Fluoxetine and amitriptyline in elderly depressed patients. A 10-week, double-blind study on course of neurocognitive adverse events and depressive symptoms

Comparative Efficacy and Safety of Selective Serotonin Reuptake Inhibitors and Serotonin‐Norepinephrine Reuptake Inhibitors in Older Adults: A Network Meta‐Analysis

“…Five hundred thirty‐four abstracts were identified in the systematic literature search, of which 114 full‐text articles were deemed potentially eligible after scanning all abstracts; 15 of these were deemed eligible for inclusion in the study, and 12 of these studies reported on partial response, 12 on dizziness, three on falls, and two on syncope . (Studies with zero‐zero events were excluded from this count.)…”

“…Direct evidence was consistent with indirect evidence for these outcomes. The included trials assessed seven SSRIs and SNRIs: sertraline, venlafaxine, citalopram, paroxetine, duloxetine, fluoxetine, and escitalopram . Six trials comparing any of these seven interventions with trazodone or with amitriptyline or trazodone and amitriptyline with each other were also included to strengthen the network evidence.…”

Efficacy of treatment in older depressed patients: A systematic review and meta-analysis of double-blind randomized controlled trials with antidepressants

“…All 19 RCTs that did not produce extractable response data found no differences between classes of antidepressants (Altamura et al, 1989a(Altamura et al, ,1989bAther et al, 1985;Biziere and Berger, 1990;Bloeink et al, 1985;De Ronchi et al, 1998;De Vanna et al, 1990;Dunner et al, 1992;Eklund et al, 1985;Feighner et al, 1988;Katona et al, 1999; La Pia , 1992;Mulsant et al, 2001;Pancheri et al, 1994;Pelicier and Schaeffer, 1993;Phanjoo et al, 1991;Rosenberg et al, 2007;Siegfried and O'Connolly, 1986;Smeraldi et al, 1998).…”

Antidepressants and Body Weight

“…An initial weight loss, common to many ◆ antidepressants, is very frequently followed by weight gain. 49 11 MD -Maggioni et al, 2005 50 29 Headache -Chouinard, 1985 51 29 MD + Hecht Orzack et al, 1986 52,b 90 MD + Harris et al, 1986 53 14 MD -Fernstrom and Kupfer, 1988 54 18 MD + Altamura et al, 1989 55 10 MD -Cohn et al, 1990 56 71 MD + Reimherr et al, 1990 57,b 139 MD + Bakish et al, 1992 58,b 52 MD + Beasley et al, 1993 59 71 MD + De Ronchi et al, 1998 60 33 MD -Sacchetti et al, 2002 61 29 MD + Berilgen et al, 2005 62 19 Migraine -Altintoprak et al, 2008 63 20 MD -Imipramine Bremner, 1984 64 20 MD + Frank et al, 1990 65 128 MD + Cohn et al, 1990 56 144 MD + Frank et al, 1992 66 115 MD + Reimherr et al, 1990 57,b 136 MD + Mavissakalian and Perel, 1992 67 19 Anxiety + Balon et al, 1993 68,b 14 PD + Mavissakalian and Perel, 2000 69 66 Anxiety + Shioiri et al, 1993 70 46 MD -Mavissakalian et al, 2002 71 20 Anxiety + Fabre et al, 1995 72,b 212 MD + Mavissakalian, 2003 73 20 Anxiety -Mavissakalian and Perel, 2000 69 77 PD + Silverstone, 2001 74 75 MD -Moosa et al, 2003 75 77 MD + Mavissakalian, 2003 73 20 PD -Clomipramine Beaumont, 1977 76 61 MD -Maina et al, 2004 77 23 Anxiety + Guelfi et al, 1992 78 56 MD -Shioiri et al, 1993 70 31 MD -Nortriptyline Fernstrom and Kupfer, 1988 54 18 MD + Miller et al, 1991 79 30 MD + Weber et al, 2000 80 12 MD + Paradis et al, 1992 …”