Purpose Balloon kyphoplasty is currently widely used for the treatment of vertebral compression fractures (VCFs). Procedure safety is directly linked to precise radiological imaging generated by various X-ray systems (C-arm, O-arm Ò , angiography table, etc.). This minimally invasive spinal surgery is, by definition, associated with significant radiation exposure for both patient and surgeon. Real dose exposure received by the surgeon is usually difficult to precisely record. In our center, all Balloon Kyphoplasty Procedures (BKP) are now performed using an O-arm Ò image guidance system to control cement augmentation in VCF. Our preliminary experience described reduced dose exposure compared to C-arm guided procedures. We present here an additional way to considerably reduce the amount of radiation received by the surgeon during BKP using a new injection system. Methods We prospectively evaluated O-arm Ò guided BKP in 20 consecutive patients alternatively allocated to either classic O-arm Ò BKP with direct bone filler injection or BKP using a new Cement Delivery System (CDS). Eye, wrist, finger and leg measurements were taken bilaterally and compared between the two groups.Results The radiation dose received by the surgeon's finger, wrist and leg was reduced by greater than 80 % when using the CDS. It allows the surgeon to work way below the most severe annual limit of dose exposure, which may not be the case when using a classical bone filler direct injection mechanism. Conclusion We believe that when using this new intraoperative injection system, the surgeon's overall anatomic exposure is significantly reduced without compromising the critical procedure steps.Keywords Balloon kyphoplasty Á Vertebral compression fractures Á Radiation exposure Á Minimal invasive spinal surgery Á Cement delivery system Purpose As the population continues to age, the challenge for treating vertebral compression fractures (VCFs) due to osteoporosis, trauma, metastases and myeloma, and their respective complications will become increasingly prevalent. VCF mainly due to osteoporosis represents today a major concern amongst elderly patients, frequently leading to pain, disability and deterioration of quality of life. Every year worldwide an estimated 1.4 million VCFs cause pain and suffering [1][2][3]. Annually, there are an estimated 700,000 osteoporotic VCFs in the United States [4,5]. Approximately, 26 % of women over the age of 50 and 40 % of women over 80 years of age are reported to have sustained a VCF [4,6].At present, conservative non-surgical treatment of VCFs with drugs, surgical braces and rehabilitation still has shortcomings. Recently, the development of minimal invasive surgery (MIS), such as balloon kyphoplasty, has Electronic supplementary material The online version of this article