Fluorine-containing graphene quantum dots with a high singlet oxygen generation applied for photodynamic therapy

Li, Zhenzhen; Wang, Dong; Xu, Mingsheng; Wang, Jingmin; Hu, Xiaolong; Sadat, Anwar; Tedesco, Antônio Cláudio; Morais, P.C.; Hong, Bo

doi:10.1039/c9tb02529d

Cited by 69 publications

(50 citation statements)

References 56 publications

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“…This means they can now be readily applied in various fields including photo/electrocatalysis, [ 4g ] photoelectric conversion, [ 17 ] biological imaging, [ 4b,18 ] disease diagnosis, [ 19 ] and treatment. [ 4d,20 ]…”

Section: Introductionmentioning

confidence: 99%

Carbon‐Based Quantum Dots with Solid‐State Photoluminescent: Mechanism, Implementation, and Application

Wang

et al. 2020

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Carbon‐based quantum dots (CQDs), including spherical carbon dots and graphene quantum dots, are an emerging class of photoluminescent (PL) materials with unique properties. Great progress has been made in the design and fabrication of high‐performance CQDs, however, the challenge of developing solid‐state PL CQDs have aroused great interest among researchers. A clear PL mechanism is the basis for the development of high‐performance solid‐state CQDs for light emission and is also a prerequisite for the realization of multiple practical applications. However, the extremely complex structure of a CQD greatly limits the understanding of the solid‐state PL mechanism of CQDs. So far, a variety of models have been proposed to explain the PL of solid‐state CQDs, but they have not been unified. This review summarizes the current understanding of the solid‐state PL of solid‐state CQDs from the perspective of energy band theory and electronic transitions. In addition, the common strategies for realizing solid‐state PL in CQDs are also summarized. Furthermore, the applications of CQDs in the fields of light‐emitting devices, anti‐counterfeiting, fingerprint detection, etc., are proposed. Finally, a brief outlook is given, highlighting current problems, and directions for development of solid‐state PL of CQDs.

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Section: Introductionmentioning

confidence: 99%

Carbon‐Based Quantum Dots with Solid‐State Photoluminescent: Mechanism, Implementation, and Application

Wang

et al. 2020

Small

148

129

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“…In vitro and in vivo the researches have shown that GQDs can be used as PDT operators, thus offering highly trained treatment and imaging for cancer. This study also ushers in a new age of carbon nanomaterial PDT specialists who surpass conventional technicians in terms of quantum yield, water dispersibility, pH stability, and bioavailability [160].…”

Section: Bio Imagesmentioning

confidence: 97%

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

et al. 2021

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Graphene quantum dots (GQD) is an efficient nanomaterial composed of one or more layers of graphene with unique properties that combine both graphene and carbon dots (CDs). It can be synthesized using carbon-rich materials as precursors, such as graphite, macromolecules polysaccharides, and fullerene. This contribution emphasizes the utilization of GQD-based materials in the fields of sensing, bioimaging, energy storage, and corrosion inhibitors. Inspired by these numerous applications, various synthetic approaches have been developed to design and fabricate GQD, particularly bottom-up and top-down processes. In this context, the prime goal of this review is to emphasize possible eco-friendly and sustainable methodologies that have been successfully employed in the fabrication of GQDs. Furthermore, the fundamental and experimental aspects associated with GQDs such as possible mechanisms, the impact of size, surface alteration, and doping with other elements, together with their technological and industrial applications have been envisaged. Till now, understanding simple photo luminance (PL) operations in GQDs is very critical as well as there are various methods derived from the optical properties of manufactured GQDs can differ. Lack of determining exact size and morphology is highly required without loss of their optical features. Finally, GQDs are promising candidates in the after-mentioned application fields.

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“…The PS molecules absorb the emitted light—i.e., ultraviolet (UV) or visible (VIS)—which promotes them from the ground state to an excited triplet state passing through an intermediate singlet state, resulting in the generation and release of ROS, such as the singlet oxygen ( 1 O 2 ), at the targeted cell [ 190 ]. However, some PS molecules may undergo a fluorescent process in which they fall from the excited state to a lower energy state by releasing a photon [ 69 ]. These fluorescence properties of some PS have been used for real-time medical detection and bio-imaging of various diseases such as cancer, Alzheimer’s, etc.…”

Section: Role Of Gqds In Therapy Developmentmentioning

confidence: 99%

“…These fluorescence properties of some PS have been used for real-time medical detection and bio-imaging of various diseases such as cancer, Alzheimer’s, etc. [ 69 , 108 ]. These multi-functional PSs are known as theranostic agents, as they work for both medical diagnostics and therapy.…”

Section: Role Of Gqds In Therapy Developmentmentioning

confidence: 99%

Graphene Quantum Dots as Flourishing Nanomaterials for Bio-Imaging, Therapy Development, and Micro-Supercapacitors

et al. 2020

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Graphene quantum dots (GQDs) are considerably a new member of the carbon family and shine amongst other members, thanks to their superior electrochemical, optical, and structural properties as well as biocompatibility features that enable us to engage them in various bioengineering purposes. Especially, the quantum confinement and edge effects are giving GQDs their tremendous character, while their heteroatom doping attributes enable us to specifically and meritoriously tune their prospective characteristics for innumerable operations. Considering the substantial role offered by GQDs in the area of biomedicine and nanoscience, through this review paper, we primarily focus on their applications in bio-imaging, micro-supercapacitors, as well as in therapy development. The size-dependent aspects, functionalization, and particular utilization of the GQDs are discussed in detail with respect to their distinct nano-bio-technological applications.

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Fluorine-containing graphene quantum dots with a high singlet oxygen generation applied for photodynamic therapy

Abstract: Compared with graphene quantum dots (GQDs), fluorine-containing GQDs (F-GQDs) present higher 1O2 generation under light irradiation and thus cause obvious toxicity to HepG2 cells. F-GQDs can be used as a photosensitizer for photodynamic therapy.

Cited by 69 publications

References 56 publications

Carbon‐Based Quantum Dots with Solid‐State Photoluminescent: Mechanism, Implementation, and Application

Carbon‐Based Quantum Dots with Solid‐State Photoluminescent: Mechanism, Implementation, and Application

Outstanding Graphene Quantum Dots from Carbon Source for Biomedical and Corrosion Inhibition Applications: A Review

Graphene Quantum Dots as Flourishing Nanomaterials for Bio-Imaging, Therapy Development, and Micro-Supercapacitors

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