Fluorocarbon emulsions—Designing an efficient shuttle service for the respiratory gases—The so-called ‘Blood Substitutes’

Riess, Jean G.

doi:10.1016/b978-008043405-6/50034-7

Cited by 10 publications

(3 citation statements)

References 139 publications

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“…The PFCs most frequently used for medical purposes are collected in Table 2 and some of their physical characteristics provided in Tables 3 and 4. Eventually, only a very small number of PFCs were found eligible for intravascular O 2 delivery [1,2,37,38].…”

Section: Selecting the Perfluorocarbonmentioning

confidence: 99%

Therapeutic oxygen delivery by perfluorocarbon-based colloids

Krafft

Riess²

2021

Advances in Colloid and Interface Science

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Section: Selecting the Perfluorocarbonmentioning

confidence: 99%

Therapeutic oxygen delivery by perfluorocarbon-based colloids

Krafft

Riess²

2021

Advances in Colloid and Interface Science

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“…They are formed from hydrocarbon analogs by replacing the hydrogen atoms with fluorine atoms. Because PFCs are virtually insoluble in water, they must be formulated into emulsions for intravenous administration 10,11 . Unlike hemoglobin, PFCs do not bind oxygen covalently; instead they simply dissolve oxygen (Henry's Law).…”

Section: Introductionmentioning

confidence: 99%

“…They release the dissolved oxygen in the tissues more readily than hemoglobin because of the weak PFC–oxygen binding forces. Given the particulate nature of the emulsion, it is cleared from the circulation by the reticulo‐endothelial system and eventually excreted from the body as vapor in expired air 10,11 …”

Section: Introductionmentioning

confidence: 99%

Perflubron emulsion increases subcutaneous tissue oxygen tension in rats

Rosen

Hopf

Hunt

2006

Wound Repair Regeneration

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Oxygen plays a central role in wound healing. The hypothesis of this study was that the administration of a perfluorocarbon emulsion, which dissolves oxygen will increase subcutaneous tissue oxygen tension (PsqO2) in normovolemic and hemorrhaged animals. In the first set of experiments, PsqO2 was measured with a polarographic oxygen electrode along the dorsum of normovolemic-anesthetized rats (n=20) breathing supplemental oxygen. After baseline equilibration of tissue oxygen tension, perflubron emulsion (n=12) or saline control (n=8) was administered. Perflubron administration increased PsqO2 by 32.0 +/- 7.2 mmHg, whereas saline administration had no effect (-1.0 +/- 6.6 mmHg). In a second set of experiments, PsqO2 (n=12) was measured in rats breathing 100 percent oxygen after being bled 20 percent of their blood volume. Creating hypovolemic rats allowed for the study of the effect of perflubron emulsion administration on subcutaneous oxygen tension in tissues with compromised blood flow. Perflubron emulsion was only effective at increasing oxygen tension in tissues with oxygen extractions less then 2.0 vol%. These findings agree with those results analytically predicted based on the oxygen solubility of the perflubron emulsion.

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Perfluorinated Nonaromatic Heterocycles

Петров

2009

Fluorinated Heterocyclic Compounds

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Fluorocarbon emulsions—Designing an efficient shuttle service for the respiratory gases—The so-called ‘Blood Substitutes’

Cited by 10 publications

References 139 publications

Therapeutic oxygen delivery by perfluorocarbon-based colloids

Therapeutic oxygen delivery by perfluorocarbon-based colloids

Perflubron emulsion increases subcutaneous tissue oxygen tension in rats

Perfluorinated Nonaromatic Heterocycles

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