Fluoroarenes

Okazoe, Takashi; Ishibashi, Yuichiro

doi:10.1002/9783527827992.ch56

Cited by 1 publication

(1 citation statement)

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“…In addition, numerous fluoroarenes are commercially available. For an overview of fluoroarene synthesis and applications in pharmaceuticals, agrochemicals, and liquid crystals, see ref 44. Reflecting this, an increasing number of applications of fluoroaryl-containing compounds encourages the development of new strategies to synthesize the required building blocks with maximum efficiency and minimum cost, and, in recent years, significant developments have been made to access these valuable intermediates.…”

Section: Introductionmentioning

confidence: 99%

Applications of Transition Metal-Catalyzed ortho-Fluorine-Directed C–H Functionalization of (Poly)fluoroarenes in Organic Synthesis

Budiman,

Perutz,

Steel

et al. 2024

Chem. Rev.

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The synthesis of organic compounds efficiently via fewer steps but in higher yields is desirable as this reduces energy and reagent use, waste production, and thus environmental impact as well as cost. The reactivity of C−H bonds ortho to fluorine substituents in (poly)fluoroarenes with metal centers is enhanced relative to meta and para positions. Thus, direct C−H functionalization of (poly)fluoroarenes without prefunctionalization is becoming a significant area of research in organic chemistry. Novel and selective methodologies to functionalize (poly)fluorinated arenes by taking advantage of the reactivity of C−H bonds ortho to C−F bonds are continuously being developed. This review summarizes the reasons for the enhanced reactivity and the consequent developments in the synthesis of valuable (poly)fluoroarene-containing organic compounds.

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Section: Introductionmentioning

confidence: 99%