Fluorodeoxyglucose PET imaging in the evaluation of gallbladder carcinoma and cholangiocarcinoma

Anderson, Christopher; Rice, Michael H.; Pinson, C. Wright; Chapman, William C.; Chari, Ravi S.; Delbeke, Dominique

doi:10.1016/j.gassur.2003.10.003

Cited by 332 publications

(245 citation statements)

References 15 publications

Supporting

Mentioning

226

Contrasting

Unclassified

Order By: Relevance

“…84,85 The altered metabolic state in the brain regions examined during depression and antidepressant treatments has been demonstrated by 18-fluorodeoxyglucose PET studies. 86,87 GPD3 was found to be transcriptionally regulated in relation to changes in neuronal activity and antidepressant drug treatment. 88 Enhanced expression of GPD3 might reflect increased metabolic requirements and contribute to a higher Na/K ATPase activity that can accelerate the rate of neuronal repolarization.…”

Section: Number Of Transcripts Affected By Single and Multiple Treatmmentioning

confidence: 99%

Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine

et al. 2006

View full text Add to dashboard Cite

The significant proportion of depressed patients that are resistant to monoaminergic drug therapy and the slow onset of therapeutic effects of the selective serotonin reuptake inhibitors (SSRIs)/serotonin/noradrenaline reuptake inhibitors (SNRIs) are two major reasons for the sustained search for new antidepressants. In an attempt to identify common underlying mechanisms for fast-and slow-acting antidepressant modalities, we have examined the transcriptional changes in seven different brain regions of the rat brain induced by three clinically effective antidepressant treatments: electro convulsive therapy (ECT), sleep deprivation (SD), and fluoxetine (FLX), the most commonly used slow-onset antidepressant. Each of these antidepressant treatments was applied with the same regimen known to have clinical efficacy: 2 days of ECT (four sessions per day), 24 h of SD, and 14 days of daily treatment of FLX, respectively. Transcriptional changes were evaluated on RNA extracted from seven different brain regions using the Affymetrix rat genome microarray 230 2.0. The gene chip data were validated using in situ hybridization or autoradiography for selected genes. The major findings of the study are:1. The transcriptional changes induced by SD, ECT and SSRI display a regionally specific distribution distinct to each treatment. 2. The fast-onset, short-lived antidepressant treatments ECT and SD evoked transcriptional changes primarily in the catecholaminergic system, whereas the slow-onset antidepressant FLX treatment evoked transcriptional changes in the serotonergic system. 3. ECT and SD affect in a similar manner the same brain regions, primarily the locus coeruleus, whereas the effects of FLX were primarily in the dorsal raphe and hypothalamus, suggesting that both different regions and pathways account for fast onset but short lasting effects as compared to slow-onset but long-lasting effects. However, the similarity between effects of ECT and SD is somewhat confounded by the fact that the two treatments appear to regulate a number of transcripts in an opposite manner. 4. Multiple transcripts (e.g. brain-derived neurotrophic factor (BDNF), serum/glucocorticoidregulated kinase (Sgk1)), whose level was reported to be affected by antidepressants or behavioral manipulations, were also found to be regulated by the treatments used in the present study. Several novel findings of transcriptional regulation upon one, two or all three treatments were made, for the latter we highlight homer, erg2, HSP27, the proto oncogene ret, sulfotransferase family 1A (Sult1a1), glycerol 3-phosphate dehydrogenase (GPD3), the orphan receptor G protein-coupled receptor 88 (GPR88) and a large number of expressed sequence tags (ESTs). 5. Transcripts encoding proteins involved in synaptic plasticity in the hippocampus were strongly affected by ECT and SD, but not by FLX.The novel transcripts, concomitantly regulated by several antidepressant treatments, may represent novel targets for fast onset, long-duration antidepressants.

show abstract

Section: Number Of Transcripts Affected By Single and Multiple Treatmmentioning

confidence: 99%

Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine

et al. 2006

View full text Add to dashboard Cite

show abstract

“…A larger retrospective study on the same topic, published in 2004 [19], included 50 patients with suspected lesions of the biliary tract (36 patients with suspected ICC and 14 patients with suspected gallbladder carcinoma). The ICC patients were divided into two groups on the basis of tumor size (maximum diameter of 1 cm vs. infiltrating mass).…”

