Fluoxetine normalizes the effects of prenatal maternal stress on depression- and anxiety-like behaviors in mouse dams and male offspring

Salari, Ali-Akbar; Fatehi-Gharehlar, L.; Motayagheni, Negar; Homberg, Judith R.

doi:10.1016/j.bbr.2016.05.062

Cited by 89 publications

(62 citation statements)

References 84 publications

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“…Although this is only the first study to report such a finding in humans, the cohort was large (15,729 exposures), the design was rigorous, and the findings echo certain results from the animal literature 42, 43 , but conflicting results are available from animal work as well 44 . Thus, this particular outcome, which otherwise has not been at all well investigated in humans, is one that should be kept in mind for additional large, well-designed prospective trials.…”

Section: Part Iii: Obstetrical Fetal and Developmental Outcomes: Masupporting

confidence: 61%

Recent advances in understanding maternal perinatal mood disorders

2017

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The study of perinatal mental health (mental health during pregnancy and postpartum) is a complex field of study that is of major importance both for the mental and physical health of new mothers and for the neurobehavioral development and long-term functioning of the children they bear. In this review, we cover the most recent additions to this rapidly evolving field. Notable advances include further illumination of the epidemiological patterns and clinical manifestations of perinatal mood disruption; new efficacy data on treatment and prevention; clarifications of the respective contributions of maternal mental illness and psychotropic medication to outcomes of pregnancy, birth, and child development; and updated expert guidelines for screening.

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Section: Part Iii: Obstetrical Fetal and Developmental Outcomes: Masupporting

confidence: 61%

Recent advances in understanding maternal perinatal mood disorders

2017

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“…The detrimental effect of gestational stress on parental care and maternal behavior are also very well investigated [6, 7]. However, a few studies examined the influence of stress during gestation on cognitive performance in mice postpartum [8, 9]. …”

Section: Introductionmentioning

confidence: 99%

Corticosterone response to gestational stress and postpartum memory function in mice

et al. 2017

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Maternal stress is a common adversity during pregnancy. Gestational corticosterone alternations are thought to contribute to the etiology of postpartum behavioral disturbances. However, the impact of stress during pregnancy, in particular noise exposure, on gestational corticosterone fluctuations and spatial cognition in postpartum mice has not been fully understood yet. We hypothesized that noise exposure during pregnancy negatively affects gestational corticosterone levels and postpartum memory function in the dams similar to the physical stressors. Pregnant C57BL/6 mice were randomly assigned to either one of two stress conditions or a control condition. The noise stress (NS) was induced by presenting a loud intermittent 3000 Hz frequency on gestational days (GDs) 12, 14, and 16 for 24 hours, whereas the physical stress (PS) consisted of restraint and exposure to an elevated platform on GDs 12–16. Plasma corticosterone level was collected on GDs 11 and 17, and Morris water task (MWT) was carried out 30 days after parturition. Compared to the control group, the level of corticosterone in the stressed groups was significantly increased on GD17 relative to GD11. Significantly longer swim time and lower swim speed were observed in both stressed groups relative to the control group. Probe time was significantly shorter in the NS group than the other groups. The delta corticosterone level was significantly correlated with the swim time as well as the probe time in the three groups. Given the results, the adverse effects of gestational noise exposure on the hypothalamic pituitary-adrenal (HPA) axis activation and postpartum spatial learning and memory function were as large as/ or a bit stronger than the physical stresses. The findings suggest the significance of conservation against loud noise exposure in daily living, as well as need to further notice to the different aspects of gestational stress in mothers’ behavior like offspring.

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“…Other authors have also reported inconsistent results regarding the effects of this type of early stress (Kjær et al, 2010), or failed to demonstrate changes on PPI modulation (Jensen et al, 2007), or anxiety-/depression-like behaviors (Salari et al, 2016), when using other SSRIs under basal conditions. In addition, our data show that there are differences in PPI and latency values between males and females.…”

Section: Discussionmentioning

confidence: 99%

“…In rodents, PS has been linked to many changes in neurotransmitter systems, neuroendocrine function and the behavior of offspring (Kapoor et al, 2006; Wilson et al, 2013). Indeed, prenatally stressed animals tend to exhibit memory impairment (Kosten et al, 2006; Markham et al, 2010), develop higher emotional reactivity (Abe et al, 2007), higher levels of anxiety and fear (Griffin et al, 2003), and depression-like behaviors in adulthood (Salari et al, 2016). This type of early stress has also been shown to disturb noradrenergic and serotonergic homeostasis (Mastorci et al, 2009) and likely to predispose the offspring to the development of mood-related disorders later on in life.…”

Section: Introductionmentioning

confidence: 99%

“…SERT is a selective serotonin reuptake inhibitor (SSRI) used as the front-line medication for treating PTSD in humans (Davidson et al, 2001; Hien et al, 2015). Similar to other SSRIs (Salari et al, 2016), the ability of SERT to relieve PTSD- anxiety- or depression-like symptoms may depend on when the treatment is administered, its duration, and the sex of the individual. It has been suggested that the prolonged administration of SERT is needed to achieve clinical improvement (Kim et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

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Long-Term Sertraline Intake Reverses the Behavioral Changes Induced by Prenatal Stress in Rats in a Sex-Dependent Way

Pereira-Figueiredo

Castellano

Riolobos

et al. 2017

Front. Behav. Neurosci.

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Early life stress is a major factor underlying the vulnerability to respond to stressful events later in life. The present study attempted to evaluate the role of prenatal stress affecting the development of stress-related disorders and their reversion by postnatal exposure to Sertraline (SERT), a front-line medication for medication for posttraumatic stress disorder (PTSD) in humans. To achieve this, adult male and female prenatally stressed (PS) or unstressed (Controls) offspring rats, following oral chronic treatment with SERT (5 mg/kg/day; from 1 month to 4 months old), or not, were studied prior to and after a traumatic event. First, anxiety-like behavior during the prepulse inhibition (PPI) test, a modulation of the startle reflex, was examined in all animals. Subsequently, the animals were subjected to a session of mild inescapable footshocks (IS; 0.35 mA, 5 s) in a shuttle box that was followed by 4 days of situational reminders in the aversive context. Prior to the footshocks no effects of PS or SERT were shown, and no changes in PPI and the habituation to the shuttle box were found. After them, PS led animals to exhibit behavioral alterations. When compared to the Controls, PS animals of both sexes displayed less rearing activity in the aversive environment. PS males responded less to footshock delivery and, in most of the animals, fear extinction was impaired. Moreover, the early postnatal exposure to SERT lessened the behavioral impact of PS in females, while in males it had no effect. Current results extend previous data from our laboratory, showing that PS heightened vulnerability to stress later on, and that SERT acts differently in males and females.

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Fluoxetine normalizes the effects of prenatal maternal stress on depression- and anxiety-like behaviors in mouse dams and male offspring

Cited by 89 publications

References 84 publications

Recent advances in understanding maternal perinatal mood disorders

Recent advances in understanding maternal perinatal mood disorders

Corticosterone response to gestational stress and postpartum memory function in mice

Long-Term Sertraline Intake Reverses the Behavioral Changes Induced by Prenatal Stress in Rats in a Sex-Dependent Way

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