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Fluoxetine Treatment for Obsessive-Compulsive Disorder in Children and Adolescents: A Placebo-Controlled Clinical Trial

Cited by 269 publications

References 21 publications

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

World Federation of Societies of Biological Psychiatry (WFSBP) Guidelines for the Pharmacological Treatment of Anxiety, Obsessive-Compulsive and Post-Traumatic Stress Disorders – First Revision

Current issues in child and adolescent psychopharmacology. Part 2: Anxiety and obsessive—compulsive disorders, autism, Tourette's and schizophrenia

Conceptualizing changes in behavior in intervention research: The range of possible changes model.

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