Fluorinated N-heterocyclic carbenes rhodium (I) complexes and their activity in hydrosilylation of propargylic alcohols

Synthesis, characterization, crystal structure, α‐glycosidase, and acetylcholinesterase inhibitory properties of 1,3‐disubstituted benzimidazolium salts

“…[34] For example, in the pharmaceutical field, a common strategy for modulating the acidity, conformation, lipophilicity, or even metabolism of a particular drug is by functionalizing a part of the molecule with a fluorinated group. [34][35][36] Also, considering the fluorine as a hydrogen bond acceptor, [37] we can say that the molecules containing the fluorinated NHC ligand have a higher solubility in polar solvents (especially in solvent systems such as water, alcohol, and amine). Additionally, fluorinated NHC ligands and their complexes with different metals have been studied in recent decades.…”

“…[38][39][40][41][42][43][44] Some of the published works in the literature prove that these transition metal complexes containing fluorinated NHC ligand are easy to prepare, require no special handling precautions, and are quite good catalysts in many organic reactions (e.g., hydrosilylation of propargylic alcohols, Mizoroki-Heck arylations, and transfer hydrogenations) giving high yields. [45][46][47][48] These complexes containing fluorinated NHC ligand also possess good biological activities. For example, in a recently published study, synthesis and preliminary cytotoxic activity of a series of fluorinated-NHC complexes have been reported.…”

Coinage metal complexes bearing fluorinated N-Heterocyclic carbene ligands

“…Moreover, fluorinated (NHC)-Ru complexes have been described and employed as efficient catalysts in olefin metathesis [3b-f]. Other ruthenium [6], iridium [6,7], rhodium [7,8] and platinum [9] complexes with fluorinated NHC ligands have also been prepared. In contrast, very few reports of fluorinated NHC-coinage metal complexes are known [10,11].…”

Arene-polyfluoroarene π-π stacking between N-heterocyclic carbene ligands of pentamethylcyclopentadienyl group 9 metal complexes

“…Imidazolium salts are precursors to N-heterocycle carbenes, and so it is reasonable to expect that ─ stacking between the aryl and polyfluoroaryl substituents of NHCs coordinated to metals would also occur. The crystal structures of very few metal complexes of NHCs bearing both aryl-and polyfluoroaryl substitutents have been reported [8][9][10], and none possess intermolecular ─ stacking between the complementary rings, although trans-[PdBr2(κC-C6H5CH2NC3(C4H4)NCH2C6F5)2] does display intramolecular ─ stacking [9]. Complexes of 1-perfluoroarylmethyl-3-benzylimidazol-2-ylidene (I) ( Figure 1) provide a rational area of study because the crystal structures of the precursor imidazolium salts possess ─ stacking [4,6,11,12], and because complexes of 1-polyfluoroaryl-3-arylmethylimidazol-2-ylidene (II)…”