Fluorinated Redox-Responsive Poly(amidoamine) as a Vaccine Delivery System for Antitumor Immunotherapy

Abstract

As a potential method for tumor treatment, tumor vaccine immunization induces a tumor-specific cellular immune response via immunization with tumor antigens. The delivery of exogenous antigen proteins into the cytoplasm of antigen-presenting cells is well known to induce an intensive cellular immune response for tumor treatment. In this work, we fluorinated a redox-responsive hyperbranched poly­(amidoamine) (HPAA) with heptafluorobutyric anhydride to prepare a fluorinated HPAA (HPAA-F7) for use as a vaccine delivery system for antitumor therapy. The immunization results show that HPAA-F7 as a vaccine carrier could effectively promote the intracellular uptake and cytoplasmatic delivery of antigen proteins and induce potent antitumor cellular immunity. The novel vaccine carrier HPAA-F7 could be further developed for antitumor immunotherapy.

Stimuli‐Responsive Nanoparticles for Controlled Drug Delivery in Synergistic Cancer Immunotherapy

“…The biomimetic en‐srNP activated the immune system and enabled the significant elimination of distant and deep cancers, which helped develop advanced synergistic immunotherapy to defeat metastasis tumors. [ 109 ]…”

“…The biomimetic en-srNP activated the immune system and enabled the significant elimination of distant and deep cancers, which helped develop advanced synergistic immunotherapy to defeat metastasis tumors. [109] GSH-mediated en-srNPs have been widely explored and developed in tumor synergistic immunotherapy to kill metastatic tumors and set a long-term tumor memory. [110] These en-srNPs are designed to activate drug release, reverse TME, encapsulate immune drugs, and enhance cascade therapy activity (>100-fold).…”

Development of Effective Tumor Vaccine Strategies Based on Immune Response Cascade Reactions

“…PAMAM-SS-MAN [ 113] PLGA-SS-hgp [ 114] HPAA [ 115] PLH-PEG-SS-OVA [ 116] of melanoma tumors and increased the survival rate of mice to 37.5%. [95] Based on the proton sponge effect, a nanoscale metalorganic framework (nMOF) can achieve a pH-gated release of antigens.…”

“…On the 40th day of in vivo anti‐tumor treatment, 80% of mice injected with HPAA‐F7/OVA survived, which was much higher than in any other test group. [ 115 ] Jiang used poly(l‐histidine)–poly (ethylene glycol) as the backbone to design a cascade of dual‐sensitive micellar vaccines (OLM‐D). When the lysosome of APCs absorbs OLM‐D, the redox response triggers the release of surface‐modified OVA, opening up a proton channel.…”

Targeted therapy of atherosclerosis by pH-sensitive hyaluronic acid nanoparticles co-delivering all-trans retinal and rapamycin

“…Tailoring the composition of NCs to respond to pathological stimuli of the vascular microenvironment may allow in situ cargo release at the targeted site. 25,26 As well documented, atherosclerosis is associated with chronic inflammation, which is characterized by mildly acidic microenvironments, 27 and thereby, targeting this microenvironment via pH-sensitive NCs represents an intriguing approach for atherosclerosis therapy. 25,28 Extensively used for tumor and anti-inflammatory therapies, [29][30][31] pH-sensitive NCs have just recently been started to be exploited for vascular delivery.…”