Fluoroquinolone resistance in Campylobacter jejuni and Campylobacter coli isolated from human faeces in Switzerland

Adler-Mosca, H.; Altwegg, Martin

doi:10.1016/0163-4453(91)93440-n

Cited by 7 publications

(2 citation statements)

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“…The determination of MICs allows comparison of results from different studies, even if the applied breakpoints are different from one study to another in relation to the lack of specific recommendations for campylobacters by the NCCLS [32]. In the present study, 15% of C. jejuni were found to be resistant to fluoroquinolones, a rate higher than the 3% of quinolone resistance reported in Switzerland in 1990 by Adler‐Mosca and Altwegg [7], but lower than those reported elsewhere. In Spain, up to 50% of campylobacters were resistant to fluoroquinolones [14], and in Thailand an explosive increase was noted, with 84% of campylobacters found to be resistant to fluoroquinolones and 15% to macrolides [9].…”

Section: Discussionmentioning

confidence: 46%

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Species identification and antimicrobial susceptibility of Campylobacter spp. and related organisms: a 2-year survey in a tertiary university hospital

Liassine

Burnens

Fournier

et al. 1999

Clinical Microbiology and Infection

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Objective: To identify at species level, in a prospective study in a tertiary university hospital during the two years 1996 and 1997, all isolates of Campylobacferspp. and related organisms and to determine their susceptibility to erythromycin and ciprofloxacin. Methods:The feces were collected in Caw-Blair medium, and isolation was performed on Karmali agar incubated at 35°C. BACTEC Plus aerobic/f vials were used for blood cultures. Identification was performed by biochemical methods for Campylobacter jejuni and by molecular hybridization for the other species. MlCs for erythromycin and ciprofloxacin were determined by Etest. Result.:In total, 142 isolates from 140 infected patients, including 135 fecal isolates and seven blood isolates, were analyzed. Clinical findings of the seven patients with bacteremia and the seven patients with gastroenteritis due to species other than Campylobacfer jejuni or Campylobacter coli showed a predominance of immunocompromised patients. The fecal isolates include 113 (83.7%) Campylobacfer jejuni, nine (6.6%) Campylobacter coli, four Arcobacter butzleri, two Campylobacter fetus and one Helicobacter pullorum. Of the seven isolates from blood culture. three were Campylobacter jejuni, three Campylobacter fetus and one Helicobacter cinaedi. Resistance to ciprofloxacin (MIC >4 mgk) was reported for 18 (1 5.6%) Campylobacfer jejuni isolates, three Campylobacfer coli isolates, one Campylobacter fetus isolate and one Arcobacfer bufzleri isolate. Resistance to erythromycin (MIC >8 mgL) was found for two isolates of Campylobacter coli, which were also resistant to ciprofloxacin, and the isolate of Helicobacter cinaedi.Conclusions: This study reports a predominance of Campylobacfer jejuni from stools, but a variety of more rarely isolated species was found in immunocompromised patients, emphasizing the necessity to identify fecal as well as blood isolates to the species level. Antimicrobial susceptibility tests to major antibiotics active against campylobacteria should be done routinely to follow the rate of resistance.

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Section: Discussionmentioning

confidence: 46%

“…Fluoroquinolones are often given empirically to treat suspected gastroenteritis because they are active against all of the main enteric pathogens. In recent years, the emergence and spread of resistance in campylobacters, mainly to fluoroquinolones [7–12] but also to macrolides [9, 11, 13–15], has been reported in different countries.…”

Section: Introductionmentioning

confidence: 99%