Fluorinated Mn(III)/(II)‐Porphyrin with Redox‐Responsive 1H and 19F Relaxation Properties
Sara M. A. Pinto,
Ana R. R. Ferreira,
Daniela S. S. Teixeira
et al.
Abstract:A new fluorinated manganese porphyrin, (Mn‐TPP‐p‐CF3) is reported capable of providing, based on the Mn(III)/Mn(II) equilibrium, dual 1H relaxivity and 19F NMR response to redox changes. The physical‐chemical characterization of both redox states in DMSO‐d6/H2O evidenced that the 1H relaxometric and 19F NMR properties are appropriate for differential redox MRI detection. The Mn(III)‐F distance (dMn−F=9.7–10 Å), as assessed by DFT calculations, is well tailored to allow for adequate paramagnetic effect of Mn(II… Show more
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