Fluoride controlled release tablets for intrabuccal use

Diarra, Mounibé; Pourroy, G.; Boymond, C.; Muster, D.

doi:10.1016/s0142-9612(02)00444-1

Cited by 22 publications

(9 citation statements)

References 21 publications

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“…17 Sustained release fluoride devices, such as buccoadhesive tablets, 18,19 and dental restoratives, including glass ionomer cements, 20 help maintain low but significantly elevated fluoride concentrations in saliva and dental plaque. 15,19,20 However, mucoadhesive tablets are often poorly tolerated by consumers due to the relatively short duration of adhesion to the oral mucosa, their size, and occasionally associated irritancy effects, 21 whilst dental restoratives require professional intervention.…”

Section: Introductionmentioning

confidence: 99%

Chitosan microparticles for the controlled delivery of fluoride

Keegan

Smart

Ingram

et al. 2012

Journal of Dentistry

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Section: Introductionmentioning

confidence: 99%

Chitosan microparticles for the controlled delivery of fluoride

Keegan

Smart

Ingram

et al. 2012

Journal of Dentistry

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“…[2][3] Many devices [4][5] and materials 6 The use of a higher temperature during topical fluoride applications may increase the fluoride recharging and re-release ability of glass ionomers, and a low oral environment temperature should be avoided during topical fluoride application.…”

Section: Introductionmentioning

confidence: 99%

Effects of Temperature on the Fluoride Release and Recharging Ability of Glass Ionomers

Yan

Sidhu²,

Mahmoud³

et al. 2007

Operative Dentistry

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SUMMARYThis study investigated the effects of environmental temperature on the fluoride release and recharging ability of glass ionomers. Five disk specimens (15 mm in diameter and 1 mm thick) were made of each of the following materials: a conventional luting glass ionomer, two high viscosity restorative glass ionomers and a restorative resin-modified glass ionomer. The fluoride release of each material was measured at 4°C, 37°C and 55°C. An additional three groups, which were made of the same materials, were stored in distilled and deionized water for 30 days and recharged in 250 ppm fluoride solution at 4°C, 37°C and 55°C for five minutes. The fluoride rerelease was measured daily from two days prior to two days after the recharging process. At all temperatures, the luting glass ionomers showed the greatest fluoride release and recharging ability, followed by the resin-modified glass ionomer, then the high viscosity glass ionomers. For each material, the fluoride release increased with increasing temperature and all glass ionomers showed greater recharging ability at higher temperatures. An increase in environmental temperature increased both the fluoride release and recharging of the glass ionomers. This may be important in developing regimes for improving the delivery of topical fluoride products.

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“…EUD polymers have been proposed for use in various studies because of their good stability, reproducible release rates of active substance, and mucosal tolerability. [23][24][25] In this context, the objective of this investigation was to develop a suitable mucoadhesive NP formulation with FLZ and to examine its efficacy for the treatment of OC by evaluation of its cytotoxicity and in vitro and in vivo antifungal activity.…”

mentioning

confidence: 99%

Development, characterization, and in vivo assessment of mucoadhesive nanoparticles containing fluconazole for the local treatment of oral candidiasis

Rençber¹,

Karavana²,

Yılmaz³

et al. 2016

IJN

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This study aimed to develop a suitable buccal mucoadhesive nanoparticle (NP) formulation containing fluconazole for the local treatment of oral candidiasis. The suitability of the prepared formulations was assessed by means of particle size (PS), polydispersity index, and zeta potential measurements, morphology analysis, mucoadhesion studies, drug entrapment efficiency (EE), in vitro drug release, and stability studies. Based on the optimum NP formulation, ex vivo drug diffusion and in vitro cytotoxicity studies were performed. Besides, evaluation of the antifungal effect of the optimum formulation was evaluated using agar diffusion method, fungicidal activity-related in vitro release study, and time-dependent fungicidal activity. The effect of the optimum NP formulation on the healing of oral candidiasis was investigated in an animal model, which was employed for the first time in this study. The zeta potential, mucoadhesion, and in vitro drug release studies of various NP formulations revealed that chitosan-coated NP formulation containing EUDRAGIT ® RS 2.5% had superior properties than other formulations. Concerning the stability study of the selected formulation, the formulation was found to be stable for 6 months. During the ex vivo drug diffusion study, no drug was found in receptor phase, and this is an indication of local effect. The in vitro antifungal activity studies showed the in vitro efficacy of the NP against Candida albicans for an extended period. Also, the formulation had no cytotoxic effect at the tested concentration. For the in vivo experiments, infected rabbits were successfully treated with local administration of the optimum NP formulation once a day. This study has shown that the mucoadhesive NP formulation containing fluconazole is a promising candidate with once-a-day application for the local treatment of oral candidiasis.

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Fluoride controlled release tablets for intrabuccal use

Cited by 22 publications

References 21 publications

Chitosan microparticles for the controlled delivery of fluoride

Chitosan microparticles for the controlled delivery of fluoride

Effects of Temperature on the Fluoride Release and Recharging Ability of Glass Ionomers

Development, characterization, and in vivo assessment of mucoadhesive nanoparticles containing fluconazole for the local treatment of oral candidiasis

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