Fluoroquinolones and the Risk of Achilles Tendon Disorders: Update on a Neglected Complication

Godoy‐Santos, Alexandre Leme; Bruschini, Homero; Cury, José; Srougi, Miguel; Fonseca, Lucas Furtado da; Maffulli, Nicola

doi:10.1016/j.urology.2017.10.017

Cited by 31 publications

(37 citation statements)

References 45 publications

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“…In adult populations, several risk factors for FQ-associated tendinopathy such as increased age, the male gender, glucocorticoid use, diabetes, and renal failure have been reported 18–22 . The male gender and increased age were associated with an elevated risk in pediatric patients, which agrees with findings from previous studies involving adults 19,20 . However, steroid use, diabetes, and renal disease did not significantly affect the incidence of musculoskeletal AEs after matching and adjustments.…”

Section: Discussionsupporting

confidence: 91%

Real-world safety evaluation of musculoskeletal adverse events associated with Korean pediatric fluoroquinolone use: a nationwide longitudinal retrospective cohort study

Kim

Paik

Khan

et al. 2019

Sci Rep

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Though the pediatric use of fluoroquinolones (FQs) is limited for musculoskeletal safety concerns, the clinical usefulness still exists. This study examined the association between FQs and musculoskeletal adverse events (AEs) as well as the possible risk factors associated with the pediatric FQs uses. This population-based, longitudinal, retrospective study was conducted using Korean National Sample Cohort database originating between 2002 and 2015. An FQ-treated pediatric cohort (<18 years old) was compared to a control treated with amoxicillin. Propensity score matching (PSM) and a Cox proportional hazard model was used to estimate the hazard ratio (HR) for a diagnosis of musculoskeletal AEs within 60 days of the first prescription. Among one million participants, total of 15,706 and 147,840 children were eligible for the FQ and amoxicillin cohorts, respectively. The PSM cohorts showed a slightly increased risk of musculoskeletal AEs after FQ treatment (HR, 1.19; 95% confidence interval, 1.01–1.40; p = 0.042). This association was stronger in males, older patients, and some FQs users. This study indicates that pediatric FQ use is associated with a risk of musculoskeletal AEs and that FQ use should be carefully monitored in groups with certain risk factors. Well-designed pragmatic trials could be expected to clarify these issues.

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Section: Discussionsupporting

confidence: 91%

Real-world safety evaluation of musculoskeletal adverse events associated with Korean pediatric fluoroquinolone use: a nationwide longitudinal retrospective cohort study

Kim

Paik

Khan

et al. 2019

Sci Rep

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“…The widespread prophylactic use of ciprofloxacin during the period following the anthrax mailing attacks is illustrative of an understudied area. Ciprofloxacin has been increasingly associated with tendonitis and ruptured Achilles tendons (Akali and Niranjan, 2008;Palin and Gough, 2006;Godoy-Santos et al, 2018). In the future, better methodology to follow the pharmacokinetics of an antiinfective compound may have forensic implications.…”

Section: Possible Scenarios Of Bioterrorism Attacks: Distinguishing Vmentioning

confidence: 99%

The use of host factors in microbial forensics

Schutzer

2020

Microbial Forensics

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“…Medications associated with tendon disorders are corticosteroids, quinolone antibiotics,60 aromatase inhibitors (oestrogen inhibitors) and statins.…”

Section: Aetiologymentioning

confidence: 99%