Fluorine-18-Labeled Phospholipid Quantum Dot Micelles for <i>in Vivo</i> Multimodal Imaging from Whole Body to Cellular Scales

Ducongé, Frédéric; Pons, Thomas; Pestourie, Carine; Hérin, Laurence; Thézé, Benoît; Gombert, Karine; Mahler, Benoît; Hinnen, Françoise; Kühnast, Bertrand; Dollé, Frédéric; Dubertret, Benoît; Tavitian, Bertrand

doi:10.1021/bc800179j

Cited by 113 publications

(108 citation statements)

References 23 publications

(45 reference statements)

Supporting

Mentioning

105

Contrasting

Unclassified

Order By: Relevance

“…Researchers were able to study the biodistribution both by whole body PET and by QD fluorescence using in vivo fibered confocal fluorescence microscopy. The authors conclude that this system effectively utilizes two molecular imaging modalities simultaneously: PET for whole body imaging and fluorescence imaging for subcellular localization of tumor cells (Duconge et al 2008). SPECT-QD combinations have also been described (Liang et al 2010).…”

Section: Dual Modality Carriersmentioning

confidence: 92%

Radioisotopes and Nanomedicine

Sheets¹,

Wang²

2011

Radioisotopes - Applications in Bio-Medical Science

View full text Add to dashboard Cite

Section: Dual Modality Carriersmentioning

confidence: 92%

Radioisotopes and Nanomedicine

Sheets¹,

Wang²

2011

Radioisotopes - Applications in Bio-Medical Science

View full text Add to dashboard Cite

“…Another group has investigated phospholipid-QD micelles labeled with 18 F for PET imaging in a murine system. These micelles were found to be well distributed throughout the body with prolonged half-life and slow reticuloendothelial uptake [27]. Altogether, QD micelles, liposomes, and polymer encapsulation formulations can work as PET/MR/optical imaging agents because they show high sensitivity, soft-tissue contrast, and high quantitation capacity.…”

Section: Liposomes and Micellementioning

confidence: 98%

Approaches in the Chemoprevention of Breast Cancer

Kelly¹

2013

J Cancer Sci Ther

View full text Add to dashboard Cite

Nanotechnology in bioscience and therapeutics has advanced tremendously in this decade. Many nanoparticle formulations as well as passive and active targeted agents have been developed and proved effective preclinically in proof-of-concept models of different cancers.Many of these formulations use polymer nanoparticles, liposomes, bubkyballs, fullerenes, carbon nanotubes, dendrimers, isotope tags, and PEG compounds. In effect, nanoparticle formulations have become the norm in chemoprevention. In this paper we review nanoformulations of bioactive compounds that have been tested for their potential mechanistic antiproliferative activity in breast cancer. We also discuss the possibility of enhancing the activity of these compounds using different innovative bioconjugation methods. Citation: Dileep KV, Kelly M, Hardin E, Sadasivan C, Nair HB (2013) Approaches in the Chemoprevention of Breast Cancer. J Cancer Sci Ther 5: 282-288. doi:10.4172/1948-5956.1000217 Volume 5 number of bound reporter metal atoms per vesicle and decrease dosage without compromising signal intensity. Adding specific targeted moieties to the liposomes also could improve the targeting of contrast agents designed for breast cancer imaging. Another research group has recently reported monoclonal antibody to 2C5 (mAb2C5) that can specifically detect tumor cells, leaving the normal cells behind [9]. It is claimed that these liposomes are capable of specifically delivering diagnostic moieties to various tumors with short image acquisition time. Another group has showed PEGylated immunoliposomes labeled with 99 Tc, surface conjugated with F fragment of GAH mAb, could target human gastric cancer in a murine model [10]. Some other studies investigating immunotargeted liposomes for MR imaging enhanced their contrast using gadopentetate dimeglumine (Gd-complex) [11]. MRI signal amplification is also achieved by combining PAP and Gd moietiesin mAb2C5-modified antibodies [12]. Superior in vivo tumor accumulation of mAb2C5 in mouse models of murine Lewis lung carcinoma has been achieved by modified PAP-containing pegylated liposomes, enabling faster detection of the solid tumors [13]. Use of primary and secondary antibodies for increasing the contrast has also been tested. Typically in this inverse imaging technique, patients will receive first antitumor antibody systemically for tumor imaging. This is followed by a second antibody, encapsulated in liposomes directed against the first antibody, which enhances reticuloendothelial (RES) clearance of the first antibody, enabling distinction between normal and tumor tissues [14]. This technology has stability issues with its secondary antibody and needs to be further refined for clinical diagnostic use. Approaches in the Chemoprevention of Breast Cancer Journal ofQuantum dots: Quantum dots (QD) became powerful tools to improve molecular imaging and diagnostics as a result of their unique photophysical properties [15][16][17]. The unique features of QD are resistance to photo bleaching high signal ...

show abstract

“…Duconge et al (2008) successfully synthesized a kind of quantum dot micelles to reduce the nonspecific uptake of RES. This kind of 18 F-QD is quite stable in plasma and be quickly uptaken by varies kinds of organs.…”

Section: Quantum Dots (Qds)mentioning

confidence: 99%

“…This kind of 18 F-QD is quite stable in plasma and be quickly uptaken by varies kinds of organs. 27 Chen et al (2008) synthesized a kind of dual-modality PET/NIRF probe modifying VEGF ( 64 Cu-DOTA-QD705-VEGF). 28 In this study, an aminefunctionalized QD was conjugated with VEGF protein and DOTA chelator for PET/NIRF imaging targeting VEGFR.…”

Section: Quantum Dots (Qds)mentioning

confidence: 99%

Radiolabeled Nanoparticles for In Vivo Tumor PET Imaging

Yang

Bao

Peng

2017

Frontiers in Nanobiomedical Research

View full text Add to dashboard Cite

Positron Emission Tomography (PET) is one of the most sensitive imaging techniques and has been widely used in tumor diagnosis. It can provide a noninvasive and regional estimation of a specific organ with its biochemical processes by introducing a radioactive isotope labeled molecule. Radiolabeled nanoparticles, which have unique characteristics such as large surface area, multifunctionality and long circulation, show great potential in molecular imaging. In this article, we describe the advances in the development of nanoparticle-based tumor PET imaging. Besides the types of radiolabeled nanoparticles (iron-oxide nanoparticles, quantum dots, upconversion nanoparticles (UCNPs), mesoporous silica nanoparticles (MSNs)), the radionuclides, targeting strategies and multimodality imaging are also mentioned.

show abstract

Fluorine-18-Labeled Phospholipid Quantum Dot Micelles for in Vivo Multimodal Imaging from Whole Body to Cellular Scales

Cited by 113 publications

References 23 publications

Radioisotopes and Nanomedicine

Radioisotopes and Nanomedicine

Approaches in the Chemoprevention of Breast Cancer

Radiolabeled Nanoparticles for In Vivo Tumor PET Imaging

Contact Info

Product

Resources

About