Fluorinated dendritic amphiphiles, their stomatosome aggregates and application in enzyme encapsulation

Guitton-Spassky, Tiffany; Junge, Florian; Singh, Abhishek Kumar; Schade, Boris; Achazi, Katharina; Maglione, Marta; Sigrist, Stephan J.; Rashmi, Rashmi; Haag, Rainer

doi:10.1039/d3nr00493g

Cited by 3 publications

(2 citation statements)

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“…1. For example, techniques that are used to characterise amphiphiles include dynamic light scattering (DLS) 7 and zeta potential, 8 which calculate the hydrodynamic diameter ( d H ) and stability of the self-associated species produced respectively. In addition, diffusion ordered spectroscopy (DOSY) determines the d H of low-order self-associated and individual molecular species through the attainment of individual resonance diffusion coefficients, which are applied to the Stokes–Einstein equation.…”

Section: Introductionmentioning

confidence: 99%

“…In addition, diffusion ordered spectroscopy (DOSY) determines the d H of low-order self-associated and individual molecular species through the attainment of individual resonance diffusion coefficients, which are applied to the Stokes–Einstein equation. 9–11 Furthermore, a range of techniques can be used to study the morphology of the higher-ordered self-associated structures that are formed, such as: atomic force microscopy (AFM); 12 transition electron microscopy (TEM); 13 scanning electron microscopy (SEM); 14 quantitative nuclear magnetic resonance (NMR) spectroscopy; 15 and ultraviolet-visible (UV-Vis) spectroscopy. 16 Defined as chemistry beyond the molecule, supramolecular chemistry is the study of the complex and organised molecular systems that form due to reversible non-covalent interactions, such as hydrogen bonding, in and/or between molecules.…”

Section: Introductionmentioning

confidence: 99%

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Tools to enable the study and translation of supramolecular amphiphiles

Allam,

Balderston,

Chahal

et al. 2023

Chem. Soc. Rev.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Tools to enable the study and translation of supramolecular amphiphiles

Allam,

Balderston,

Chahal

et al. 2023

Chem. Soc. Rev.

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Temperature Control of the Self‐Assembly Process of 4‐Aminoquinoline Amphiphile: Selective Construction of Perforated Vesicles and Nanofibers, and Structural Restoration Capability

Hisamatsu,

Toriyama,

Yamamoto

et al. 2024

Chemistry A European J

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The construction of diverse and distinctive self‐assembled structures in water, based on the control of the self‐assembly processes of artificial small molecules, has received considerable attention in supramolecular chemistry. Cage‐like perforated vesicles are distinctive and interesting self‐assembled structures. However, the development of self‐assembling molecules that can easily form perforated vesicles remains challenging. This paper reports a lower critical solution temperature (LCST) behavior‐triggered self‐assembly property of a 4‐aminoquinoline (4‐AQ)‐based amphiphile with a tetra(ethylene glycol) chain, in HEPES buffer (pH 7.4). This property allows to form perforated vesicles after heating at 80 °C (> LCST). The self‐assembly process of the 4‐AQ amphiphile can be controlled by heating at 80 °C (> LCST) or 60 °C (< LCST). After cooling to room temperature, the selective construction of the perforated vesicles and nanofibers was achieved from the same 4‐AQ amphiphile. Furthermore, the perforated vesicles exhibited slow morphological transformation into intertwined‐like nanofibers but were easily restored by brief heating above the LCST.

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Trends in the Diversification of the Detergentome

Wycisk,

Wagner,

Urner

2023

ChemPlusChem

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Detergents are amphiphilic molecules that serve as enabling steps for today’s world applications. The increasing diversity of the detergentome is key to applications enabled by detergent science. Regardless of the application, the optimal design of detergents is determined empirically, which leads to failed preparations, and raising costs. To facilitate project planning, here we review synthesis strategies that drive the diversification of the detergentome. Synthesis strategies relevant for industrial and academic applications include linear, modular, combinatorial, bio‐based, and metric‐assisted detergent synthesis. Scopes and limitations of individual synthesis strategies in context with industrial product development and academic research are discussed. Furthermore, when designing detergents, the selection of molecular building blocks, i.e., head, linker, tail, is as important as the employed synthesis strategy. To facilitate the design of safe‐to‐use and tailor‐made detergents, we provide an overview of established head, linker, and tail groups and highlight selected scopes and limitations for applications. It becomes apparent that most recent contributions to the increasing chemical diversity of detergent building blocks originate from the development of detergents for membrane protein studies. The overview of synthesis strategies and molecular blocks will bring us closer to the ability to predictably design and synthesize optimal detergents for challenging future applications.

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Fluorinated dendritic amphiphiles, their stomatosome aggregates and application in enzyme encapsulation

Abstract: Enzymes are more selective and efficient than synthetic catalysts but are limited by difficult recycling. This is overcome by immobilisation, namely through encapsulation, with the main drawback of this method...

Cited by 3 publications

References 84 publications

Tools to enable the study and translation of supramolecular amphiphiles

Tools to enable the study and translation of supramolecular amphiphiles

Temperature Control of the Self‐Assembly Process of 4‐Aminoquinoline Amphiphile: Selective Construction of Perforated Vesicles and Nanofibers, and Structural Restoration Capability

Trends in the Diversification of the Detergentome

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