Fluorine-18 Fluorodeoxyglucose Imaging Using Dual-Head Coincidence Positron Emission Tomography Without Attenuation Correction in Patients With Head and Neck Cancer

Abstract

FDG CoDe PET is a sensitive and cost-effective method to detect primary tumor and lymph node involvement in primary head and neck cancers. It is also useful in differentiating residual tumor or tumor recurrence from posttherapy changes in patients with head and neck tumors.

F‐18‐fluoro‐deoxy‐glucose positron‐emission tomography scanning in detection of local recurrence after radiotherapy for laryngeal/ pharyngeal cancer

“…[30][31][32] Pai et al 33 have published post-treatment results of dual head PET scanning with FDG for detection of a local recurrence in head and neck cancer, showing a 100% sensitivity and specificity. However, their results are based on a limited group, consisting of 19 patients.…”

Value of 2-[18F]-Fluoro-2-Deoxy-D-Glucose Imaging With Dual-Head Gamma Camera in Coincidence Mode

“…4,11,13 After radiotherapy with or without surgery and chemotherapy, postsurgical distortion, edema, hematoma, and infection may mimic recurrent tumor on CT and MRI (Fig. The presence of recurrent disease is indicative of poor survival, because salvage rates are low.…”

“…The presence of recurrent disease is indicative of poor survival, because salvage rates are low. 4,11,12,14 Histologic confirmation, although usually required for diagnosis, is not ideal, because biopsy can initiate or aggravate radionecrosis, especially in the larynx. Anatomic imaging modalities like CT, MRI, and ultrasound lack the sensitivity to detect recurrence consistently in patients with previously treated head and neck cancers.…”

“…9 Although DHGC systems have certain limitations that diminish image quality and semiquantification compared with dedicated PET, developments such as iterative reconstruction and nonuniform attenuation correction have improved the performance of these systems. [11][12][13] If these results are validated, the dual-head coincidence detection camera, a versatile and widely used device, can be used for modified 18 F-FDG PET studies for this group of patients. [11][12][13] If these results are validated, the dual-head coincidence detection camera, a versatile and widely used device, can be used for modified 18 F-FDG PET studies for this group of patients.…”

Analysis of FDG uptake with hybrid PET using standardised uptake values

“…Recently dual-head gamma cameras capable of coincidence detection (hybrid PET) were introduced as an alternative to dedicated PET systems for FDG imaging in oncological patients [17,18,19,20]. However, only limited data based on phantom studies exist on radioactivity concentration estimations [21] since only some of these camera systems are equipped with devices for transmission scanning to enable non-uniform attenuation correction, a prerequisite for the calculation of SUV.…”