Fluorimetric Properties of 3-Aminoflavone Biomolecule (3-AF). X-ray Crystal Structure of New Polymorph of 3-AF

Abstract

The crystal structure of the new polymorphic form of 3-aminoflavone (3-AF) has been determined by single crystal X-ray diffraction. This report presents results of fluorimetric studies on 3-AF in methanol and aquatic solvents. Based on 3D fluorescence emission spectra, optimal values for excitation (λex) and emission/analytical (λem) wavelength, the analytical concentration range as well as the range of concentration quenching for the studied compound were established. Moreover, the limit of detection (LOD) and the limit of quantification (LOQ) were determined. The results were compared with those obtained using the standard UV-Vis absorption spectrophotometric method. The effect of acidity (pH) and the concentration of halide anions (chlorides, bromides, iodides and fluorides) on fluorescence quenching were analysed.

Heterocycles in Medicinal Chemistry

“…Highly specific articles both present fluorimetric studies on the crystal structure of the new polymorphic form of 3-aminoflavone [3] and the investigations of the dihydrogen bond in the aminoborane complex of a nicergoline intermediate [4]. Sulekova et al published a study evaluating the release of 5-fluorouracil from unmodified and modified mesoporous silica matrices [5].…”

Microwave-assisted Cu(i)-catalyzed one-pot tandem synthesis of pyridoimidazole-fused quinolines as new antimycobacterial agents: DFT and ESI-HRMS study

“…1 Furthermore, using heterocycles as a tool for the modification of physicochemical properties provides an efficient means to optimize the ADME/TOX properties of potential drug candidates. [2][3][4][5] The nitrogen-containing heterocycles in particular are extremely important in medicinal chemistry as they form the basis of several drug molecules. 6 A bioactive nitrogen-containing heterocycle, imidazopyridine, is a hybrid of imidazole and pyridine moieties.…”