Fluosol a special boon to Jehovah's Witnesses..

Er, González

doi:10.1001/jama.243.8.720

Cited by 5 publications

(3 citation statements)

References 0 publications

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“…PFCs are surrounded by a lecithin surfactant in a water-based solution. The first approved O 2carrying blood substitute was a perfluorocarbon called Fluosol [14]. It was approved by the FDA in 1989 but withdrawn in 1994 due to adverse effects.…”

Section: Discussionmentioning

confidence: 99%

Treating a Patient with Your Hands Tied: Acute Chest Syndrome in a Jehovah’s Witness

Vadehra

Davino

Datta

2020

Cureus

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Acute chest syndrome (ACS), a vaso-occlusive crisis in patients with sickle cell anemia, is a lifethreatening condition and a leading cause of death in these patients. It is treated with analgesics, antibiotics, intravenous fluid, supplemental oxygen (or ventilatory support in severe cases) with simple or exchange transfusion, being the mainstay of therapy. We report a young Jehovah's Witness (JW) patient with sickle cell anemia who presented with ACS. Her religious beliefs precluded the use of blood products. Despite concomitant hemolytic and aplastic crisis and a hemoglobin nadir of 3.1 g/dL, the patient was treated successfully with supportive care-including mechanical ventilation, sedation, paralysis, and erythropoiesis stimulation-and survived. A maximal supportive strategy consisting of ventilatory support with a high fraction of inspired oxygen, sedation, paralysis, erythropoiesis stimulation, and limitation of blood draws can result in the successful treatment of JW patients who refuse blood products.

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Section: Discussionmentioning

confidence: 99%

Treating a Patient with Your Hands Tied: Acute Chest Syndrome in a Jehovah’s Witness

Vadehra

Davino

Datta

2020

Cureus

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“…PFC emulsions have been of interest to physiologists for a number of years as oxygen-carrying media and supplements for blood and certain blood products [8]. As a class of compounds, PFCs act as simple oxygen solvents, with a solubility for O2 that is several times greater than that of plasma [13] need to test for potential pathogens (e.g., syphilis, hepatitis B, cytomegalo virus, acquired immune deficiency syndrome), and eventually, (3) lower cost.…”

Section: Discussionmentioning

confidence: 99%

“…As a class of compounds, PFCs act as simple oxygen solvents, with a solubility for O2 that is several times greater than that of plasma [13] need to test for potential pathogens (e.g., syphilis, hepatitis B, cytomegalo virus, acquired immune deficiency syndrome), and eventually, (3) lower cost. PFC emulsions may also be used as emergency substitutes for blood in patients such as Jehovah's Witnesses, who have religious objections to the transfusion of natural blood products [8].…”

Section: Discussionmentioning

confidence: 99%

Massive Transfusion of Perfluorocarbon Emulsion (Fluosol-DA) in Newborn Piglets

Hall¹,

Karlson²,

DuRant³

1987

Dev Pharmacol Ther

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To study massive perfluorocarbon transfusion in neonatal animals, 30 piglets (less than 24 h old) were randomly assigned to 3 groups: (1) Fluosol-DA-treated (50 ml/kg), (2) albumin-treated (50 ml/kg), and (3) non-treated controls. Pre- and post-transfusion measurements included blood chemistries and complete blood count (CBC). Posttransfusion histological analysis of tissues was also performed. There was no mortality or respiratory distress in the piglets that received Fluosol transfusion. Fluosol-treated piglets had significantly lower (p < 0.05) post-transfusion serum calcium and serum glutamic oxaloacetic transaminase values than the controls. The Fluosol group also had significantly higher chloride and glucose, but lower calcium and bilirubin levels than the albumin group. However, in no cases were the differences of clinical significance. There were no differences between the experimental groups’ pre- and post-transfusion CBC values. Microscopic examination of lung, heart, and spleen samples revealed only the presence of splenic vacuoles which we attributed to perfluorocarbon accumulation.

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Surgery in Jehovah’s Witnesses

Wong

Jenkins

1989

Can J Anaesth

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Fluosol a special boon to Jehovah's Witnesses..

Cited by 5 publications

References 0 publications

Treating a Patient with Your Hands Tied: Acute Chest Syndrome in a Jehovah’s Witness

Treating a Patient with Your Hands Tied: Acute Chest Syndrome in a Jehovah’s Witness

Massive Transfusion of Perfluorocarbon Emulsion (Fluosol-DA) in Newborn Piglets

Surgery in Jehovah’s Witnesses

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