Fluorinated or brominated meta‐diamides as the new scaffolds for the treatment of rice bacterial leaf blight

Abstract

A global survey of 137 pathogens and pests for five major crops revealed that approximately 17.2%-30% of yield losses occurred yearly in crop-reduced affected areas. The losses were frequently affiliated with emerging and re-emerging pests and diseases (Savary et al., 2019). Crop pathogens have constituted the main challenges in quality and yield losses for agricultural production. Specifically, rice is the main calorie source and stable food for half of the global population worldwide (Bin Rahman & Zhang, 2022). Major rice diseases, including bacterial leaf blight caused by Xanthomonas oryzae pv. oryzae (Xoo), rice blast, and sheath blight, can contribute to rice yield losses ranging from 14.9% to 50% for different locations, seasons, and cultivars (Samaras et al., 2020). Much effort has been devoted to avoiding these crop pathogens, and pesticide use has been one of the major approaches. However, limited by the increasing resistance and cross-resistance of existing pesticides, the creation of novel agrochemicals faces increasing challenges. New molecules with novel modes of action are still crucial for

Design and Enantioselective Synthesis of Chiral Pyranone Fused Indole Derivatives with Antibacterial Activities against Xanthomonas oryzae pv oryzae for Protection of Rice

“…Rice is the world’s most vital crop, serving as the primary calorie source for more than half of the global population. − Rice bacterial leaf blight caused by Xanthomonas oryzae pv oryzae ( Xoo ), a rod-shaped, Gram-negative bacterium, poses a significant threat to rice production − that has led to crop yield decreases ranging from 10% to 50% and enormous economic losses in agriculture every year. − The transmission of rice bacterial leaf blight primarily occurs through lesions on leaf tips, margins, and wounds, giving rise to symptoms such as leaf wilt, necrosis, and other abnormal growth patterns. , Among various control measures, chemical pesticides are pivotal for the management of the rice bacterial leaf blight disease in crop protection, − such as bismerthiazol (BT) and thiodiazole copper (TC), which are widely adopted as bactericides in China to control this disease. Unfortunately, the efficacy of these agrochemicals falls short of expectations.…”

Design, Synthesis, Antibacterial, and Antifungal Evaluation of Phenylthiazole Derivatives Containing a 1,3,4-Thiadiazole Thione Moiety

“…Plant pathogens possess an extremely infectious ability, resulting in a high incidence of plant mortality, which severely affect agricultural production and significantly reduce crop yield and quality [ 1 , 2 , 3 , 4 ]. For instance, R. solanacearum , belongs to a common Gram-negative opportunistic pathogen, can infect an array of crop species including rice, ginger, tomato, potato and tobacco [ 5 , 6 ].…”