Fluoride Exposure and ADHD: A Systematic Review of Epidemiological Studies

Fiore, Gianluca; Veneri, Federica; Lorenzo, Rosaria Di; Generali, Luigi; Filippini, Tommaso

doi:10.3390/medicina59040797

Cited by 8 publications

(1 citation statement)

References 52 publications

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“…This suggests that ozone may be a valid alternative to professionally applied topical fluoride products in very young or uncooperative patients, where accidental ingestion may occur [ 55 ]. It should be considered that early excessive exposure to fluoride has been associated, albeit controversially, with a number of potential adverse health effects and its use may be opposed by some parents or caregivers [ 56 , 57 , 58 , 59 , 60 ].…”

Section: Discussionmentioning

confidence: 99%

Ozone Treatment for the Management of Caries in Primary Dentition: A Systematic Review of Clinical Studies

Veneri,

Filippini,

Consolo

et al. 2024

Dentistry Journal

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Dental caries in children is a frequent and debilitating condition, whose management is often challenging. The aim of this systematic review was to investigate the effectiveness of ozone applications for the treatment of caries in primary dentition. According to PRISMA guidelines, a systematic literature search was performed up to 6 January 2024. Clinical studies using ozone to treat caries of deciduous teeth were considered for inclusion. Out of the 215 records retrieved, seven studies were eventually included in the review, all of which used gaseous ozone. Four studies were judged at high risk of bias, two at low risk, and one of some concerns. The great heterogeneity of designs, outcomes, and protocols made it impossible to conduct a meta-analysis. Despite some limitations, the evidence yielded by the included studies suggests that ozone application, regardless of the protocol applied, is comparable to other interventions in terms of clinical outcomes and anti-bacterial activity, with no reported adverse effects and good patient acceptance. Therefore, ozone application may be a non-invasive approach to treat caries in primary dentition, especially in very young and poorly cooperative patients. Further standardized and rigorous studies are, however, needed to identify the best clinical protocols for this specific field.

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