Section: Fdg In Intrahepatic Cholangiocarcinomamentioning

confidence: 99%

FDG and other radiopharmaceuticals in the evaluation of liver lesions

Grassi

Morigi

Nanni

et al. 2014

Clin Transl Imaging

View full text Add to dashboard Cite

Liver nodules are common findings in medical practice, both in patients with and in those without chronic liver disease. These lesions have to be interpreted according to clinical history and biochemical findings. Conventional imaging (US, CT and MRI) is still the gold standard for evaluating liver nodules, while diagnostic flowcharts do not currently include PET/CT. Since the 1990s many studies have been conducted to assess a possible role for FDG PET or PET/ CT in several liver pathologies. According to the literature, FDG PET (and later PET/CT) could be useful in detecting, staging and grading hepatocellular carcinoma, often leading to a change in therapy, and may even detect intrahepatic cholangiocarcinoma with adequate sensitivity. Moreover, FDG can allow more accurate staging of hepatic involvement deriving from other tumors (often underestimated by conventional imaging) and, therefore, more appropriate therapy in affected patients. Finally, FDG PET can also be used to evaluate 90 Y microsphere therapy response. Other conditions (e.g., primary hepatic lymphoma when conventional imaging is inconclusive) may benefit from the use of FDG PET/CT, while benign lesions (e.g., focal nodular hyperplasia) show low FDG avidity. As regards non-FDG tracers, choline and acetate (ACE) have been evaluated in comparison with FDG and found to show good efficacy in detecting and staging wellor moderately differentiated HCC. However, their sensitivity in poorly differentiated HCC is very low, suggesting that dualtracer investigation (FDG and choline/FDG and ACE) could be useful when non-invasive grading is required. Despite promising results, PET evaluation of liver nodules still seems to be far from routine application, mostly because of costrelated issues.

show abstract

“…The utility of 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET scan) in the diagnosis and staging of HCCA is uncertain. Anderson et al [37] showed that PET can accurately detect nodular cholangiocarcinomas as small as 1 cm with a sensitivity of 85%. However, infiltrating tumors which are more frequent are only detected in 18% of the cases.…”

Section: Distant Extension Of Cholangiocarcinoma: Distant Stagingmentioning

confidence: 99%

Radiological diagnosis and staging of hilar cholangiocarcinoma

Valls

Ruíz²,

Martínez³

et al. 2013

WJGO

View full text Add to dashboard Cite

Core tip: Hilar cholangiocarcinoma is a rare malignant tumor arising from the epithelium of the bile ducts. Surgery is still the only chance of potentially curative treatment in patients with perihilar cholangiocarcinoma. Multidetector computed tomography, magnetic resonance imaging and magnetic resonance cholangiography are useful tools, both to diagnose and stage hilar cholangiocarcinoma. INTRODUCTIONCarcinomas of the extrahepatic biliary tree, commonly known as hilar cholangiocarcinoma (HCCA), Klatskin tumors or perihilar cholangiocarcinomas, are rare malignancies that account for up to 3% of all gastrointestinal cancers. With an incidence rate of 0.5-2.0 cases per 100000, it is estimated that there are between 2500 and 4000 new cases per year in the United States [1] .Although this tumor may potentially affect any location of the biliary tree, tumors involving the biliary confluence, left-hand drive (LHD) and right-hand drive (RHD) (true Klatskin tumors) are most common and account for 40%-60% of all cases. Around 2/3 of cholangiocarcinomas are hilar or extrahepatic and originate from the bile duct epithelium at the level of confluence AbstractHilar cholangiocarcinoma is a rare malignant tumor arising from the epithelium of the bile ducts. Surgery is still the only chance of potentially curative treatment in patients with perihilar cholangiocarcinoma. However, radical resection requires aggressive surgical strategies that should be tailored optimally according to the location, size and vascular invasion of the tumors. Accurate diagnosis and staging of these tumors is therefore critical for optimal treatment planning and for determining a prognosis. Multidetector computed tomography (MDCT), magnetic resonance imaging (MRI) and MR cholangiography are useful tools, both to diagnose and stage hilar cholangiocarcinoma. Modern imaging techniques allow accurate detection of the level of obstruction and the longitudinal and radial spread of the tumor. In addition, high-resolution MDCT and MR provide specific radiographic features to determine vascular involvement of anatomic structures, such as the hepatic artery or the portal vein, which are critical to decide the surgical strategy. Finally, radiological staging allows detection of patients with distant metastasis in the liver or peritoneum who will not benefit from a surgical approach.

show abstract

Fluorodeoxyglucose PET imaging in the evaluation of gallbladder carcinoma and cholangiocarcinoma

Cited by 332 publications

References 15 publications

Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine

Region-specific transcriptional changes following the three antidepressant treatments electro convulsive therapy, sleep deprivation and fluoxetine

FDG and other radiopharmaceuticals in the evaluation of liver lesions

Radiological diagnosis and staging of hilar cholangiocarcinoma

Contact Info

Product

Resources

About