Fluorous Synthesis

Zhang, Wei

doi:10.1002/9780470711828.ch16

Cited by 6 publications

(2 citation statements)

References 86 publications

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“…In this context, strategic and tactical outsourcing has been utilized to leverage internal and external capacities, while improving overall efficiencies and economics by externally procuring key raw materials, intermediates, and even the final APIs. Furthermore, deliberate incorporation of niche suppliers utilizing specialized technologies such as biocatalysis, flow chemistry, and pressure reactions can lead to environmental and economic advantages …”

Section: Introductionmentioning

confidence: 99%

The Eight Criteria Defining a Good Chemical Manufacturing Process

Dach

Song

Roschangar

et al. 2012

Org. Process Res. Dev.

116

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As pharmaceutical API projects advance from Development to Chemical Production, the primary objective of the Process Research and Development (R&D) chemists is a smooth transfer of a well-developed, safe, scalable, robust, and economical chemical process to their customers in Chemical Production. Since the definition of a Good Chemical Manufacturing Process differs widely amongst different departments and companies, we herein summarize eight useful process evaluation criteria, and then demonstrate our deployment according to the guiding principle “if it can be measured, then it can also be managed”, with the aim to offer chemists a helpful toolbox to effectively compare competing API synthesis routes.

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Section: Introductionmentioning

confidence: 99%

The Eight Criteria Defining a Good Chemical Manufacturing Process

Dach

Song

Roschangar

et al. 2012

Org. Process Res. Dev.

116

View full text Add to dashboard Cite

show abstract

“…In simple terms, green chemistry is the design of products or processes that minimize or eliminate the use, generation, or disposal of hazardous chemical substances (Anastas and Warner, 1998; Horváth and Anastas, 2007; Li and Trost, 2008; Sheldon, 2012; Zhang and Cur Jr., 2012). Achieving this goal may include design of better synthetic pathways, use of alternative reaction conditions, and/or invention of safer (non-toxic) chemicals.…”

Section: Introductionmentioning

confidence: 99%

Ethanolic carbon-11 chemistry: The introduction of green radiochemistry

Shao

Fawaz

Jang

et al. 2014

Applied Radiation and Isotopes

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The principles of green chemistry have been applied to a radiochemistry setting. Eleven carbon-11 labeled radiopharmaceuticals have been prepared using ethanol as the only organic solvent throughout the entire manufacturing process. The removal of all other organic solvents from the process simplifies production and quality control (QC) testing, moving our PET Center towards the first example of a green radiochemistry laboratory. All radiopharmaceutical doses prepared are suitable for clinical use.

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ChemInform Abstract: Fluorous Synthesis

Zhang¹

2013

ChemInform

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Fluorous Synthesis

Cited by 6 publications

References 86 publications

The Eight Criteria Defining a Good Chemical Manufacturing Process

The Eight Criteria Defining a Good Chemical Manufacturing Process

Ethanolic carbon-11 chemistry: The introduction of green radiochemistry

ChemInform Abstract: Fluorous Synthesis

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