Fluorosulfanilanilides

Identification of a class of sulfonamides highly active against dihydropteroate synthase form Toxoplasma gondii, Pneumocystis carinii, and Mycobacterium avium

“…The compounds from the National Cancer Institute repository were selected from a large pool of compounds by utilizing computerized substructure searching (16) based upon potential relevance, interest reflected in the literature, and existing active leads. Compounds 1507 and 1508 were synthesized by a previously published method (10). All reference numbers for the compounds refer to National Cancer Institute entry numbers.…”