“…In 1970, Akitane was appointed as an associate professor in the Department of Pathological Neurochemistry, Institute of Molecular and Cellar Medicine, Okayama University Medical School, and then, in 1972, became professor and chairman of the Department of Neurochemistry, where he remained until he retired in 1995. Akitane continued his guanidino compound research there in Okayama, and developed distinctive analytical methods for guanidino compounds using automated liquid chromatography [10,11], fluorometry [12,13], or gas chromatography-mass spectrometry [14], and observed the above mentioned guanidino compounds. These analyses were used to elucidate the seizure mechanisms of these compounds as will be discussed in more detail in the following section [9,[15][16][17][18].…”