Fluorimetric Determination of Sulphaguanidine and Sulphamethoxazole by Host-Guest Complexation in β-Cyclodextrin and Partial Least Squares Calibration

Díez, N. Mora; Peña, Arsenio Muñoz de la; García, M.C.; Bohoyo-Gil, D.; Cañada-Cañada, Florentina

doi:10.1007/s10895-007-0174-4

Cited by 22 publications

(7 citation statements)

References 33 publications

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“…Diez et al . have studied the complex formation between of sulphamethoxazole (SMTX) and sulphaguanidine (SGN) with β‐CD. Based on the result obtained spectrofluorimetric method for determination SMTX and SGN in human urine samples was presented.…”

Section: Analytical Applicationmentioning

confidence: 99%

Spectrofluorometric analytical applications of cyclodextrins

et al. 2013

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Cyclodextrins (CDs) are a family of cyclic oligosaccharides composed of α-(1,4)-linked glucopyranose subunits. The most important feature of CDs is their ability to form inclusion complexes (host-guest complexes) with a very wide range of solid, liquid and gaseous compounds by a molecular complexation. During the last decade, a considerable number of research papers has been focused on the use of CDs to enhance fluorescence intensity of different analytes and to develop CD-induced spectrofluorimetric method. In this review, the various spectrofluorimetric methods based on host-inclusion complex are presented.

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Section: Analytical Applicationmentioning

confidence: 99%

Spectrofluorometric analytical applications of cyclodextrins

et al. 2013

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“…PCA was used for the evaluation of the similarity/dissimilarity of some pesticides, especially fungicides and herbicides, using the effect of a watersoluble β-CD polymer on the apparent pesticide's lipophilicity [63]. Also, partial least square (PLS) modeling was used for the determination of the composition of solutions containing tryptophan methyl ester, phenylalanine, norephedrine, N,N'-bis-(αmethylbenzyl)sulfamide, sulfaguanidine or sulfamethoxazole using the spectral data of the corresponding CD host-guest complexes [64][65][66].…”

Section: Introductionmentioning

confidence: 99%

Discrimination of β-cyclodextrin/hazelnut (Corylus avellana L.) oil/flavonoid glycoside and flavonolignan ternary complexes by Fourier-transform infrared spectroscopy coupled with principal component analysis

Hădărugă¹,

Popescu²,

Gligor³

et al. 2023

Beilstein J. Org. Chem.

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The goal of the study was the discrimination of β-cyclodextrin (β-CD)/hazelnut (Corylus avellana L.) oil/antioxidant ternary complexes through Fourier-transform infrared spectroscopy coupled with principal component analysis (FTIR–PCA). These innovative complexes combine the characteristics of the three components and improve the properties of the resulting material such as the onsite protection against oxidative degradation of hazelnut oil unsaturated fatty acid glycerides. Also, the apparent water solubility and bioaccessibility of the hazelnut oil components and antioxidants can be increased, as well as the controlled release of bioactive compounds (fatty acid glycerides and antioxidant flavonoids, namely hesperidin, naringin, rutin, and silymarin). The appropriate method for obtaining the ternary complexes was kneading the components at various molar ratios (1:1:1 and 3:1:1 for β-CD hydrate:hazelnut oil (average molar mass of 900 g/mol):flavonoid). The recovering yields of the ternary complexes were in the range of 51.5–85.3% and were generally higher for the 3:1:1 samples. The thermal stability was evaluated by thermogravimetry and differential scanning calorimetry. Discrimination of the ternary complexes was easily performed through the FTIR–PCA coupled method, especially based on the stretching vibrations of CO groups in flavonoids and/or CO/CC groups in the ternary complexes at 1014.6 (± 3.8) and 1023.2 (± 1.1) cm−1 along the second PCA component (PC2), respectively. The wavenumbers were more appropriate for discrimination than the corresponding intensities of the specific FTIR bands. On the other hand, ternary complexes were clearly distinguishable from the starting β-CD hydrate along the first component (PC1) by all FTIR band intensities and along PC2 by the wavenumber of the asymmetric stretching vibrations of the CH groups at 2922.9 (± 0.4) cm−1 for ternary complexes and 2924.8 (± 1.4) cm−1 for β-CD hydrate. The first two PCA components explain 70.38% from the variance of the FTIR data (from a total number of 26 variables). Other valuable classifications were obtained for the antioxidant flavonoids, with a high similarity for hesperidin and naringin, according to FTIR–PCA, as well as for ternary complexes depending on molar ratios. The FTIR–PCA coupled technique is a fast, nondestructive and cheap method for the evaluation of quality and similarity/characteristics of these new types of cyclodextrin-based ternary complexes having enhanced properties and stability.

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“…The formation of an inclusion complex greatly affects the physical and chemical properties http of the guest molecules, such as solubility, chemical reactivity and the spectroscopic and electrochemical properties. Most of these effects can be utilized in many fields including pharmaceutical industry [3,4] to improve the solubility, stability and bioavailability of pharmaceuticals. Moreover, these supramolecular structures can be used as carriers of active substances in biological systems and to retard the release of active substances from the pharmaceutical matrix and in various branches of analytical chemistry [5,6].…”

Section: Introductionmentioning

confidence: 99%