Fluoride Deposition in the Aged Human Pineal Gland

Lüke, Julia

doi:10.1159/000047443

Cited by 60 publications

(56 citation statements)

References 14 publications

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“…Therefore, F-induced modification of G-proteins could inhibit the release of testosterone, and since testosterone is essential for the initiation of spermatogenesis, this inhibition would eventually lead to low levels of testosterone, thereby impairing spermatogenesis [15,26]. It is reported that fluoride is known to accumulate in the pineal gland [27] and to inhibit the release of melatonin by the pineal gland [28]. Since melatonin has an anti-gonadotropic effect, it is conceivable that fluoride inhibition of melatonin indirectly but significantly increases the level of gonadotropins [29].…”

Section: Discussionmentioning

confidence: 99%

Efficacy of Boerhaavia Diffusa L. On Disruption of Gonadotropins and Testosterone in Fluoride Intoxicated Male Rats

Aggarwal

Khan

2017

Asian J Pharm Clin Res

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Objective: The present study explored the influence of fluoride exposure on gonadotropins and reproductive hormones.Methods: Male Wistar albino rats weighing 100-150 g were administered with 100, 200, and 300 ppm/kg body weight of sodium fluoride daily for 20 and 40 days. The control group was given 1 ml deionized water/kgbw/day for the same period. At the end of the experimental period, half of the animals were sacrificed and blood serum was collected and testis sample was taken concurrently. Remaining half rats were administrated with two doses (250 mg and 500 mg/kg body weight) of leaf extract of Boerhaavia diffusa L. for another 20 days. Serum level of follicle-stimulating hormone (FSH), luteinizing hormone (LH), testosterone, and intratesticular level of testosterone were evaluated.Results: It was found that fluoride intoxication resulted in significant increase in the level of FSH (p<0.01) and LH (p<0.0001) while significant decrease in the serum (p<0.01) and testis (p<0.0001) level of testosterone. A significant (p<0.0001) positive correlation was found between level of serum fluoride and gonadotropins: FSH (20 days, r=0.708 and 40 days, r=0.795) and LH (20 days, r=0.779 and 40 days, r=0.891). However, there was significant (p<0.0001) negative correlation existed between serum fluoride and testosterone levels in serum (20 days, r=−0.780 and 40 days, r=−0.862) as well as testis (20 days, r=−0.915 and 40 days, r=−0.938). Conclusion:It was found that administration of B. diffusa L. alleviated the adverse effects of fluoride on reproductive endocrine functions.

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Section: Discussionmentioning

confidence: 99%

Efficacy of Boerhaavia Diffusa L. On Disruption of Gonadotropins and Testosterone in Fluoride Intoxicated Male Rats

Aggarwal

Khan

2017

Asian J Pharm Clin Res

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“…No entanto, neste estudo, as concentrações de F na pineal dos animais Tratados não diferiram dos animais Controles. Esse resultado não condiz com o encontrado por Luke (2001), o qual observou concentração de F na glândula pineal de humanos, aproximadamente quatro vezes superior aos teores verificados nos ossos.…”

Section: Discussionunclassified

Metabolismo e distribuição do flúor em ovinos jovens tratados cronicamente com fluoreto de sódio

Filappi¹,

Prestes²,

Antes³

et al. 2008

Pesq. Vet. Bras.

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RESUMO.-Este estudo teve por objetivo avaliar o metabolismo do flúor (F) em ovinos. Para tanto, utilizaram-se 12 animais, com cinco meses de idade, os quais receberam como dieta base 3% do peso vivo de feno de alfafa e água ad libitum. Os animais foram divididos e constituí-ram um grupo Controle, que recebeu apenas sal iodado (5g de NaCl/animal + 0,2mg I/kg matéria seca) e, um grupo Tratado, que recebeu sal iodado adicionado de fluoreto de sódio (4,7mg F/kg de peso corporal). Esses sais foram administrados via sonda oro-esofágica, diariamente por um período de 150 dias. Para análise de F, coletaram-se amostras de sangue, urina e fezes e, ao fim do período experimental, após a eutanásia dos animais, coletou-se a glândula pineal e amostras de osso. Também nesta ocasião, coletou-se uma amostra de rim para exame histopatológico. Analisando-se os teores séricos, urinários e ós-seos de F, verificou-se que foram significativamente superiores nos animais Tratados em relação aos Controles. Quanto ao F contido na glândula pineal, não houve diferença significativa entre os grupos. Na análise histológica do rim, não foram observadas alterações. Conclui-se que a administração crônica de flúor induz ao acúmulo desse elemento nos ossos, mesmo havendo um alto teor de cálcio na alimentação e esse acúmulo parece não ser nocivo aos animais. Em ovinos, a capacidade orgânica de acúmulo ósseo e excreção urinária do flúor é diferente de outras espécies animais. The objective of the present study was to evaluate fluorine metabolism in growing lambs. Twelve 5-month-old male lambs maintained on alfalfa hay (3% BW) and nonfluorinated water ad libitum were used. Animals were allocated into Control, receiving 5g NaCl/animal/day + 0.2mg I/kg dry matter) and Treated group, receiving the same treatment plus sodium fluoride (4.7mg F/kg body weight). Mineral treatment was given by gavage, daily for 150 days. Blood, urine and fecal samples were collected during and the end of the experiment. At the end of treatment period animals were euthanized and kidney, pineal and bone samples were collected. Urine F was higher in treated animals throughout the experiment. Bone F levels were also increased in treated animals; pineal F content however, was not different between groups. Kidney histology revealed no differences. It is concluded that chronic F administration induces accumulation of the element in the skeleton. However such fact appears not to be detrimental to animals. Rates of F accumulation in bone and urine excretion obtained in other species can not be used in growing lambs.

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“…An accumulation of fluoride in the pineal gland has been identified in association with aging [145]. Excitotoxicity has been proposed as a central mechanism in fluoride toxicity, in part due to its ability to readily complex with Al to form AlF x complexes [146].…”

Section: Depression Alzheimer's and The Pineal Glandmentioning

confidence: 99%

Aluminum?s Role in CNS-immune System Interactions leading to Neurological Disorders

CA¹

2013

Immunome Res

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Multisystem interactions are well established in neurological disorders, in spite of conventional views that only the central nervous system (CNS) is impacted. We review evidence for mutual interactions between the immune and nervous systems and show how these seem to be implicated in the origin and progression of nervous system disorders. Well-established immune system triggers leading to autoimmune reactions are considered. Of these, aluminum, a known neurotoxicant, may be of particular importance. We have demonstrated elsewhere that aluminum has the potential to induce damage at a range of levels in the CNS leading to neuronal death, circuit malfunction and ultimately, system failure. Aluminum is widely used as an adjuvant in various vaccine formulations and has been implicated in a multisystem disorder termed "autoimmune/inflammatory syndrome induced by adjuvants" (ASIA). The implications of aluminum-induced ASIA in some disorders of the CNS are considered. We propose a unified theory capturing a progression from a local response to a systemic response initiated by disruption of water-based interfaces of exposed cells.

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Fluoride Deposition in the Aged Human Pineal Gland

Cited by 60 publications

References 14 publications

Efficacy of Boerhaavia Diffusa L. On Disruption of Gonadotropins and Testosterone in Fluoride Intoxicated Male Rats

Efficacy of Boerhaavia Diffusa L. On Disruption of Gonadotropins and Testosterone in Fluoride Intoxicated Male Rats

Metabolismo e distribuição do flúor em ovinos jovens tratados cronicamente com fluoreto de sódio

Aluminum?s Role in CNS-immune System Interactions leading to Neurological Disorders

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