Fluoxetine and diazepam acutely modulate stress induced-behavior

Giacomini, Ana C.V.V.; Abreu, Murilo S. de; Giacomini, Luídia Varrone; Siebel, Anna Maria; Zimerman, Fernanda F.; Rambo, Cassiano L.; Mocelin, Ricieri; Bonan, Carla Denise; Piato, Ângelo; Barcellos, Leonardo José Gil

doi:10.1016/j.bbr.2015.09.027

Cited by 137 publications

(97 citation statements)

References 60 publications

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“…Fluoxetine blocks the increases in defensive behaviour in the novel tank test that are observed 2 min after chasing stress (Giacomini et al, 2016). However, peak levels of whole-body cortisol are observed 15 min after stress (de Abreu et al, 2014), an effect that is also blocked by fluoxetine.…”

Section: Serotonin and The Aversive Behaviour Network Of Zebrafishmentioning

confidence: 90%

“…In the light/dark test, the preference for a black compartment over a white one, associated with risk assessment behaviours, erratic swimming, thigmotaxis, and freezing is interpreted as defensive behaviour (Maximino et al, 2010b). Moreover, a relationship between stress and behaviour in these tests is established, as both acute (Giacomini et al, 2016) and chronic (Chakravarty et al, 2013;Marcon et al, 2016) stress increases defensive behaviour in these assays, and exposure to the apparatuses induce cortisol levels (Kysil et al, 2017). A causal link between neuroendocrine and behavioural responses to stress has not been ascertained; since these are modulated by monoamines, these neurotransmitters could link both functions.…”

Section: Monoaminergic Innervation In Teleostsmentioning

confidence: 99%

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The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Soares

Maximino

2018

Preprint

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Animal-focused research has been crucial for scientific advancement however, in this matter, rodents are still taking a starring role. Coming out from merely being supportive of evidence found in rodents, the use of fish models has slowly taken a more central role and expanded its overall contributions in areas such as social sciences, evolution, physiology, and recently in translational medical research. In neurosciences, zebrafish has been widely adopted, contributing to our understanding of the genetic control of brain processes, and the effects of pharmacological manipulations. However, discussion continues regarding the paradox of function versus structure, when fish and mammals are compared, and on the potentially evolutionarily conserved nature of behaviour across fish species. From the behavioural stand point we explored aversive/stress and social behaviour in selected fish models, and refer to the extensive contributions of stress and monoaminergic systems. We suggest that, in spite of marked neuroanatomical differences between fish and mammals, stress and sociality are conserved at the behavioural and molecular levels. We also suggest that stress and sociality are mediated by monoamines in predictable and non-trivial ways, and that monoamines could "bridge" the relationship between stress and social behaviour. To reconcile the level of divergence with the level of similarity, we need neuroanatomical, pharmacological, behavioural, and ecological studies conducted in the laboratory and in nature.These areas need to add to each other to enhance our understanding of fish behaviour and ultimately how this all may translate to better model systems for translational studies.

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Section: Serotonin and The Aversive Behaviour Network Of Zebrafishmentioning

confidence: 90%

Section: Monoaminergic Innervation In Teleostsmentioning

confidence: 99%

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Soares

Maximino

2018

Preprint

View full text Add to dashboard Cite

show abstract

“…Fluoxetine blocks the anxiogenic effect of chasing stress in the novel tank test 2 min after stress (Giacomini et al, 2016). However, peak levels of whole-body cortisol are observed 15 min after stress (de Abreu et al, 2014), an effect that is also blocked by fluoxetine.…”

Section: Monoaminergic Innervation In Teleostsmentioning

confidence: 95%

“…Moreover, it is now clear that social interactions are also stressful for fish -especially in the case of mutualistic species, in which every interaction carries the potential for predation. However, stress tends to increase shoaling and decrease social preference (Giacomini et al, 2016). Is it possible that cortisol is the mediator of D2-like effects on cooperation ( Figure 3C The relationship between stress coping and sociality is also of interest here.…”

Section: A Way Forward: Integration Between Stress and Sociality In Fishmentioning

confidence: 98%

“…Moreover, a relationship between stress and behaviour in these tests is established, as both acute (Giacomini et al, 2016) and chronic (Chakravarty et al, 2013;Marcon et al, 2016) stress increases anxiety-like behaviour in these assays, and exposure to the apparatuses induce cortisol levels (Kysil et al, 2017). A causal link between neuroendocrine and behavioural responses to stress has not been ascertained; since these are modulated by monoamines, these upstream modulators could link both functions.…”

Section: Monoaminergic Innervation In Teleostsmentioning

confidence: 99%

See 1 more Smart Citation

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Soares¹,

Maximino²

2018

Preprint

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Animal-focused research has been crucial for scientific advancement however, in this matter, rodents are still taking a starring role. Coming out from merely being supportive of evidence found in rodents, the use of fish models has slowly taken a more central role and expanded its overall contributions in areas such as social sciences, evolution, physiology, and recently in translational medical research. In neurosciences, zebrafish has been widely adopted, contributing to our understanding of the genetic control of brain processes, and the effects of pharmacological manipulations. However, discussion continues regarding the paradox of function versus structure, when fish and mammals are compared, and on the potentially evolutionarily conserved nature of behaviour across fish species. From the behavioural stand point we explorted aversive/stress and social behaviour in selected fish models, and refer to the extensive contributions of stress and monoaminergic systems. We suggest that, in spite of marked neuroanatomical differences between fish and mammals, stress and sociality are conserved at the behavioural and molecular levels. We also suggest that stress and sociality are mediated by monoamines in predictable and non-trivial ways, and that monoamines could “bridge” the relationship between stress and social behaviour. To reconcile the level of divergence with the level of similarity, neuroanatomy, pharmacology, behavioural analysis, and ecology studies conducted in the laboratory and in nature need to add to each other and enhance our understanding of fish behaviour and ultimately how this all may translate to better model systems for translational studies.

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Antipredator phenotype in crucian carp altered by a psychoactive drug

Vinterstare

Brönmark

Nilsson

et al. 2021

Ecology and Evolution

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Antipredator defenses can be constitutive, that is, always expressed by the host regardless of the prevailing risk of predation. Many prey organisms however confront intermittent and unpredictable predation risk, which may instead favor phenotypically plastic defense traits, that is, the ability to express adaptive phenotypes according to prevailing risk of predation (DeWitt & Scheiner, 2004). In spite of recent progress in our theoretical and empirical understanding of the ecology and evolution of phenotypic plasticity in antipredator traits (e.g.,

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Fluoxetine and diazepam acutely modulate stress induced-behavior

Cited by 137 publications

References 60 publications

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

The Integration of Sociality, Monoamines, and Stress Neuroendocrinology in Fish Models: Applications in the Neurosciences

Antipredator phenotype in crucian carp altered by a psychoactive drug

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