Fluorine-19 Magnetic Resonance Imaging and Positron Emission Tomography of Tumor-Associated Macrophages and Tumor Metabolism

Shin, Soo Hyun; Park, Sang Hyun; Kang, Se Hun; Kim, Seung Won; Kim, Min-Sun; Kim, Daehong

doi:10.1155/2017/4896310

Cited by 12 publications

(5 citation statements)

References 34 publications

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“…Using super magnetic iron oxide and perfluorocarbon nanoemulsions, quantitative monitoring of TAM is possible with MRI-based TAM imaging. A study was conducted using MRI-based measurements of TAMs as a prognostic marker and PET to observe tumour behaviour with 18 F -2-fluroro-2-deoxy-D-glucose as a radioactive tracer [ 167 ]. Ultra-small AGulX NPs are made of polysiloxane and are surrounded by gadolinium chelates.…”

Section: Theranosticsmentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

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Nanomaterials, such as nanoparticles, nanorods, nanosphere, nanoshells, and nanostars, are very commonly used in biomedical imaging and cancer therapy. They make excellent drug carriers, imaging contrast agents, photothermal agents, photoacoustic agents, and radiation dose enhancers, among other applications. Recent advances in nanotechnology have led to the use of nanomaterials in many areas of functional imaging, cancer therapy, and synergistic combinational platforms. This review will systematically explore various applications of nanomaterials in biomedical imaging and cancer therapy. The medical imaging modalities include magnetic resonance imaging, computed tomography, positron emission tomography, single photon emission computerized tomography, optical imaging, ultrasound, and photoacoustic imaging. Various cancer therapeutic methods will also be included, including photothermal therapy, photodynamic therapy, chemotherapy, and immunotherapy. This review also covers theranostics, which use the same agent in diagnosis and therapy. This includes recent advances in multimodality imaging, image-guided therapy, and combination therapy. We found that the continuous advances of synthesis and design of novel nanomaterials will enhance the future development of medical imaging and cancer therapy. However, more resources should be available to examine side effects and cell toxicity when using nanomaterials in humans.

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Section: Theranosticsmentioning

confidence: 99%

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

2020

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“…A plethora of studies are underway to evaluate the various properties of PFCs. They are found feasible for applications such as hypothermic total or partial liquid ventilation of the lungs [135][136][137][138][139], in vivo visualization of the effects of antibiotic therapy [140], oligonucleotide therapeutics [141], cell tracking [142], including stem cells [143][144][145], specific detection of organ rejection [146], identifying penumbra in stroke patient [147], quantifying immune cells (tumour-associated macrophages) in the tumour microenvironment [148][149][150], organ preservation [151], quantifying renal vascular damage [152], 19 F-oximetry [153], inflammation imaging of various diseases [154][155][156][157][158][159], gasification-enhanced photoacoustic cavitation [160] etc. There are some excellently written reviews for further reference on PFCs used for oxygen delivery [55,63,73,124,[161][162][163][164], imaging inflammation [48,91,165,166], and cell tracking [65,98,…”

Section: Biomedical Applications Of Pfc Moleculesmentioning

confidence: 99%

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

et al. 2022

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Simultaneously being a non-radiative and non-invasive technique makes magnetic resonance imaging (MRI) one of the highly sought imaging techniques for the early diagnosis and treatment of diseases. Despite more than four decades of research on finding a suitable imaging agent from fluorine for clinical applications, it still lingers as a challenge to get the regulatory approval compared to its hydrogen counterpart. The pertinent hurdle is the simultaneous intrinsic hydrophobicity and lipophobicity of fluorine and its derivatives that make them insoluble in any liquids, strongly limiting their application in areas such as targeted delivery. A blossoming technique to circumvent the unfavorable physicochemical characteristics of perfluorocarbon compounds (PFCs) and guarantee a high local concentration of fluorine in the desired body part is to encapsulate them in nanosystems. In this review, we will be emphasizing different types of nanocarrier systems studied to encapsulate various PFCs and fluorinated compounds, headway to be applied as a contrast agent (CA) in fluorine-19 MRI (19F MRI). We would also scrutinize, especially from studies over the last decade, the different types of PFCs and their specific applications and limitations concerning the nanoparticle (NP) system used to encapsulate them. A critical evaluation for future opportunities would be speculated.

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“…Surface modification of iron oxide NPs with folate has demonstrated to increase the uptake in macrophages via folate receptor-β, which is highly expressed in TAM [92]. Perfluorocarbon nanoemulsions have also been employed for murine breast cancer MRI diagnosis [93]. Pérez-Medina et al have developed an 89 Zr-modified reconstituted HDL (rHDL) nanotracers for TAM PET imaging in a murine model of breast cancer [94].…”

Section: Nps To Target Tam For Cancer Diagnostics and Prognosismentioning

confidence: 99%

Nanoparticles to Target and Treat Macrophages: The Ockham’s Concept?

2021

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Nanoparticles are nanomaterials with three external nanoscale dimensions and an average size ranging from 1 to 1000 nm. Nanoparticles have gained notoriety in technological advances due to their tunable physical, chemical, and biological characteristics. However, the administration of functionalized nanoparticles to living beings is still challenging due to the rapid detection and blood and tissue clearance by the mononuclear phagocytic system. The major exponent of this system is the macrophage. Regardless the nanomaterial composition, macrophages can detect and incorporate foreign bodies by phagocytosis. Therefore, the simplest explanation is that any injected nanoparticle will be probably taken up by macrophages. This explains, in part, the natural accumulation of most nanoparticles in the spleen, lymph nodes, and liver (the main organs of the mononuclear phagocytic system). For this reason, recent investigations are devoted to design nanoparticles for specific macrophage targeting in diseased tissues. The aim of this review is to describe current strategies for the design of nanoparticles to target macrophages and to modulate their immunological function involved in different diseases with special emphasis on chronic inflammation, tissue regeneration, and cancer.

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Fluorine-19 Magnetic Resonance Imaging and Positron Emission Tomography of Tumor-Associated Macrophages and Tumor Metabolism

Cited by 12 publications

References 34 publications

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

Application of Nanomaterials in Biomedical Imaging and Cancer Therapy

Nanotechnology as a Versatile Tool for 19F-MRI Agent’s Formulation: A Glimpse into the Use of Perfluorinated and Fluorinated Compounds in Nanoparticles

Nanoparticles to Target and Treat Macrophages: The Ockham’s Concept?

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