Fluorine-19 MRS: General Overview and Anaesthesia

Menon, David

doi:10.1002/9780470034590.emrstm0169

Cited by 2 publications

(3 citation statements)

References 45 publications

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“…Menon et al [39] demonstrated the feasibility of such studies and found halothane signal up to 90 min after the withdrawal of anesthetic. Lockwood et al [31] studied isoflurane kinetics and showed biphasic elimination with decay halftimes of 9.5 and 130 min.…”

Section: Other Drugs: Retention Of Anestheticsmentioning

confidence: 96%

“…McSheehy et al [38] discussed applications of 19 F magnetic resonance spectroscopy (MRS) to oncology. Menon [39] focused on the studies involving fluorinated anesthetic agents. Passe et al [40] reviewed neuropsychiatric applications of NMR, which included a discussion on 19 F NMR applications.…”

Section: Introductionmentioning

confidence: 99%

“…19 F NMR has been used since the eighties for in vivo studies. In the past, various reviewers have discussed diverse applications of in vivo 19 F NMR [21,27,28,[33][34][35][36][37][38][39][40][41]. Thomas [33], Selinsky and Burt [34], Prior et al [35] and London [36] reviewed the contemporary state-of-the-art, covering the entire spectrum of in vivo applications.…”

Section: Introductionmentioning

confidence: 99%

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19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Jian¹,

Kodibagkar²,

Cui³

et al. 2005

CMC

229

185

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The fluorine atom provides an exciting tool for diverse spectroscopic and imaging applications using Magnetic Resonance. The organic chemistry of fluorine is widely established and it can provide a stable moiety for interrogating many aspects of physiology and pharmacology in vivo. Strong NMR signal, minimal background signal and exquisite sensitivity to changes in the microenvironment have been exploited to design and apply diverse reporter molecules. Classes of agents are presented to investigate gene activity, pH, metal ion concentrations (e.g., Ca(2+), Mg(2+), Na(+)), oxygen tension, hypoxia, vascular flow and vascular volume. In addition to interrogating speciality reporter molecules, (19)F NMR may be used to trace the fate of fluorinated drugs, such as chemotherapeutics (e.g., 5-fluorouracil, gemcitabine), anesthetics (e.g., isoflurane, methoxyflurane) and neuroleptics. NMR can provide useful information through multiple parameters, including chemical shift, scalar coupling, chemical exchange and relaxation processes (R1 and R2). Indeed, the large chemical shift range (approximately 300 ppm) can allow multiple agents to be examined, simultaneously, using NMR spectroscopy or chemical shift selective imaging.

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Section: Other Drugs: Retention Of Anestheticsmentioning

confidence: 96%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Jian¹,

Kodibagkar²,

Cui³

et al. 2005

CMC

229

185

View full text Add to dashboard Cite

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Pharmaceutical Design and Development of Perfluorocarbon Nanocolloids for Oxygen Delivery in Regenerative Medicine

Lambert

Gorantla

Janjić

2019

Nanomedicine (Lond.)

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Perfluorocarbons (PFCs) have been investigated as oxygen carriers for several decades in varied biomedical applications. PFCs are chemically and biologically inert, temperature and storage stable, pose low to no infectious risk, can be commercially manufactured, and have well established gas transport properties. In this review, we highlight design and development strategies for their successful application in regenerative medicine, transplantation and organ preservation. Effective tissue preservation strategies are key to improving outcomes of extremity salvage and organ transplantation. Maintaining tissue integrity requires adequate oxygenation to support aerobic metabolism. The use of whole blood for oxygen delivery is fraught with limitations of poor shelf stability, infectious risk, religious exclusions and product shortages. Other agents also face clinical challenges in their implementation. As a solution, we discuss new ways of designing and developing PFC-based artificial oxygen carriers by implementing modern pharmaceutical quality by design and scale up manufacturing methodologies.

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Fluorine-19 MRS: General Overview and Anaesthesia

Cited by 2 publications

References 45 publications

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

19F: A Versatile Reporter for Non-Invasive Physiology and Pharmacology Using Magnetic Resonance

Pharmaceutical Design and Development of Perfluorocarbon Nanocolloids for Oxygen Delivery in Regenerative Medicine

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