Fluorine-ion-releasing injectable alginate nanocomposite hydrogel for enhanced bioactivity and antibacterial property

Shin, Da Yong; Cheon, Kwang Hee; Song, Eun Ho; Seong, Yun Jeong; Park, Ji Ung; Kim, Hyoun Ee; Jeong, Seol Ha

doi:10.1016/j.ijbiomac.2018.11.108

Cited by 26 publications

(21 citation statements)

References 40 publications

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“…The rheological behaviors of the Alg and Alg-PDRN hydrogels were examined using a rheometer (ARES, Rheometric Scientific, USA) 52 , 53 . First, 1 ml of the hydrogels was placed between 20-mm-diameter parallel plates, and then, frequency sweep tests were performed under a constant strain of 0.5% in the frequency range of 1.0–100 rad/s.…”

Section: Methodsmentioning

confidence: 99%

Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing

Shin

Park

Choi

et al. 2020

Sci Rep

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Patients with diabetes experience delayed wound healing because of the uncontrolled glucose level in their bloodstream, which leads to impaired function of white blood cells, poor circulation, decreased production and repair of new blood vessels. Treatment using polydeoxyribonucleotide (PDRN), which is a DNA extracted from the sperm cells of salmon, has been introduced to accelerate the healing process of diabetic wounds. To accelerate the wound-healing process, sustained delivery of PDRN is critical. In this study, taking advantage of the non-invasive gelation property of alginate, PDRN was loaded inside the hydrogel (Alg-PDRN). The release behavior of PDRN was altered by controlling the crosslinking density of the Alg hydrogel. The amount of PDRN was the greatest inside the hydrogel with the highest crosslinking density because of the decreased diffusion. However, there was an optimal degree of crosslinking for the effective release of PDRN. In vitro studies using human dermal fibroblasts and diabetes mellitus fibroblasts and an in ovo chorioallantoic membrane assay confirmed that the Alg-PDRN hydrogel effectively induced cell proliferation and expression of angiogenic growth factors and promoted new blood vessel formation. Its effectiveness for accelerated diabetic wound healing was also confirmed in an in-vivo animal experiment using a diabetic mouse model.

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Section: Methodsmentioning

confidence: 99%

Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing

Shin

Park

Choi

et al. 2020

Sci Rep

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“…Colonization by potentially pathogenic microbes is a perceived disadvantage of conventional alginate dressings. Antimicrobial variants has been created based upon a combination of alginate and chitosan nanoparticles (Karri et al, 2016), high concentration M based alginate aerogels with an amidated pectin and doxycycline core (De Cicco et al, 2016), and combining alginate and calcium fluorine in a nanocomposite hydrogel, which inhibit bacterial growth and promotion cell proliferation for wound healing (Shin et al, 2019). 3D bioprinting personalized wound dressings holds the potential for the dressings to be printed as biomimics of the defect site, this may be achievable by seeding with skin, fat or muscle cells and/growth factors in order to augment the healing process (Aduba and Yang, 2017) and would also enable the controlled microspatial placement of antimicrobial agents.…”

Section: Wound Healingmentioning

confidence: 99%

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

et al. 2019

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The pursuit of appropriate, biocompatible materials is one of the primary challenges in translational bioprinting. The requirement to refine a biomaterial into a bioink places additional demands on the criteria for candidate biomaterials. The material must enable extrusion as a liquid bioink and yet be capable of maintaining its shape in the post-printing phase to yield viable tissues, organs and biological materials. Plant-derived biomaterials show great promise in harnessing both the natural strength of plant microarchitecture combined with their natural biological roles as supporters of cell growth. The aim of this review article is to outline the most widely used biomaterials derived from land plants and marine algae: nanocellulose, pectin, starch, alginate, agarose, fucoidan, and carrageenan, with an in-depth focus on nanocellulose and alginate. The properties that render these materials as promising bioinks for three dimensional bioprinting is herein discussed alongside their potential in 3D bioprinting for tissue engineering, drug delivery, wound healing, and implantable medical devices.

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“…It has been clearly demonstrated in recent years that zirconium [53], silicon [54] and fluorine [55] incorporated surfaces that can have strong anti-bacterial and anti-infection effects on biofilm development on implant surfaces and improve the biological capability. Fluoride has been known for its bactericidal effect by the disruption in metabolism because of the inhibition of bacterial enzymes and membrane function [55,56]. Recently, silicon and fluoride ions have been reported to enhance the incorporation of newly formed collagen into the bone matrix and increase the rate of seeding of apatite crystals [57,58].…”

Section: Microbiological Studiesmentioning

confidence: 99%

Advanced surface treatment techniques counteract biofilm-associated infections on dental implants

Koopaie

Bordbar‐Khiabani

Kolahdooz

et al. 2020

Mater. Res. Express

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Topography and surface chemistry can significantly affect biofilm formation on dental implants. Recently, the γ-TiAl alloy was considered as the most reliable candidates for the preparation of dental implants because of its excellent mechanical strength, chemical stability and biocompatibility. The emphasis of this study lies in the effects of high-speed milling assisted the minimum quantity of lubrication (HSM-MQL), micro-current wire electrical discharge machining (mWEDM), Er,Cr:YSGG laser and sandblasting/largegrit/acid-etching (SLA) treatments on surface morphology, topography, chemical composition, wettability and biofilm-associated infections on the surface of each group. The surface-treated samples were analyzed using a scanning electron microscope (SEM), SEM surface reconstruction, energy dispersive x-ray spectroscopy (EDS) and water contact angle measuring system. SEM and topography images of mWEDM and laser-treated surfaces showed more irregular surfaces compared to SLA and HSM-MQL surfaces. Results showed that mWEDM and laser-treated surfaces revealed hydrophobic behavior. A significant decrease of biofilm formation was observed on mWEDM treated surface due to the hydrophobicity and existence of the copper element in the recast layer chemical composition. Moreover, EDS confirmed that the zirconium, silicon, and fluorine elements were decorated onto the SLA treated γ-TiAl surface that can have a direct effect on the anti-bacterial activity.

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Fluorine-ion-releasing injectable alginate nanocomposite hydrogel for enhanced bioactivity and antibacterial property

Cited by 26 publications

References 40 publications

Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing

Polydeoxyribonucleotide-delivering therapeutic hydrogel for diabetic wound healing

Plant-Derived Biomaterials: A Review of 3D Bioprinting and Biomedical Applications

Advanced surface treatment techniques counteract biofilm-associated infections on dental implants

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